Bob Coelingh
@bobcoelingh.bsky.social
π€ 262
π₯ 331
π 2
PhD student at Utrecht University Interested in virology and cryo-EM
reposted by
Bob Coelingh
Daniel Hurdiss
about 2 months ago
Had a great time hosting
@proteincapsid.bsky.social
over the past few days. Thanks for the exciting lecture and for sharing your tomography expertise. Until next time!
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reposted by
Bob Coelingh
Daniel Hurdiss
2 months ago
Thrilled, and admittedly relieved, to see this major investment in Dutch
#cryoEM
become reality! π³π±π¬ Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! π¦
www.uu.nl/en/news/33-m...
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33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
https://www.uu.nl/en/news/33-million-euro-investment-for-national-electron-microscope-facility-empower
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reposted by
Bob Coelingh
Daniel Hurdiss
5 months ago
"Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells"
www.biorxiv.org/content/10.1...
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Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells
Cells communicate via extracellular vesicles (EVs) containing functional RNAs, proteins and lipids. Knowledge on the fate of internalized EVs, especially their capacity to fuse with target cell membra...
https://www.biorxiv.org/content/10.1101/2025.07.23.666255v1
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reposted by
Bob Coelingh
Daniel Hurdiss
6 months ago
Interested in our recent norovirus NS3 work? π Join us to dig deeper! I'm recruiting a PhD candidate to investigate NS3's role in viral replication and assembly using
#cryoEM
,
#cryoET
, and other complementary techniques. π
tinyurl.com/4f3t3aae
Please share! π
add a skeleton here at some point
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reposted by
Bob Coelingh
Daniel Hurdiss
7 months ago
Latest preprint from the lab, many years in the making! By combining
#cryoEM
with
#AlphaFold3
modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase. This could have big implications for our understanding of viral replication & assembly (π§΅)
www.biorxiv.org/content/10.1...
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reposted by
Bob Coelingh
Daniel Hurdiss
8 months ago
Think coronavirus spikes have run out of surprises? Think again. Our latest preprint dives into the highly unusual spikes of marine mammal coronaviruses.
www.biorxiv.org/content/10.1...
This
#cryoEM
study was led by
@viralfusion.bsky.social
, with key contributions from an amazing team.
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reposted by
Bob Coelingh
Daniel Hurdiss
10 months ago
Iβm delighted that we could contribute the
#cryoEM
data to this incredible antiviral discovery project from the group of
@neytsjohan.bsky.social
π "A coronavirus assembly inhibitor that targets the viral membrane protein"
www.nature.com/articles/s41...
A huge congrats to everyone involved! π
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reposted by
Bob Coelingh
Utrecht Virology Lab
10 months ago
More picornavirus research from us! π
add a skeleton here at some point
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reposted by
Bob Coelingh
Utrecht Virology Lab
11 months ago
Latest
#virology
research from the lab! π Using genetic approaches and live-cell imaging, we show that the viral 2A protease plays a critical role in subverting antiviral responses and establishing a favorable host environment to expedite enterovirus replication.
www.biorxiv.org/content/10.1...
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The critical role of enterovirus 2A protease in viral translation, replication, and antagonism of host antiviral responses
Enteroviruses dramatically remodel the cellular infrastructure for efficient replication and curtailing host antiviral responses. Proteases 2Apro and 3Cpro have been implicated in these processes base...
https://www.biorxiv.org/content/10.1101/2025.02.20.639337v1
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reposted by
Bob Coelingh
Daniel Hurdiss
about 1 year ago
Iβm looking for a postdoc to join my team under a recently funded ERC Starting Grant. If youβre passionate about structural
#virology
and have experience in
#cryoEM
SPA and/or
#cryoET
, get in touch! Application deadline: January 19th. Please share with your networks π Job link:
tiny.cc/7v33001
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Postdoctoral Researcher in Structural Virology
This project is focused on deciphering the role of virally encoded AAA+ ATPases in the replication cycles of Enteroviruses and Noroviruses.
https://tiny.cc/7v33001
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reposted by
Bob Coelingh
C.A.M(Xander)_de_Haan.bsky.social
about 1 year ago
www.uu.nl/en/organisat...
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Postdoctoral Researcher in Structural Virology
This project is focused on deciphering the role of virally encoded AAA+ ATPases in the replication cycles of Enteroviruses and Noroviruses.
https://www.uu.nl/en/organisation/working-at-utrecht-university/jobs/postdoctoral-researcher-in-structural-virology
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reposted by
Bob Coelingh
cryoEM papers
about 1 year ago
Streamlining segmentation of cryo-electron tomography datasets with Ais
pubmed.ncbi.nlm.nih.gov/39704648/
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reposted by
Bob Coelingh
Thelonevirologist
about 1 year ago
Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists
www.science.org/content/arti...
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Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists
Origins and spread of the vaccine-derived viruses remain mysterious
https://www.science.org/content/article/poliovirus-keeps-popping-european-wastewater-perplexing-and-worrying-scientists
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Amazing science at the Science for Life meeting in Utrecht. The talk by Julia Mahamid was incredible; it most definitely helped me to secure a poster prize too!
add a skeleton here at some point
about 1 year ago
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reposted by
Bob Coelingh
Daniel Hurdiss
almost 2 years ago
Excited to share our first preprint of 2024! π
researchsquare.com/article/rs-3...
This study focuses on PDCoV, an emerging enteric pathogen. We generated anti-spike mAbs & investigated their inhibitory mechanisms using structural & functional studies.
#virology
#cryoEM
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reposted by
Bob Coelingh
Utrecht Virology Lab
about 2 years ago
Our
#TeamTomo
adventure continues! π¬ Here is Bob's first attempt running MemBrain-seg on one of his tomograms π
@bobcoelingh.bsky.social
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