Can existing medicines unlock new treatments for mental health? The International Journal of Neuropsychopharmacology IJNP is excited to announce a new Call for Papers for our upcoming special collection: Drug Repurposing in Psychiatry ijnp.net/rp @wegener.bsky.social @liveagodoy.bsky.social

Psychopharmacology is being reshaped by drug repurposing, and it challenges current classification systems #ibogaine We moved from indication-based to mechanism-based classification. But does that fully capture the new psychotropic landscape? A recent IJNP paper proposes a complementary distinction

Can sweet taste preference predict response to naltrexone in alcohol use disorder (AUD)? A recent study published in IJNP evaluated whether the sweet-liking phenotype is associated with response to naltrexone treatment in Taiwanese patients with AUD.

🧠Novel Targets for the Treatment of Schizophrenia: Moving Beyond Dopamine While dopamine blockade remains central to antipsychotic treatment, major unmet needs persist, particularly for negative, cognitive symptoms. Check the collection for more info: academic.oup.com/ijnp/pages/s...

🧠 Neurostimulation is redefining long-term treatment in psychiatry Vagus nerve stimulation (VNS) & sustained benefit in depression 📄 A recent paper published in IJNP reports robust long-term outcomes with VNS in MDD! 📊 Impressive findings:

💊 Preclinical pharmacology with implications for AUD drug development This study reports the preclinical evaluation of MC-100093, a novel compound that reduces voluntary ethanol intake in both male and female rats, supporting its potential as a pharmacological lead for alcohol use disorder.

The Orexin System: Understanding the Modern Insomnia Treatment By pharmacologically targeting dual orexin receptor antagonists (DORAs), this class of agents promotes sleep through a fundamentally different mechanism DORAs ⬇️ the "wake drive" rather than inducing widespread neuronal inhibition

As the year draws to a close, we wish you and your loved ones a very Happy Holiday season and a peaceful, healthy, and productive New Year. We look forward to the continued collaboration of the IJNP community in 2026. On behalf of the IJNP Editorial Management Group

Dopamine's link to positive affect isn't linear—it could be U-shaped🧠 The recently published paper in IJNP shows that an individual's trait positive affectivity critically moderates how dopamine modulation influences state positive affect. In a double-blind design:

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Editor’s Pick of the month! This month’s featured paper delivers important insights for the large group of patients with major depressive disorder who achieve only limited improvement on standard antidepressants.

Opioid and Ketamine in the clinic: key methodological considerations The question of whether ketamine’s antidepressant effects are mediated by glutamatergic plasticity or opioid receptor signalling remains a subject of considerable debate.

🧠 Do dopamine D₂ partial agonists all bind the same way? Maybe not. New evidence challenges the idea that all “third-generation” antipsychotics share a single D₂ receptor binding mode. #Neuropsychopharmacology #Antipsychotics #Dopamine

🧠 Hyperprolactinemia is usually seen as a side effect of antipsychotics — but could it be part of schizophrenia itself? In first-episode, non- to minimally treated patients, there was a clear sex-specific endocrine disturbance.

🧠 Brain–Body in Postoperative Cognitive Dysfunction (POCD) POCD is a common issue in older adults after surgery, causing memory loss + slower thinking But what if the gut has something to do with it? 🦠 IJNP paper highlights how the gut–brain axis shapes recovery after surgery. #GutBrainAxis

Duloxetine for Depression, how it is effectively targeting NET? This is the first study to use PET imaging to track long-term NET occupancy, providing evidence on the SNRI mechanism without the influence of other medications.

In this month’s Editor’s Pick, Hashimoto et al. deliver an insightful meta-analysis comparing personality profiles in schizophrenia & bipolar disorder.

💊Lithium vs. Other Mood Stabilizers: Distinct Metabolic Signatures in #Bipolar Disorder (BP) BD is primarily treated with mood stabilizers (MS): lithium represents the gold standard. Despite its high clinical efficacy, the molecular players in treatment response remain partly unclear👇 #MedEd

New Study Alert: Anhedonia in MDD - Clinical Correlates & Treatment Response🧠 🚨New research published in IJNP confirms anhedonia (MADRS item 8 – inability to feel) as a key marker for severe MDD course.

🚨Call for Symposia – CINP 2026, Glasgow🚨 Be part of shaping the scientific programme at one of Europe’s most vibrant cities!🌍✨ 📅Deadline: 7th October 2025 💡30 symposia slots available – don’t miss this chance! cinp2026.org/submissions/... #cinp #neuropsychopharmacology

📣Join CINP + BJPsych joint journal club to discuss the future of academic psychiatry with Prof Allan Young and experts!

🧠🤖Affective states as clinical signals: AI models for decision-making and symptoms This month’s Editor’s Pick examines the role of affective states in computational psychiatry—a field that uses mathematical and AI-based models to link behavior, brain function, and mental health.

📢Exciting news #CINP2026 in Glasgow will be a Joint Meeting of the Scandinavian College of Neuropsychopharmacology +the International College of Neuropsychopharmacology! Join us for this unique event which promises to be an outstanding meeting of science &collaboration @actaneuropsych.bsky.social

🧠🍷Neurogenesis, Ethanol & biomarker It is known that excessive ethanol disrupts hippocampal structure/function, especially with adolescent onset. But how does neurogenesis plays out in this context?

⚡Beyond the Powerhouse: Mitochondria, Genes, and Depression in a Cross-Species Study 🧠🔋When mitochondrial function falters, the brain struggles to meet energy demands, contributing to the impaired plasticity observed in MDD. #Mitochondria #Depression

We are delighted to announce that the abstracts from CINP-AsCNP 2025 Joint Congress in Melbourne have been published as a Supplement to the International Journal of Neuropsychopharmacology Read the abstracts here: academic.oup.com/ijnp/issue/2...

Is it possible to predict antidepressant response? 📌 Check the Editor’s July Pick in #IJNP This recent study investigated whether brain activity patterns (EEG) could help predict which patients with depression may respond to antidepressants (#vortioxetine or #escitalopram).

🔬 Personality Traits in Schizophrenia vs. Bipolar Disorder Personality traits play pivotal roles in the onset, manifestation, and progression of schizophrenia (SCZ) and bipolar disorder (BD).

🧠 More Than Mood: Anhedonia as a Public Health & Economic Issue How one symptom can ripple through mental health, productivity, and the healthcare system. In a large US study of ~75,000 adults (≥18 years) with depression, higher anhedonia was tied to:

🧠 Over 100 types of RNA modifications exist, but N6-methyladenosine (m6A) is the most prevalent. How are the modifications on neurotransmitters, plasticity and other mechanisms related to #Depression #Autism #Schizophrenia?

🌍World Brain Day | 22 July - Brain Health for All Ages 🧠 As a journal dedicated to advancing neuropsychopharmacology, we join the global neuroscience community in recognizing World Brain Day Understanding brain function in both health and disease is central to improving lives

📢IJNP is pleased to welcome the new EiC, @wegener.bsky.social IJNP continues to publish high-impact original articles, reviews, perspectives, and guidelines in basic and clinical neuropsychopharmacology.

📢 IJNP is pleased to welcome the new Editor-in-Chief, Prof. Gregers Wegener On behalf of the CINP Executive Committee and the new editorial team, we extend our sincere gratitude to Prof Anthony Grace and the editorial board for their outstanding leadership and dedication over the years

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