Florian Buchkremer
@swissnephro.bsky.social
📤 758
📥 373
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Nephrologist. Views are my own.
#UrinarySediment
#Hyponatremia
#POCUS
👉 www.swissnephro.org
pinned post!
… and the approximate 5th percentile CKD-EPI 2009 reference values are easy to memorize👇👇👇👇
9 months ago
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Swapnil Hiremath 🍁🇨🇦
11 days ago
Plus cases of Vanishing bile duct syndrome? Eg
www.acpjournals.org/doi/10.7326/...
And
academic.oup.com/rheumatology...
#NephSky
#Vasculitis
#Avacopan
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Avacopan Causing Vanishing Bile Duct Syndrome in an Adult Patient With Microscopic Polyangiitis | Annals of Internal Medicine: Clinical Cases
Microscopic polyangiitis (MPA) is a systemic necrotizing small-vessel vasculitis that may affect multiple organs. Avacopan, an oral complement (C5a) receptor inhibitor, was recently approved and recom...
https://www.acpjournals.org/doi/10.7326/aimcc.2024.0602
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Swapnil Hiremath 🍁🇨🇦
11 days ago
FDA asks Amgen (which bought Chemocentryx) for voluntary withdrawal of Avacopan From January, with fresh Medscape coverage Amgen
www.amgen.com/tavneos-pres...
Medscape
www.medscape.com/s/viewarticl...
- liver concerns - BVAS scoring discrepancy from ADVOCATE
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What’s at Issue in the FDA’s Request to Withdraw Avacopan?
European regulators are also conducting a review of avacopan. The issue appears to involve data from the pivotal ADVOCATE trial and questions of liver safety.
https://www.medscape.com/s/viewarticle/whats-issue-fdas-request-withdraw-avacopan-2026a10005kh
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ZB MED - Informationszentrum Lebenswissenschaften
23 days ago
Danke an @heise.de für die Berichterstattung über das Fundraising für OLSPub und die Einordnung der infrastrukturellen Dimension von Forschungssicherheit. 👉 Artikel:
www.heise.de/news/Di...
👉 Mehr Infos:
www.zbmed.de/forsche...
#OLSPub
#ResearchInfrastructure
#OpenScience
#DigitalSovereignty
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Florian Buchkremer
Arkana Labs
about 1 month ago
Here is today’s
#eyeSCANdy!
Acellular scanning EM showing a glomerulus with fibrocellular crescent (right). Photo courtesy of Dr. Stephen Bonsib.
#renal
#pathology
#kidneypath
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Riko Siempre, RN 🫶🩺【IRIAM US】
23 days ago
Reference:
pmc.ncbi.nlm.nih.gov/articles/PMC...
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The education and medical practice of Dr. James McCune Smith (1813-1865), first black American to hold a medical degree
James McCune Smith (1813-1865)--first black American to obtain a medical degree, prominent abolitionist and suffragist, compassionate physician, prolific writer, and public intellectual--has been relatively neglected by historians of medicine. No ...
https://pmc.ncbi.nlm.nih.gov/articles/PMC2594637/
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To be honest, I think it is much more effective and safer to just learn analyzing venous blood gases directly.
add a skeleton here at some point
23 days ago
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Florian Buchkremer
Arkana Labs
24 days ago
The biopsy shows linear IgG staining along the GBM, and extensive fibrinogen staining within the Bowman space, consistent with crescent formation. These findings are diagnostic of anti-GBM disease.
#renalpath
#kidneypath
#pathology
#renal
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Florian Buchkremer
Arkana Labs
25 days ago
In a patient with AKI and hematuria, what is your diagnosis?
#DiagnoseThis
#nephsky
#pathsky
#renal
#kidneypath
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Arkana Labs
24 days ago
(2/2) ...ANCA-related disease (esp. medullary hemorrhage), trauma, underlying coagulopathy, and, in the transplant setting, both T-cell and antibody-mediated rejection.
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Arkana Labs
24 days ago
The differential diagnosis for interstitial hemorrhage includes hemorrhagic necrosis in the setting of renal artery thrombosis, infection (e.g. herpes simplex virus, adenovirus, hantavirus, Rickettsia),...(1/2)
#TeachingPoints
#kidneypath
#renal
#pathology
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Hilda Bastian
about 1 month ago
Lots to think about in my annual roundup of peer review research: - AI, mostly bad; some suggestions of ways it may help - Evidence on financial rewards for peer review - Influence of editors' biases More on equity & diversity; librarians & systematic reviews
absolutelymaybe.plos.org/2026/02/02/5...
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5 Things We Learned About Journal Peer Review in 2025 - Absolutely Maybe
Back in 2019 I wrote a couple of posts summarizing what we had learned from research about peer review at journals. Since…
https://absolutelymaybe.plos.org/2026/02/02/5-things-we-learned-about-journal-peer-review-in-2025/
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Swapnil Hiremath 🍁🇨🇦
about 1 month ago
telegram-based paper mill
retractionwatch.com/2026/01/26/s...
on
@retractionwatch.com
$165 for first author, $110 for second author, and $55 for the remaining slots welcome to academic publishing!
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Study is stolen, sold, published. Now the victim is accused of plagiarism
The year 2026 did not start off kindly for Vijayalakshmi S, an economics researcher at RV University in Bengaluru, India. She received a rejection letter from a journal noting that a paper of hers …
https://retractionwatch.com/2026/01/26/study-is-stolen-sold-published-now-the-victim-is-accused-of-plagiarism/
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Swapnil Hiremath 🍁🇨🇦
about 1 month ago
The
@nejm.org
publishes this from the Minnesota Physicians Voices
www.nejm.org/doi/full/10....
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#KidneyWk
used to be a highlight of my year and I was really proud to support
@asnkidney.bsky.social
. Its tacit acceptance of Donald Trump and his actions has been a major disappointment for me. So, yes …👇
about 1 month ago
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Swapnil Hiremath 🍁🇨🇦
about 1 month ago
5 reasons to publish with KICR
www.theisn.org/blog/2026/01...
@theisn.org
@arvindcanchi.bsky.social
#NephSky
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Five compelling reasons to submit to Kidney International Case Reports™ - International Society of Nephrology
https://www.theisn.org/blog/2026/01/26/five-compelling-reasons-to-submit-to-kidney-international-case-reports/
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American Journal of Kidney Diseases
about 2 months ago
#NephMadness
2026: Meet the Gamemakers
bit.ly/3Nk10Ap
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Florian Buchkremer
Arkana Labs
2 months ago
What are your differential diagnosis for this ultrastructural finding?
#DiagnoseThis
#nephx
#pathx
#renal
#kidneypath
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Joel Topf
2 months ago
Nice blog post about the various milk options and what they offer kidney patients:
www.medscape.com/viewarticle/...
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Got Milk? It’s a Tricky Question for Renal Patients
Renal diets with limits on protein, potassium, phosphorus, calcium, and sodium make milk choices baffling. Knowing the pros and cons of a variety of milks can help take the guesswork out of breakfast.
https://www.medscape.com/viewarticle/got-milk-its-tricky-question-renal-patients-2025a1000yex?ecd=mkm_ret_251223_mscpmrk_neph_latest-news_etid7978422&uac=125057CJ&impID=7978422
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Florian Buchkremer
Swapnil Hiremath 🍁🇨🇦
3 months ago
Food for thought Science populism, EBM and influencers
absolutelymaybe.plos.org/2025/12/19/s...
from
@hildabast.bsky.social
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Science Populism, Medicine Style - Absolutely Maybe
I hadn’t been aware of the term science populism until a video about it did the rounds recently. It was a light-bulb…
https://absolutelymaybe.plos.org/2025/12/19/science-populism-medicine-style/
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Florian Buchkremer
Kidney Precision Medicine Project
3 months ago
#KPMP
is ending 2025 on a high note with our Q4 2025 Kidney Tissue Atlas Release dropping today 🥳🎉 What are you waiting for? Go check out the explorer, repository AND spatial viewer release highlights!
atlas.kpmp.org
#Kidney
#Atlas
#Nephrology
#PrecisionMedicine
#OpenAccess
#Data
#PublicData
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Florian Buchkremer
Kidney Precision Medicine Project
9 months ago
Explore the KPMP Kidney Tissue Atlas today 🔍 Search markers 🧬Download raw gene data 🗺️Explore spatial data Openly accessible and designed to support discovery 🔗
atlas.kpmp.org
#KPMP
#KidneyResearch
#OpenScience
#KidneyTissueAtlas
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Explorer
https://atlas.kpmp.org/
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Florian Buchkremer
3 months ago
#Alport Syndrome is a Partial #Tubulointerstitial Disease of the #Kidney #VisualAbstract by @Husamjz
https://www.kireports.org/article/S2468-0249(25)00704-1/fulltext
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Thomas Stehlé
4 months ago
GFR Measured With Computerized Tomography Urography in Healthy Individuals and Patients With CKD - American Journal of Kidney Diseases
www.ajkd.org/article/S027...
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GFR Measured With Computerized Tomography Urography in Healthy Individuals and Patients With CKD
Opportunistic CT-based screening is the practice of exploiting incidental imaging data for prevention, risk profiling, or presymptomatic detection of relevant disease unrelated to the purpose for whic...
https://www.ajkd.org/article/S0272-6386%2825%2901143-6/fulltext
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Michelle Rheault, MD
4 months ago
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself) Variants in type IV collagen cause a wide spectrum of disease.
#KidneyWk
🧵
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Swapnil Hiremath 🍁🇨🇦
8 months ago
Nephrologists deported Grants defunded NIDDK folded into National Institute of body parts AHRQ demolished Now this… When are our organizations going to speak up?
#NephSky
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Florian Buchkremer
Swapnil Hiremath 🍁🇨🇦
9 months ago
Hilarious (and sobering) essay on the use of AI in medical research & manuscript writing Read the whole thing! John Daugirdas has been on the cutting edge of tech in meded before
#MedEd
was thing
onlinelibrary.wiley.com/doi/10.1111/...
#MedSky
#NephSky
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Use of Artificial Intelligence in Scientific Writing. The Danger of Trying Too Hard to Please
The author describes his experience using several artificial intelligence programs to assist in the process of editing or preparing manuscripts for publication. While the programs were very useful to...
https://onlinelibrary.wiley.com/doi/10.1111/hdi.13270?af=R
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josh farkas 💊
9 months ago
I am BEGGING major journals to stop platforming the current administration's politicization of the FDA, CDC, vaccines, etc This sort of evidence-lite, glitzy puff piece seems appropriate for a newspaper OpEd, not a medical journal. Platforming it in a major journal gives it the veneer of validity.
add a skeleton here at some point
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Michael Walsh
9 months ago
It's been a long journey but today we can share the methods and rationale for the
#ACHIEVEtrial
(Spiro vs placebo for patients with kidney failure receiving maintenance dialysis) and tomorrow we share the results at
#era25
journals.sagepub.com/doi/10.1177/...
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The Aldosterone Blockade for Health Improvement Evaluation in End-Stage Renal Disease (ACHIEVE) Trial: Rationale and Clinical Research Protocol - Michael Walsh, David Collister, Martin Gallagher, Patr...
Background: The mineralocorticoid aldosterone may contribute to the risk of cardiovascular morbidity and mortality in patients receiving maintenance dialysis. W...
https://journals.sagepub.com/doi/10.1177/20543581251348187
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Florian Buchkremer
UKidney
9 months ago
Update to our supersaturation and kidney stone risk assessment tool: We have added calcium to citrate ratios to the result section providing even greater risk assessment tools to the kit. Thanks very much to Vladimir Belostotsky for the idea!
ukidney.com/calculators/...
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Stephen P Juraschek, MD, PhD, FAHA, AHSCP-CHS
9 months ago
This systematic review shows blood pressure reduction from sodium reduction in the context of antihypertensive medication use. Blood Pressure–Lowering Medications, Sodium Reduction, and Blood Pressure | Hypertension
www.ahajournals.org/doi/10.1161/...
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Blood Pressure–Lowering Medications, Sodium Reduction, and Blood Pressure | Hypertension
BACKGROUND: Both blood pressure–lowering medication and sodium reduction are effective in hypertension control, but whether the effect of sodium reduction differ across blood pressure–lowering medicat...
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.124.23382
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This is such a great resource:
www.kidney-international.org/article/S008...
#nephrology
#eGFR
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Age- and sex-specific reference values of estimated glomerular filtration rate for European adults
Kidney function, often assessed by estimated glomerular filtration rate (eGFR), declines naturally with age. However, there is a lack of eGFR reference values to describe normal and abnormal values fo...
https://www.kidney-international.org/article/S0085-2538(25)00252-2/fulltext
9 months ago
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Rafeeque Mavoor
10 months ago
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!
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Hilda Bastian
10 months ago
This is so exciting! The German National Library of Medicine
@zbmed.bsky.social
just had its first open meeting on the plan for an open & independent PubMed safety net. Here's my write-up
@plos.org
on the meeting & how institutions & others can help
absolutelymaybe.plos.org/2025/05/14/g...
#MedLibs
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Germany's Plan for an Open and Independent PubMed Safety Net - Absolutely Maybe
A few months ago, I wrote about reasons to be concerned about the reliability of PubMed under the new regime at the…
https://absolutelymaybe.plos.org/2025/05/14/germanys-plan-for-an-open-and-independent-pubmed-safety-net/
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JAMA
10 months ago
Amiloride was noninferior to spironolactone in lowering home systolic blood pressure at 12 weeks.
https://ja.ma/42XMGD9
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Jay R. Seltzer, MD
10 months ago
RBC cast - brightfield with SM stain - from new case of MPA -
#UrineMicroscopy
#UrinarySediment
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Sophie Monnerat
10 months ago
Thrilled to unveil the first-in-human use of
#apelin
in
#hyponatremia
at
#ECE2025
in Copenhagen. Endless gratitude to
@christ-crain.bsky.social
for championing bold research paths, and to
@julierefardt.bsky.social
and
@fichapman.bsky.social
, whose groundwork paved the way for this endeavor
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This is absolutely amazing! 👏👏👏👏👏👏👏👏👏👏👏
add a skeleton here at some point
10 months ago
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Florian Buchkremer
UKidney
10 months ago
🧵 Introducing the EQUIL2 Urinary Supersaturation Calculator A powerful web-based tool for nephrologists and researchers to assess kidney stone risk with ease. Based on the validated EQUIL2 algorithm from peer-reviewed scientific literature.
ukidney.com/calculators/...
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EQUIL2 - Urinary Supersaturation Calculator
Calculate urinary supersaturation based on EQUIL2 methodology.
https://ukidney.com/calculators/urinary-supersaturation-and-kidney-stone-risk-tool
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Florian Buchkremer
Katie Wiskar
about 1 year ago
A quick
#VEXUS
thread 🧵- 3 reasons why the portal vein is the most useful single venous doppler waveform 🥇 (if you're only going to do ONE site to look for venous congestion, this is probably the most useful one!)
#emimcc
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Cristina Popa
about 1 year ago
8/Simultaneous publication
#ISNWCN
www.nejm.org/doi/full/10....
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Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis | NEJM
Obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, provided significantly better renal responses than placebo in a phase 2 trial involving patients with lupus nephritis receiving stan...
https://www.nejm.org/doi/full/10.1056/NEJMoa2410965?query=RP
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Cristina Popa
about 1 year ago
Another
@nejm.org
simultaneous publication during
#ISNWCN
, about xenotransplantation Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease
www.nejm.org/doi/full/10....
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Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease | NEJM
Xenotransplantation offers a potential solution to the organ shortage crisis. A 62-year-old hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access...
https://www.nejm.org/doi/full/10.1056/NEJMoa2412747?query=RP&cid=NEJM%20Recently%20Published,%20February%207,%202025%20DM2385540_NEJM_Non_Subscriber&bid=-1502799307
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Florian Buchkremer
StockTitan
about 1 year ago
#UTHR
United Therapeutics Corporation Announces FDA Clearance of its Investigational New Drug Application for the UKidney Xenotransplantation Clinical Trial
https://www.stocktitan.net/news/UTHR/united-therapeutics-corporation-announces-fda-clearance-of-its-i9jdr5owbet7.html
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Revolutionary Pig-to-Human Kidney Transplant Trial Gets Historic FDA Green Light
United Therapeutics advances xenotransplantation with FDA clearance for UKidney™ human trials, offering hope to 557,000+ dialysis patients. First transplants planned for 2025.
https://www.stocktitan.net/news/UTHR/united-therapeutics-corporation-announces-fda-clearance-of-its-i9jdr5owbet7.html
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Florian Buchkremer
Auschwitz Memorial
about 1 year ago
Auschwitz was at the end of a long process. It did not start from gas chambers. This hatred was gradually developed by humans. From ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder. Auschwitz took time.
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Florian Buchkremer
about 1 year ago
This is interesting Aerococcus sanquinicola and Aerococcus urinae in the urine metabolizing creatinine resulting in false low readings with implications for UPCR, UACR and 24 hour urine creatinine collections
www.kireports.org/article/S246...
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A Patient With Unmeasurable Urine Creatinine
A 74-year-old female presented with proteinuria at the nephrology department. Her medical history noted multiple cerebrovascular accidents. Her medication included a daily dosage of clopidogrel 75 mg,...
https://www.kireports.org/article/S2468-0249(24)03483-1/fulltext
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Florian Buchkremer
Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
about 1 year ago
This is me : this is how I scan electronic health records when I try to find the cause of a kidney issue or sort out a complicated medical history. I have refrained from using the phrase "binary search" with my trainees as many will tune out because "computers," but perhaps I should start?
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Florian Buchkremer
Brian Rifkin
about 1 year ago
Doing a fistulagram and the wire goes through a 99% blocked stenosis on the first try!
@asdinnews.bsky.social
add a skeleton here at some point
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Florian Buchkremer
about 1 year ago
SGLT2 Inhibitor #SGLT2i in #Diabetic and #NonDiabetic Renal #Transplant Recipients #VisualAbstract by @DrPSVali
www.kireports.org/ar...
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Florian Buchkremer
Tony Breu
about 4 years ago
1/17 [Why] is furosemide susceptible to malabsorption from "gut edema"? When a patient with heart failure is hospitalized with congestion I often hear "let's use IV furosemide; they're probably not absorbing the PO." It's a comment unique to furosemide. But is it accurate?
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Daniel Fuster
about 1 year ago
Went up slightly from 30 to 35 mmol/d.
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