🎉 New in #GENETICS: Functional Genomics & Systems Biology section! Highlighting cutting-edge studies on molecular networks, systems-level insights, and innovative methods. Read more: buff.ly/wWVZdrS%F0%9...

Possible new treatment for Lyme disease: pubmed.ncbi.nlm.nih.gov/40267215/

Possible mechanism for chronic illness following Lyme disease pubmed.ncbi.nlm.nih.gov/40267217/

The 80-year recipe stoking America’s Prosperity: 1) Free-market capital investments in brilliant ideas… 2) enabled by Engineering Innovations… 3) based on Science Research in Universities… 4) funded by Grants from the US Government. It’s time more people understood this.

pubmed.ncbi.nlm.nih.gov/40229440/ How the United States became a science superpower- and how quickly it could crumble

I ran the Pittsburgh marathon Sunday. I was thrilled with how the race and training went. Personal record for me for marathon, and better than my target for today. Thanks to my partner Andrea and my sons and Tiny Dog for their support from training to race day (coach Jack!).

I ran the Nashville Rock ‘n’ Roll half marathon Saturday, benefitting cancer research at St. Jude Children’s Research Hospital. I loved running “with” my son. Personal record for me. Last tune up before next week’s marathon. I love that money is being raised to improve people’s health.

Economists consider impact of changes to funding science and universities www.nytimes.com/2025/03/31/b...

Last call for a postdoc position in single cell analysis/perturb-seq with @nikashakiba.bsky.social at UBC in beautiful Vancouver Canada! ubc.wd10.myworkdayjobs.com/en-US/ubcfac...

Women live longer than men, but how much longer varies widely around the world

Sitting in a journal club-style class right now and after the main presenters present, there are "roles" from others in the group, like the "archeologist" who looks into the citation trail, the "private investigator" who tries to dig into the history, and the "industry practitioner", etc. Cool idea!

oh this is so good

Analysis of NIH found that for every $1.00 of funded research there was $2.56 in economic activity. See the jobs created and economic activity in your state. Read recent research highlights. The “business” of the NIH is improving our health. www.unitedformedicalresearch.org/wp-content/u...

90% of people diagnosed with pancreatic cancer die from the disease. That's why the medical community is excited about the results of a small trial in which nearly half of the pancreatic cancer patients who received an mRNA vaccine for the disease remained relapse-free three years later.

I ran the DC Rock ‘n’ Roll half marathon today, benefitting cancer research at St. Jude Children’s Research Hospital. I was thrilled with how the race and training went. Personal record for me, much better than my previous best half marathon, and better than my target for today.

Nice work assessing the effects of genetic variants in primary human T cells leading to enhanced T cell immunotherapy youtu.be/jO6ybztQnzs?...

Who funds biomedical research? @nature.com www.nature.com/articles/d41...

Congratulations to the new fellows.

I think this short video does a great job explaining why we should all be happy that a small portion of our tax dollars funds basic research youtu.be/GmhD-RWNL6c?...

Exciting seminar on calibrating results from high-throughput functional genomics assays and predictive models for clinical interpretation. youtu.be/TY-C7Dz-Wi4?... @shawnfayer.bsky.social @dougfowler.bsky.social @leastarita.bsky.social #VESS

Overcoming challenges associated with broad sharing of human genomic data Thoughtful perspective on challenges of data sharing followed with recommendations pubmed.ncbi.nlm.nih.gov/39843657/

Exciting seminar on understanding receptor-ligand signaling using mutational scanning. How does a receptor decode ligands to decide whether to signal, or how strongly? youtu.be/hDlJU6HI9Os?...

pubmed.ncbi.nlm.nih.gov/39579740/ I liked this thoughtful review

Hmm…

for heart month, a nice little piece on what we do at Gladstone for the heart gladstone.org/news/matters...

Excellent Info Graphic. Share everywhere!

Exciting talk about measuring, modeling and predicting protein interactions and the effect of variants. youtu.be/hWaRtaP3mno

Aztec mocha Monday!

Good morning! Recovery after yesterday’s 20 mile run. Training is getting real.

There’s a lot of amazingly brilliant scientists and staff about to enter the job market. Hope people take advantage of that and give them a place to land. You won’t regret it

Aztec mocha today

Exciting Variant Effect Seminar Series presentation www.youtube.com/watch?v=mL81...

The Chan Zuckerberg Initiative is awarding BBI researchers $1.5 million over two years to “democratize” access to synthetic DNA. We are envisoning complementary technologies that address shortcomings of current systems for manufacturing DNA. brotmanbaty.org/news/chan-zu... @sudpinglay.bsky.social

Last year I ran 165 times for 1450 miles and biked 22 times for 750 miles. Running included my first 2 marathons. Another year of ramping up my exercise. Grateful to have my health.

pubmed.ncbi.nlm.nih.gov/39572228/ chromatin organization in bacteria

Genome Sciences is looking for a Grants Manager for the Model Organism Genetics labs (which include me!): uwhires.admin.washington.edu/ENG/candidat...

In 1820, 8 in 10 people worldwide lived on less than $1.90* a day, an extremely low poverty line. 200 years later, it had dropped to 1 in 10 people. How do we know how many people were in poverty 200 years ago? Where do these numbers come from?

Five developed countries met the UN’s target for foreign aid in 2023

Cardiovascular disease death rates have fallen rapidly in many countries

A former bandmate sent me this video from a benefit for kids with cancer. Enjoying thinking about helping others, music, and that warm summer day. youtu.be/a-MZPq5V4DM?...

Good morning. Salted caramel mochas today.

2 NIH webinars coming soon: 1) Fellowships and 2) Research grants for institutions that have not been major recipients of NIH Support Register now if interested! nexus.od.nih.gov/all/2025/01/...