Cynthia Turnbull
@cynturnbull.bsky.social
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Post-doctoral researcher at JCSMR/ANU studying the role of modifier genes in cancer and autoimmunity
reposted by
Cynthia Turnbull
Australian Society for Biochemistry and Molecular Biology - 2025
about 1 month ago
Congratulations to all our
#ASBMB2025
award winners! 🏆 Part of being a society is celebrating the success of our community, so cheers to all of you! 💯💯
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reposted by
Cynthia Turnbull
Eric Topol
3 months ago
Severe, refractory lupus successfully treated with engineered T cells derived from a healthy donor
nature.com/articles/s41...
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Allogeneic CD19-targeting T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial - Nature Medicine
In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and...
https://nature.com/articles/s41591-025-03899-x
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reposted by
Cynthia Turnbull
Nature
3 months ago
Nature research paper: TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function
go.nature.com/3JnVASZ
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TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function - Nature
The transcription factors TCF1 and LEF1 promote self-renewal and regulatory functions in B-1a cells.
https://go.nature.com/3JnVASZ
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Thrilled to see James P Allison present at
#IUIS2025
. His work on CTLA-4 and immune checkpoint blockade fundamentally changed the way we treat cancer, putting immunotherapy on the map, which has saved so many lives. What a wonderful way to end this conference.
3 months ago
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Excellent presentation by
#IUIS2025
rising star Deborah Burnett
@debburnett.bsky.social
touching on the theory of clonal redemption in B cells. Congrats Debbie! 🥳
3 months ago
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Phenomenal work by Sophie Shen
@sophieshen.bsky.social
and Carola Vinuesa
@carovinuesa.bsky.social
on how TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function, presented by Carola at
#IUIS2025
. Read more in the paper released yesterday in Nature:
www.nature.com/articles/s41...
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TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function - Nature
The transcription factors TCF1 and LEF1 promote self-renewal and regulatory functions in B-1a cells.
https://www.nature.com/articles/s41586-025-09421-0
3 months ago
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Had a blast at the Immunology Run as part of
#IUIS2025
! What a fun way to raise funds for travel grants for young researchers. 🏃🏽♀️
3 months ago
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Gabriel Victora
@victora.bsky.social
delighting everyone at
#IUIS2025
with his elegant work on germinal centres, or “Darwinian evolution inside your armpit”. Check out his latest preprint replaying GC evolution on a quantified affinity landscape here:
www.biorxiv.org/content/10.1...
3 months ago
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reposted by
Cynthia Turnbull
3 months ago
In a new preprint we use deep learning on lineage trees to infer the functional form of the relationship between affinity and fitness that controls antibody evolution in germinal centers:
arxiv.org/abs/2508.09871
🧵
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Inference of germinal center evolutionary dynamics via simulation-based deep learning
B cells and the antibodies they produce are vital to health and survival, motivating research on the details of the mutational and evolutionary processes in the germinal centers (GC) from which mature...
https://arxiv.org/abs/2508.09871
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Very excited participate in the 19th International Congress of Immunology,
#IUIS2025
in Vienna. “Where immunologists meet” with over 3000 delegates from 104 countries and 320 oral presentations!
3 months ago
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Explored the Kunsthistorisches Museum Wien, “Museum of Art History” in Vienna. Many beautiful pieces by masters, ceiling art and marvellous architecture by Karl Hasenauer and Gottfried Semper. The building itself is a work of art.
3 months ago
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Honoured to receive the ACT/NSW 7News Young Achiever Award for Academic Achievement (also sponsored by Western Sydney University). It was a bit of a chaotic night flying back from Hawaii! A big thank you to my Dad for meeting me in Sydney and driving me back home!
6 months ago
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reposted by
Cynthia Turnbull
Waggoner Lab
10 months ago
Somatic mutation as an explanation for epigenetic aging
@natureaging.bsky.social
www.nature.com/articles/s43...
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Somatic mutation as an explanation for epigenetic aging - Nature Aging
Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...
https://www.nature.com/articles/s43587-024-00794-x
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