A 25-year longitudinal birth cohort study from Estonia reveals how genes, biomarkers, environment, and family shape behavior, mental health, and life trajectories. Findings offer key insights into neurodevelopment, psychiatric risk! @neuropsychochem.bsky.social doi.org/10.1017/neu....

Some papers carry more than scientific weight: they carry legacy. This study honors a deeply respected contributor to Acta Neuropsychiatrica and a leading figure in psychiatry, whose impact continues to shape the field. doi.org/10.1017/neu....

How effective are music-based interventions for mental health in young adults? In this systematic review of clin trials in young adults, found that music therapy, binaural beats & rhythm-based auditory stimulation are associated w/ moderate improvements across multiple domains:

🧠🧬 Autoimmunity as an underexplored contributor to neuropsychiatric symptoms in 22q11.2 deletion syndrome A recent study synthesizes evidence linking autoimmune processes to the neuropsychiatric phenotype observed in 22q11.2 deletion syndrome (22q11DS).

How prevalent are behavioural addictions among adolescents? A newly published study in Acta Neuropsychiatrica suggests insights by examining multiple behavioral addictions simultaneously.

Decision-making in Borderline Personality Disorder (BPD) in Social Context A recent fMRI study publishe in Acta Neuropsychiatrica used a multi-round Ultimatum Game to examine fairness, norm violations, and value processing in individuals with BPD. #fMRI #SocialCognition

As we approach the end of 2025, we would like to send a warm thank you to the entire Acta Neuropsychiatrica community —our dedicated authors, diligent reviewers & committed editorial board members. On behalf of the Acta Neuropsychiatrica and the board of the SCNP.

🧩Exosomes: A New Frontier in Understanding & Treating Autism Spectrum Disorder (ASD) How can they advance ASD research?

🌍 From nomadic origins to modern stress: what can birds teach us about mental health? doi.org/10.1017/neu....

🧠 Could psychedelics help rewire the brain–body disconnect? 💊 + 🧍‍♀️A new pilot study explores this question by investigating psilocybin-assisted therapy in Motor Functional Neurological Disorder (FND), pairing pharmacological and rehabilitative approaches.

🩺 Building Early Pain Literacy Pain-related knowledge can improve quality of life and satisfaction, and the sooner the better ✨In a new study, a pain neuroscience education (PNE) program significantly improved outcomes in adolescents with and without intellectual disabilities.

🍄 What does the evidence say on Psilocybin Therapy in Depression? 📄 A new PRISMA-guided systematic review analyzed 22 clinical studies, including randomized controlled + open-label trials. Populations included treatment-resistant depression and varied dosing and adjunctive protocols

🧩 Rethinking Schizophrenia Emerging evidence suggests schizophrenia has 2 biologically distinct forms: 🔹 Major Neurocognitive Psychosis (MNP) 🔹 Simple Neurocognitive Psychosis (SNP) Both differ in immune and metabolic pathways, especially in how the brain processes tryptophan (TRP)

Navigating the Use of Xanomeline/Trospium (Cobenfy/KarXT) KarXT marks a significant shift as the first muscarinic Our latest paper breaks down the key patient profiles that may benefit most from this novel mechanism of action: doi.org/10.1017/neu....

🎤 Voice over for measuring the physiological stress response. What if the speech could be used as a digital biomarker of stress? Using a validated stress-induction paradigm, researchers analyzed vocal features in relation to salivary cortisol and state anger.

Is Clozapine use hindered?🚧A recent paper sheds light on how to transform care for treatment-resistant schizophrenia Clozapine initiation and maintenance are hampered by misconceptions about side effects and monitoring (e.g., hospitalization/frequent tests) 🩺📋, despite confidence in the guidelines

🔬Molecular Mechanisms of Amisulpride New cell study reveals the complex molecular footprint of the antipsychotic amisulpride. 📊Scientists treated neuroblastoma cells with amisulpride and discovered it changes the levels of key genes and proteins involved in:👇

📢Exciting news #CINP2026 in Glasgow will be a Joint Meeting of the Scandinavian College of Neuropsychopharmacology (SCNP) + the International College of Neuropsychopharmacology! Join us for this unique event which promises to be an outstanding meeting of science & collaboration @ijnp.bsky.social

💊GLP-1 Agonists & Opioid Abuse New translational work examines whether GLP-1 receptor agonists(GLP-1 RAs) could support treatment and/or prevention in people living with opioid use disorder(OUD) 🛡️Early evidence suggests GLP-1 RA administration was linked to reduced risk of opioid overdose in humans

🧠✨ Psychedelics & the Neuroimmune System A new review in Acta Neuropsychiatrica explores how 5-HT2A receptor psychedelics interact with the immune system, and how this interplay may also drive neuronal changes.

🚨 Could AI Chatbots Worsen Mania in Bipolar Disorder? A striking editorial suggests that chatbots may mirror and amplify the elevated mood of users prone to mania, acting like a form of "emotional contagion." 🧠 Check the editorial at: doi.org/10.1017/neu.... #DigitalMentalHealth #AIRegulation

🧩FGF19: Linking Smoke and Mental Health 🚬 Fibroblast growth factor 19 (FGF19) regulates a wide range of biological functions (energy homeostasis, proliferation, survival, and migration) and has an emerging role as an oncology target A recent study on FGF19 in depression and smoking revealed:

🛤️ "The path is known by asking those who have walked it before." — Zulu proverb (South Africa) 🧠 This new study in Acta Neuropsychiatrica examined modifiable & non-modifiable factors linked to mental health changes during COVID-19.

🌍🧠 #WorldBrainDay | July 22 Brain health is vital at every age. From early development to aging, protecting brain function improves lives globally. ➡ 1 in 8 people live with a mental disorder, often affecting cognition, emotion & behavior. #BrainHealthForAll #Neuropsychiatry

A follow-up exome analysis of 270K UK #Biobank participants again found no gene-level associations with affective disorders. Even in severe cases needing specialist referral and in this large sample, rare variant effects are likely too small and spread across many genes.

🧠Is Internet Search a Proxy for Treatment? No, we’re not talking about 🍕restaurants near the Pentagon. But in a similar way, Google Trends mirrors real-world ADHD prescription patterns Researchers found that in Scandinavia (2010–2023) search trends correlate w/ADHD prescriptions

🧠 😞 Late-Life Depression (LLD) LLD is shaped by a complex interplay of biological, psychological, and social factors + distinct clinical and biological features.

EiC @wegener.bsky.social had the pleasure of welcoming the Associate Editor for the Special Content Section, Prof. Gin Malhi (University of Sydney), to the beautiful summer at Aarhus University.

🧠New insights into the mechanism for the motor and #immune deficits of Kabuki syndrome Bapa mice show ↑striatal TH, GFAP, IBA-1—linking #dopaminergic hyperactivity & #neuroinflammation. The strain is a promising model to study motor & immune deficits doi.org/10.1017/neu....

🧠 Handling the Double-Edged Sword of Antipsychotics: Wielding Precision Psychiatry Antipsychotics like aripiprazole & risperidone are widely used—not just for psychosis but also mood & behavioral disorders. Yet, adverse effects may hinder outcomes. 🔄 #Psychiatry #Antipsychotics

🧠 This review just published in Acta Neuropsychiatrica explores how institutionalization in residential care affects children's brain development and mental health, through an electrophysiology perspective. The authors found that:

Can ACT Help Reduce Suicidality? This new systematic review and meta-analysis examined the effectiveness of Acceptance and Commitment Therapy (ACT) on suicidality, including suicidal ideation and attempts. And the authors found that:

Please read this important Editorial from BJPsych, written by 22 Journal Editors of Scientific Psychiatic Journals. doi.org/10.1192/bjp.... @actaneuropsych.bsky.social #MentalHealthResearch #ScienceIntegrity #AcademicFreedom #MentalHealthPolicy #ScientificTruth

🧠🩺 Can #preeclampsia (PE) be addressed by assessing behavioral and metabolic changes? A new study published in Acta Neuropsychiatrica provides evidence that neuropsychiatric symptoms in PE may be linked to immune and metabolic biomarkers. ✅Top 3 #biomarkers identified, with highlights to:

🧠 Mild Behavioral Impairment (MBI) is a challenging sign in dementia, impacting patients, families, and clinical management. Its early manifestation can be associated with faster cognitive decline and poorer prognosis. 🕵️‍♂️ How can we improve risk profiling in patients? 👇

Another one on GLP-1 receptor agonists (GLP-1RA) — Could they be a new avenue for alcohol use disorder (AUD) treatment? 🍷🚫 This recent review explored the potential of GLP-1RAs (like liraglutide/semaglutide) in modulating alcohol-related behaviors in both preclinical and clinical studies.

🧠 GLP-1 Receptor Agonists: A new frontier in mental health treatment? 📚 This systematic review from McIntyre group explores whether GLP-1 receptor agonists (GLP-1 RAs) influence molecular and cellular systems implicated in neurogenesis and...

🧠 Do commonly prescribed SSRIs—sertraline, citalopram, and escitalopram—affect osteoporosis risk? 🦴 This large-scale target trial emulation using real-world data set out to answer that question⬇️

New Research Alert! 🧠🚨 Could neuroinflammation be a key player in ADHD? This study published by Eren-Kocak group explores the impact of perinatal nicotine exposure (PNE) on neurodevelopment. Findings reveal PNE triggers neuroinflammatory signaling in the PFC, leading to:

🧠 Nutraceuticals in Mental Health A recent study published by the Bjørke-Monsen group compared folate and vitamin B12 levels in patients admitted to a psychiatric acute unit (n=981) with controls (primary health care; n=32201) – and the findings are interesting!⬇️

🧬Important Insights into Lewy Body Dementia (LBD)! 🧠The study "Transcriptome-wide Alternative Splicing and Transcript-level Differential Expression Analysis of Post-mortem Lewy Body Dementia Brains" provides significant advances in understanding the molecular mechanisms underlying LBD.

🧠 Recent investigation underscores the potential of non-pharmacological treatments in #psychiatry such as #exosomes, #miRNAs, #stemcell, #mitochondria transfer, #exercise therapy, or #transcranial stimulation. 📌↘️ @altmetric.com @cambridgeup.bsky.social

✨ Innovation on Comprehensive Analysis in Mental Illness - New Advanced Bibliographic Revision Method! 🔍📚 Drs Chen and Ding employed this new comprehensive analysis method capable of analyzing >12,000 papers, far exceeding the capacity of trad tools like VOSviewer @altmetric.com

🧠Does the #immunesystem play a role in accelerated aging in #Schizophrenia (SCZ) and #bipolar disorders (BD)? 🧬 Dr Steen group investigated the link between #telomere length (TL) and plasma levels of 12 immune markers to understand aging in SCZ and BP.

🚨🧠💪 How does the drive for rewards shape health across adolescence and young adulthood? This fascinating longitudinal study investigated the link between reward sensitivity, physical activity, and metabolism. 🧵 #HealthScience #Metabolism #MentalHealth #Fitness #Neuroscience #Reward @altmetric.com

📢 More interesting results on GLP-1 agonist therapy! The recent preclinical data published in Acta Neuropsychiatrica highlights the importance of guiding #GLP-1agonist treatments with robust evidence. 🌟 Key Findings ⬇️ @altmetric.com @cambridgeup.bsky.social

Looking for a home to your paper on #Psychopharmacology or #Immunopsychiatry? Look no further! Final submissions are due February 1st on the Journal submission site. Check the guide for authors on: cambridge.org/core/journal...

NEW research by IoPPN (@cathrynlewis.bsky.social) and @edinburghuni.bsky.social (Andrew McIntosh) researchers have identified new genetic risk factors for #depression across all global populations for the 1st time, in study in Cell Read more: www.kcl.ac.uk/news/global-...

🧠 Azelaic acid (AzA), known for its anti-inflammatory & neuroprotective properties in Parkinson's treatment, now shows promise for cognitive health! ✨ Check this paper just published in Acta Neuropsychiatrica! @altmetric.com @cambridgeup.bsky.social

take the poll! www.nature.com/articles/d41...