1/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵 🔗 www.nature.com/articles/s41... #CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics

🌟 The new Academic Women Association (AWA) event is approaching! Workshop Title: Intentional Careers How To Figure Out ‘What’s Next?’ Speaker: Hannah Roberts Date: 2nd March 2026 Time: 12:30 pm Location: LMS Building 7th Floor Seminar Room, Hammersmith Campus Registration is required👇

I’m very pleased to share our work looking at what controls condensin II cell-cycle dependant activity; a great collaboration with @eugenekimlab.bsky.social, @damlatetiker.bsky.social, Kyle Muir and Kumiko Samejima www.biorxiv.org/content/10.6...

📣 We’re hiring 6 new Team Science postdocs! Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone. Find out more and download our brochure below

And the story is published now!🍾 www.nature.com/articles/s41... Open access link: rdcu.be/exnOc Many years in the making, great collaboration with @archaellum.bsky.social & @tunglejic.bsky.social Thanks @ukri.org BBSRC & @leverhulme.ac.uk for funding, reviewers & editor!! 🙏 #microsky #archaeasky

Working with @globalbioimaging.bsky.social, we're very proud to launch our new #AcknowledgementGuidelines poster, helping #ImagingScientists get the credit they deserve for their research contributions! #CreditWhereItsDue @bioimaginguk.bsky.social Read more: rms.org.uk/resource/rms...

💥Our next AWA event is all about networking, mentorship and how to do it in a way that is right for you.😌 Sign up and come along. Everyone from Imperial/ MRC welcome! Limited spaces available, drinks and snacks included 🥂🧀

There's still time to apply for an Emerging Innovators Fellowship for scientists of Black heritage! If you’re ready to take the next step in your career and make an impact in the world of biomedical research, we encourage you to apply. Applications close 11 May 2025. Find out more 👇

#OPENACCESS: FAIR data for optical tweezers experiments. Matthew T.J. Halma, Sowmiyaa Kumar, Jan van Eck, Sanne Abeln, Alexander Gates, and Gijs J.L. Wuite.

How do SMC complexes capture DNA? 🧪 Led by Frank Bürmann, Jan Löwe’s & Mark Dillingham’s groups have identified the directional loading mechanism the bacterial SMC complex MukBEF uses to capture & ingest DNA, & found a phage inhibitor to this pathway. Read more: tinyurl.com/4s8nrrkk #LMBResearch

Yet another preprint from the lab—this one is personal. During my PhD, I ended up working on the cohesin SMC hinge, showing its role in sister chromatid cohesion and proposing it as a DNA entry gate in the SMC ring. But the details have remained mysterious and controversial.