📹OUT NOW, our visual article in JoVE Journal! We present a protocol to enable the capture & identification of disease-specific protein-protein interactions from native cells & tissues using chemical probes & mass spectrometry app.jove.com/v/69197/ #Proteomics #SystemsBiology #NetworkBiology #dfPPI

'Epichaperome Remodeling Defines Layer- and Cell-Type-Specific Vulnerability in the Prefrontal Cortex of Alzheimer's Disease Brains' by Sadik Bay at #SfN25. What a great poster session to close out an exciting week of science discussion! #epichaperomics #Alzheimers #omics #neuroscience #therapeutics

'Mapping Epichaperome-Driven Network Dysfunctions in Alzheimer’s Disease Using Dysfunctional Protein-Protein Interactome Analysis' presented by Dr. Anna Rodina at #SfN25! 🤓🧠 Thank you to everyone engaged with our work & Anna for giving a superb presentation! #dfPPI #epichaperome #alzheimers #omics

📸OUT NOW in JoVE Journal: Mapping Dysfunctional Protein-Protein Interactions in Disease. Our method article is available now with video component coming soon! app.jove.com/t/69197 #PPI #networkbiology #cancerbiology #dfPPI #MassSpectrometry #Proteomics

📸OUT NOW in JoVE Journal: Mapping Dysfunctional Protein-Protein Interactions in Disease. Our method article is available now with video component coming soon! app.jove.com/t/69197 #PPI #networkbiology #cancerbiology #dfPPI #MassSpectrometry #Proteomics

🚨Publication alert! The final version of our cover feature article is OUT NOW in @cp-trendsbiochem.bsky.social Read how we connect the #epichaperome with the #chaperone code. #PTMs #HSP90 #PPI #neuroscience #NetworkBiology Check out the review article here: www.sciencedirect.com/science/arti...

Dive deeper into our @cp-trendsbiochem.bsky.social cover article! Read more on @springernature.com Communities: communities.springernature.com/posts/when-m... #Epichaperome #PTMs #NetworkBiology #SystemsBiology #TrendsBiochem #NatureCommunities

📸Check out a few photos from @gabrielachiosis.bsky.social and Tanaya's talks at #CSSI2025 @stresscell.bsky.social l last weekend. #epichaperome #cellularstress #HSP90 #Alzheimers

📢 Our October issue is now online. Access the full issue 👉 www.cell.com/trends/bioch.... 🎨 The cover highlights a Review from @chiosislabmskcc.bsky.social‬ and co on how PTMs reprogram chaperones into epichaperomes.

💡Have you checked out our latest review in @cp-trendsbiochem.bsky.social? Discover how post-translational modifications can convert molecular chaperones into #epichaperomes – stable scaffolds that restructure protein–protein interaction networks in disease #PPI www.sciencedirect.com/science/arti...

Out now in @cp-trendsbiochem.bsky.social: "PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease" from @chiosislabmskcc.bsky.social. Learn more ⬇️

🌟Very excited to share that our article 'PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease' is out online now in @cp-trendsbiochem.bsky.social #PTMs #HSP90 #epichaperome #PPI #neuroscience @mskcancercenter.bsky.social doi.org/10.1016/j.ti...

📝 Online now - the Review "PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease" from @chiosislabmskcc.bsky.social et al. #ProteinProteinInteractions #ProteinNetworks #ChaperoneReprogramming Read it here 👉 authors.elsevier.com/sd/article/S...

Sahil presented earlier this month at #AAIC2025 in Toronto @alzassociation.bsky.social This work was supported by BrightFocus & NIH Aging and aims to advance #precisionmedicine in #neurodegeneration through the development of small molecule probes for #epichaperome imaging in #Alzheimers.

🧵Have you checked out our recent article in Current Opinion in Structural Biology? Follow this thread by Chiosis Lab postdoc Souparna Chakrabarty to learn about the Dysfunctional Protein-Protein Interactome (#dfPPI) - a #chemoproteomic platform www.sciencedirect.com/science/arti... 🧵(1/11)

🧵Follow this thread by Dr. Tanaya Roychowdhury to learn about the intriguing case of #HSP90 - adapted from our recent publication in @natcomms.nature.com (1/8) #cancer #phosphorylation #epichaperome #conformation #cellstress www.nature.com/articles/s41...

🧵Follow this thread by Dr. Tanaya Roychowdhury to learn about the intriguing case of #HSP90 - adapted from our recent publication in @natcomms.nature.com (1/8) #cancer #phosphorylation #epichaperome #conformation #cellstress www.nature.com/articles/s41...

🧵Have you checked out our recent article in Current Opinion in Structural Biology? Follow this thread by Chiosis Lab postdoc Souparna Chakrabarty to learn about the Dysfunctional Protein-Protein Interactome (#dfPPI) - a #chemoproteomic platform www.sciencedirect.com/science/arti... 🧵(1/11)

💫Preprint available now! Our most recent research on #Alzheimers and #epichaperomes is below. Read to find out how #epichaperomes are key mediators of molecular collapse in #AD & what avenues are promising for disease-modifying #therapies🧠 www.researchsquare.com/article/rs-5...

Earlier this month Chiosis Lab postdoc Souparna presented at #cshlnetworks on the #dfPPI platform, a powerful #Chemoproteomics tool to decode stressor-induced #ProteinNetworks dysfunctions in #CancerResearch & #NeurodegenerativeDiseases 🧠👨‍💻 🎊Congrats on your talk Souparna! @cshlmeetings.bsky.social

Accepted manuscript alert! Our review "#Epichaperomes: Redefining #ChaperoneBiology and Therapeutic Strategies in Complex Diseases" is now out in @rscchembio.rsc.org #DrugDiscovery #NetworkMedicine #SystemsBiology #PrecisionTherapeutics pubs.rsc.org/en/content/a...

How do stressors remodel #brain function before symptoms emerge? &network-centric intervention strategies as a promising avenue for disease-modifying #therapy in AD #Alzheimers #epichaperomes #neuroscience #SystemsBiology #networkbiology #drugdiscovery www.researchsquare.com/article/rs-5...

🧠Beyond the Headlines: Ensuring Integrity While Advancing #Alzheimers Research Sensational headlines aren’t the answer. Accountability matters—but so does celebrating the #science driving real solutions. communities.springernature.com/posts/beyond... #Neurodegeneration #journalism #news

💫Preprint available now! Our most recent research on #Alzheimers and #epichaperomes is below. Read to find out how #epichaperomes are key mediators of molecular collapse in #AD & what avenues are promising for disease-modifying #therapies🧠 www.researchsquare.com/article/rs-5...

🧠✨ "How do stressors remodel brain function before symptoms emerge?" Check out researchsquare.com/article/rs-5... exploring how progressive protein network miswiring drives #Alzheimer disease—and how these changes can be reversed. #Neuroscience #Network #SystemsBiology

How do stressors remodel brain function before symptoms emerge? 💫Preprint live now - our most recent research on #Alzheimers & #epichaperomes! Find out how #epichaperomes are key mediators of molecular collapse in #AD & what #therapeutic avenues may be open 🧠 www.researchsquare.com/article/rs-5...