Is Clozapine use hindered?🚧A recent paper sheds light on how to transform care for treatment-resistant schizophrenia Clozapine initiation and maintenance are hampered by misconceptions about side effects and monitoring (e.g., hospitalization/frequent tests) 🩺📋, despite confidence in the guidelines

🔬Molecular Mechanisms of Amisulpride New cell study reveals the complex molecular footprint of the antipsychotic amisulpride. 📊Scientists treated neuroblastoma cells with amisulpride and discovered it changes the levels of key genes and proteins involved in:👇

📢Exciting news #CINP2026 in Glasgow will be a Joint Meeting of the Scandinavian College of Neuropsychopharmacology (SCNP) + the International College of Neuropsychopharmacology! Join us for this unique event which promises to be an outstanding meeting of science & collaboration @ijnp.bsky.social

💊GLP-1 Agonists & Opioid Abuse New translational work examines whether GLP-1 receptor agonists(GLP-1 RAs) could support treatment and/or prevention in people living with opioid use disorder(OUD) 🛡️Early evidence suggests GLP-1 RA administration was linked to reduced risk of opioid overdose in humans

🧠✨ Psychedelics & the Neuroimmune System A new review in Acta Neuropsychiatrica explores how 5-HT2A receptor psychedelics interact with the immune system, and how this interplay may also drive neuronal changes.

🚨 Could AI Chatbots Worsen Mania in Bipolar Disorder? A striking editorial suggests that chatbots may mirror and amplify the elevated mood of users prone to mania, acting like a form of "emotional contagion." 🧠 Check the editorial at: doi.org/10.1017/neu.... #DigitalMentalHealth #AIRegulation

🧩FGF19: Linking Smoke and Mental Health 🚬 Fibroblast growth factor 19 (FGF19) regulates a wide range of biological functions (energy homeostasis, proliferation, survival, and migration) and has an emerging role as an oncology target A recent study on FGF19 in depression and smoking revealed:

🛤️ "The path is known by asking those who have walked it before." — Zulu proverb (South Africa) 🧠 This new study in Acta Neuropsychiatrica examined modifiable & non-modifiable factors linked to mental health changes during COVID-19.

🌍🧠 #WorldBrainDay | July 22 Brain health is vital at every age. From early development to aging, protecting brain function improves lives globally. ➡ 1 in 8 people live with a mental disorder, often affecting cognition, emotion & behavior. #BrainHealthForAll #Neuropsychiatry

A follow-up exome analysis of 270K UK #Biobank participants again found no gene-level associations with affective disorders. Even in severe cases needing specialist referral and in this large sample, rare variant effects are likely too small and spread across many genes.

🧠Is Internet Search a Proxy for Treatment? No, we’re not talking about 🍕restaurants near the Pentagon. But in a similar way, Google Trends mirrors real-world ADHD prescription patterns Researchers found that in Scandinavia (2010–2023) search trends correlate w/ADHD prescriptions

🧠 😞 Late-Life Depression (LLD) LLD is shaped by a complex interplay of biological, psychological, and social factors + distinct clinical and biological features.

EiC @wegener.bsky.social had the pleasure of welcoming the Associate Editor for the Special Content Section, Prof. Gin Malhi (University of Sydney), to the beautiful summer at Aarhus University.

🧠New insights into the mechanism for the motor and #immune deficits of Kabuki syndrome Bapa mice show ↑striatal TH, GFAP, IBA-1—linking #dopaminergic hyperactivity & #neuroinflammation. The strain is a promising model to study motor & immune deficits doi.org/10.1017/neu....

🧠 Handling the Double-Edged Sword of Antipsychotics: Wielding Precision Psychiatry Antipsychotics like aripiprazole & risperidone are widely used—not just for psychosis but also mood & behavioral disorders. Yet, adverse effects may hinder outcomes. 🔄 #Psychiatry #Antipsychotics

🧠 This review just published in Acta Neuropsychiatrica explores how institutionalization in residential care affects children's brain development and mental health, through an electrophysiology perspective. The authors found that:

Can ACT Help Reduce Suicidality? This new systematic review and meta-analysis examined the effectiveness of Acceptance and Commitment Therapy (ACT) on suicidality, including suicidal ideation and attempts. And the authors found that:

Please read this important Editorial from BJPsych, written by 22 Journal Editors of Scientific Psychiatic Journals. doi.org/10.1192/bjp.... @actaneuropsych.bsky.social #MentalHealthResearch #ScienceIntegrity #AcademicFreedom #MentalHealthPolicy #ScientificTruth

🧠🩺 Can #preeclampsia (PE) be addressed by assessing behavioral and metabolic changes? A new study published in Acta Neuropsychiatrica provides evidence that neuropsychiatric symptoms in PE may be linked to immune and metabolic biomarkers. ✅Top 3 #biomarkers identified, with highlights to:

🧠 Mild Behavioral Impairment (MBI) is a challenging sign in dementia, impacting patients, families, and clinical management. Its early manifestation can be associated with faster cognitive decline and poorer prognosis. 🕵️‍♂️ How can we improve risk profiling in patients? 👇

Another one on GLP-1 receptor agonists (GLP-1RA) — Could they be a new avenue for alcohol use disorder (AUD) treatment? 🍷🚫 This recent review explored the potential of GLP-1RAs (like liraglutide/semaglutide) in modulating alcohol-related behaviors in both preclinical and clinical studies.

🧠 GLP-1 Receptor Agonists: A new frontier in mental health treatment? 📚 This systematic review from McIntyre group explores whether GLP-1 receptor agonists (GLP-1 RAs) influence molecular and cellular systems implicated in neurogenesis and...

🧠 Do commonly prescribed SSRIs—sertraline, citalopram, and escitalopram—affect osteoporosis risk? 🦴 This large-scale target trial emulation using real-world data set out to answer that question⬇️

New Research Alert! 🧠🚨 Could neuroinflammation be a key player in ADHD? This study published by Eren-Kocak group explores the impact of perinatal nicotine exposure (PNE) on neurodevelopment. Findings reveal PNE triggers neuroinflammatory signaling in the PFC, leading to:

🧠 Nutraceuticals in Mental Health A recent study published by the Bjørke-Monsen group compared folate and vitamin B12 levels in patients admitted to a psychiatric acute unit (n=981) with controls (primary health care; n=32201) – and the findings are interesting!⬇️

🧬Important Insights into Lewy Body Dementia (LBD)! 🧠The study "Transcriptome-wide Alternative Splicing and Transcript-level Differential Expression Analysis of Post-mortem Lewy Body Dementia Brains" provides significant advances in understanding the molecular mechanisms underlying LBD.

🧠 Recent investigation underscores the potential of non-pharmacological treatments in #psychiatry such as #exosomes, #miRNAs, #stemcell, #mitochondria transfer, #exercise therapy, or #transcranial stimulation. 📌↘️ @altmetric.com @cambridgeup.bsky.social

✨ Innovation on Comprehensive Analysis in Mental Illness - New Advanced Bibliographic Revision Method! 🔍📚 Drs Chen and Ding employed this new comprehensive analysis method capable of analyzing >12,000 papers, far exceeding the capacity of trad tools like VOSviewer @altmetric.com

🧠Does the #immunesystem play a role in accelerated aging in #Schizophrenia (SCZ) and #bipolar disorders (BD)? 🧬 Dr Steen group investigated the link between #telomere length (TL) and plasma levels of 12 immune markers to understand aging in SCZ and BP.

🚨🧠💪 How does the drive for rewards shape health across adolescence and young adulthood? This fascinating longitudinal study investigated the link between reward sensitivity, physical activity, and metabolism. 🧵 #HealthScience #Metabolism #MentalHealth #Fitness #Neuroscience #Reward @altmetric.com

📢 More interesting results on GLP-1 agonist therapy! The recent preclinical data published in Acta Neuropsychiatrica highlights the importance of guiding #GLP-1agonist treatments with robust evidence. 🌟 Key Findings ⬇️ @altmetric.com @cambridgeup.bsky.social

Looking for a home to your paper on #Psychopharmacology or #Immunopsychiatry? Look no further! Final submissions are due February 1st on the Journal submission site. Check the guide for authors on: cambridge.org/core/journal...

NEW research by IoPPN (@cathrynlewis.bsky.social) and @edinburghuni.bsky.social (Andrew McIntosh) researchers have identified new genetic risk factors for #depression across all global populations for the 1st time, in study in Cell Read more: www.kcl.ac.uk/news/global-...

🧠 Azelaic acid (AzA), known for its anti-inflammatory & neuroprotective properties in Parkinson's treatment, now shows promise for cognitive health! ✨ Check this paper just published in Acta Neuropsychiatrica! @altmetric.com @cambridgeup.bsky.social

take the poll! www.nature.com/articles/d41...

💻 Generative AI in mental health is a rapidly moving field! 📚 This study recently published in Acta Neuropsychiatrica aimed to shed light on the use of generative AI in psychiatry and #mentalhealth settings, by systematically reviewing the literature (40 studies examined!).⬇

🌟Neuropsychiatric disorders 🧠 are frequently associated with metabolic comorbidities. The contributions of our most recent Special Issue present a diverse array of studies that illustrate the breadth of Metabolic Neuropsychiatry. Check it out 🧵: www.cambridge.org/core/journal...

New year's eve resolutions can be an opportunity to look ahead, doing more and doing better. What are your resolutions for 2025? (academic and personal?) For us 2025 will be the year of openness 🦋 ↘️

Wishes of a beautiful holiday season!

This new study from Dr. Harkin’s group aimed to investigate mRNA expression of the kynurenine pathway (KP)enzymes in medicated patients with depression, and after ECT therapy. 🧬 Changes in expression of target KP enzymes correlated with changes in mood, w/ treatment response + remission. 📈

🧠 Highlights from Acta Neuropsychiatrica: Top Papers of 2024 Curious about what’s trending in the journal? Discover the most talked-about research of 2024, showcasing what your peers are reading, citing, and discussing. Check what is shaping the future of Psychiatry and stay connected. 🧵

In a recent study, Fukumori et al. explored whether combining psychotherapy with medication is more effective than psychotherapy alone for treating depression. The findings are insightful: 👇 #Psychology #Psychiatry #MentalHealth #DepressionTreatment #CBT #Psychotherapy @altmetric.com

Acta Neuropsychiatrica has an open call for 2 new Special Issues! 🧠Is your paper discussing the Progress in Psychopharmacology or in Immunopsychiatry? Final submissions are due February 1st on the Journal submission site: www.cambridge.org/core/journal...

🧠 Did you know there are still no drugs clearly defined for the treatment of borderline personality disorder? 🧪 In this open-label randomized controlled study, Rothman et al. assessed the efficacy, safety, and tolerability of aripiprazole. ↘️🧵

Pleased to be able to share our meta-analysis exploring placebo and nocebo response in gambling disorder, out now in Acta Neuropsychiatrica. This is the first meta-analysis of placebo response in RCTs for gambling disorder. https://buff.ly/3V8dnk3

🌿Phytotherapy in Psychiatry: Why Psychiatrists Should Care 🧠 💡Did you know the use of ComplementaryMedicine can influence psychiatric outcomes—positively or negatively?

⚡Positive evidence on Transcranial alternating current stimulation (tACS) to neuropsychiatric conditions, as #dyslexia, #anxiety, #depression & #ADHD is beginning to accumulate Lee et al. explored the effects of gamma-frequency tACS applied to F4 and P4 regions. The results?⬇️

There is a high prevalence of neuropsychiatric disorders in myotonic dystrophy types 1 and 2 (DM1 and DM2). In this nicely organized meta-analysis, Dr. Pascual-Morena explored the differences between different psychiatry conditions and their onset. They found that ⬇️:

Acta Neuropsychiatrica has an open call for 2 new Special Issues! 🧠Is your paper discussing the Progress in Psychopharmacology or in Immunopsychiatry? Final submissions are due February 1st on the Journal submission site: cambridge.org/core/journal... Check more details on the SI ⬇️

We are pleased to introduce the 1st special issue of Acta Neuropsychiatrica, which is dedicated to exploring the role of #cannabinoids in #psychiatric research and treatment. cup.org/4f06rgS