Can one test replace many? A JAMA Pediatrics study by @childrensmercy.org evaluated long-read HiFi sequencing as a first-line approach for pediatric rare disease research, with potential to improve solves, reduce turnaround time, and bypass multiple sequential testing. Read more: bit.ly/3VtHjHh

🚨 Last call! This week, join PAG’s free webinar to see how long-read low-pass sequencing and pangenomes are reshaping #genomics. From structural variation to trait discovery, explore scalable insights across species. Sponsored by #PacBio. Register: bit.ly/4mbCkFU

The 2025 Long-Read Low Pass SMRT Grant for plant + animal sciences is now open! 🌱🐾 Apply to win free PacBio HiFi sequencing for your conservation or agricultural research. Submit your 100-word proposal today: bit.ly/3IgrReu #PacBio #SMRTGrant #HiFisequencing

Ready to celebrate #ASHG25? 🎉 Join us at the PacBio Block Party on October 15 in Boston to network with fellow scientists, connect with the genomics community, and honor 25 years of discoveries and innovation. RSVP now: bit.ly/46xnUeI#ASHG25 #PacBioBlockParty

New Editor's Choice article: "Island biogeography and competition drive rapid venom complexity evolution across rattlesnakes" by Hirst et al. doi.org/10.1093/evol... @hirsticane.bsky.social @RamsesRosales11.bsky.social @marcabeer.bsky.social @jason-strickland.bsky.social @reptilerhett.bsky.social

Vega has joined the @pacbio.bsky.social “lego” family. #HiFi #DNA #LongReads

From low-pass seq that scales discovery to pangenomes that reveal hidden variation, long-read technologies are transforming genomics. Join PAG’s free webinar to explore insights reshaping research across the tree of life. Sponsored by #PacBio Register: bit.ly/4mbCkFU

Always excited for an increased salary submission! Congrats to the Department of Biological Sciences at New Jersey Institute of Tech for their stipend increase! This union-based win brings the pay almost to the 1:1 line! Update your department and find out more here: rhettrautsaw.app/shiny/Biolog...

Most RNA-seq methods feel like stir-fry. Transcripts diced into bits, then tossed back together. HiFi long reads bring the whole roast. Full transcripts served intact, end to end. Need to see how? Get the Seq 101 guide & a chance at a sponsored conference: bit.ly/3JminPa #TheresHiFiForThat

Looking to adopt long-read sequencing in your lab? The #PacBio Pre-Clinical Playbook has best practices, workflow guidance, case studies, and real-world insights to help you implement #HiFisequencing with confidence. 🔗 Download now: bit.ly/4mpZ85b

Get the most out of your HiFi data with @pacbio.bsky.social tools! Available for free on GitHub and bioconda/containers

Unlock the power of #PacBio HiFi whole genome sequencing in our 4-part video series. Learn from PacBio scientists as they walk through tools and examples for variant calling, tandem repeat analysis, paralogous gene resolution, and star (*)-allele calling. Sign up: bit.ly/3HV8Fmh

Curious how long-read sequencing is shaping drug discovery and development? Hear it from the experts. Join panelists from Pfizer, AstraZeneca, GSK, and more as they share how #PacBio HiFi sequencing is transforming the #biopharma industry. Register now: bit.ly/4m3L7KJ

Hi #Botany2025 - In my quest to never do flow cytometry again, I am collecting sequence data (radseq, target enrichment, WGS, ect.) with confirmed ploidal level. If you have samples, reach out!

#HiFisequencing is known for its accuracy, but did you know it can detect mutations as rare as 1 in 10 million base pairs? Authors from the U.S. FDA used it on #Revio to uncover ultralow-frequency mutations in TK6 and L5178Y cells, revealing what other methods often miss. Details: bit.ly/3TZZYts

Long-read sequencing is only as powerful as the software behind it. Learn how tools like SMRT Link help turn reads into results: bit.ly/3TJaBAQ Want to see SMRT Link Cloud in action? Register now for our webinar: bit.ly/40duRyc #PacBio #HiFisequencing #SMRTLinkCloud

At @miamiuniversity.bsky.social, students are using the #PacBio #Vega system to learn genomics through real experience. With access to #HiFisequencing workflows, they are gaining research skills and tackling projects once out of reach. Read more: bit.ly/3G5RPjX

180 SMRT Cells for one genome? That was 2011. Today, you can do it with just one. Watch how PacBio long-read tech has evolved from RS to Sequel to Revio and Vega. Because higher throughput and accuracy shouldn't be a trade-off. #TheresHiFiForThat

If you follow where genomics is headed, you’ll want to catch this early. We just wrapped a new interview series with some of the most forward-thinking scientists in the field. Sign up to be one of the first to watch: bit.ly/3FgEtAZ #PacBio #PacBioSPRQ

Focus your research on specific genes with #PacBio Targeted #HiFisequencing! Get cost-effective, scalable insights for tricky regions, accurate variants & phased haplotypes. Learn about PureTarget, HiFi Target Enrichment & PCR Amplicons. Watch now: bit.ly/3Het9pD#PacBio#HiFisequencing#PrecisionWithHiFi

Get more from your sequencing. #PacBio HiFi reads are long, accurate, and packed with insights—from variant detection to methylation—all in a single workflow. 🎥 Watch the video to see what makes it different: bit.ly/4msXbWJ #PrecisionWithHiFI #HiFisequencing

Friendly reminder: #PacBio wants to hear from you! Take our survey by Friday for a chance to win: 🎁 A complete, free Revio SPRQ sequencing run 💳 $1,000 PacBio coupon 🎉 $100 Amazon gift card (or equivalent) Take the survey: bit.ly/4cjoopZ Official rules are at the end of the survey.

That’s a wrap on #PacBioPRISM 2025 in Boston! Over two days, we welcomed 220+ attendees for impactful talks and great conversations. It was the perfect way to close out this year’s #PacBio PRISM series. Thanks to everyone who joined us — we’re excited for what’s ahead.

So fantastic to see an all women panel at #PacBioPRISM today moderated by @magdoll.bsky.social. #HiFi #longreads @pacbio.bsky.social

Day 2 of #PacBioPRISM 2025 in Boston was a huge success! Inspiring talks on rare disease, cancer genomics, and more showed how HiFi sequencing powers discoveries across science and medicine. So grateful to be part of this innovative community. One more day to go! #PacBio

Awesome talk today by Adam Healey from Hudson Alpha on tackling the sugarcane genome with @pacbio.bsky.social #HiFi #longreads.

Great talk today by @treangen.bsky.social from Rice University on the advantages of @pacbio.bsky.social #longread #hifi for #microbiome and #metagenomics research + assembly of the great horned owl.

This week's HiFi fun fact: the #PacBio HiFi Solves consortium is a global dream team of clinical researchers. 🌍   Can you guess how many institutions are repping this HiFi-powered squad?   Whatever the region. Whatever the research. #ThereHiFiForThat

From rare disease to reference-grade ape genomes, April’s Powered by #PacBio blog features studies in human health, evolution, agriculture & cancer—powered by #HiFiSequencing. See what researchers are uncovering with long-read data: bit.ly/3H3JxJb

Just wrapped #PacBioPRISM 2025 in San Francisco! 🌟 Grateful to connect with passionate scientists, innovators, and thought leaders pushing the boundaries of genomics with #PacBio. Thanks to all who made it unforgettable—next up: Boston!

Had a great time at #PacBioPRISM chatting to the community about the utility of reference genomes and the potential of long-read sequencing in conservation 🦊🐆🐺🐻 ! Some very inspirational talks and lots of potential applications to think about in the future!

🌟 Day 2 of #PacBioPRISM 2025 in San Francisco showcased groundbreaking research — from rare diseases and cancer to plant and animal genomics. Interactive workshops and networking sessions made it even more impactful. Proud to be part of a community driving innovation in science! #PacBio

Celebrating 25 years of big questions—like: What if researchers could actually see it all? We're kicking off a trivia series featuring rare disease wins, breakthroughs & proof that whatever the challenge, #TheresHiFiForThat. Which method uncovered 93% of the variants short reads missed? #PacBio

Join #PacBio at #ESHG2025 to explore scalable solutions for human disease research—from PureTarget panels to Kinnex RNA discoveries. 📍 Join us in Milan, 24–27 May. 📄 View the full agenda: bit.ly/3GG9wX7#PacBio#ESHG2025The future of sequencing starts with HiFi...

@pacbio.bsky.social instrument lounge at PRISM San Francisco event today! Great talks this morning and now we’re moving into parallel workshops.

After stops in Danang and Athens, the #PacBioPRISM global tour has arrived in San Francisco! 🇺🇸 We kicked off Day 1 with 25 years of #PacBio innovation and a powerful keynote from Sean Baumstark on resilience, purpose & living beyond limits. We’re just getting started!

Emily Farrow from Children’s Mercy Hospital is the first speaker on day 2 of @pacbio.bsky.social PRISM SF.

Berry Genomics is transforming single-gene disorder testing in China with #HiFisequencing. Their Thalassemia assay has boosted diagnosis rates and is now powered by the #Vega system. Read the full story: bit.ly/4iOussj#HiFisequencing#Vega#PacBio #ClinicalGenomics

It was great to attend PacBio Prism in Athens & hear from leading experts about the latest developments in LRS and how they are applying these technologies to bring real answers to patients especially in rare & complex diseases. 🇬🇷🧬✨ @pacbio.bsky.social @uclqsion.bsky.social

#PacBio and Chulalongkorn University announced a newborn screening research program using HiFi WGS in Thailand—the first in Asia Pacific at population scale. The study aims to show how genome-wide data can improve early detection of rare, treatable conditions. Details here: bit.ly/4jD0TuV

About NSF’s new(est) bulletin - 15% indirect cost rates will kill universities. Apparently that’s the point. I am sick.

Close to home. Go Miami!

#PacBioPRISM 2025 in Athens is a wrap — and what an unforgettable few days it’s been! Thank you to everyone who joined us. Together, we’re shaping the future of genomics. Congratulations again to our award winners—celebrating this community is always a true highlight. #PacBio

We’re proud to announce the PacBio Compatible partners sponsoring #PacBioPRISM 2025 in San Francisco and Boston. If you’re attending, don’t miss the chance to connect with these industry leaders onsite and explore how their technologies support and enhance #PacBio sequencing.

Thanks to everyone who stopped by the #PacBio booth at #AACR25! It was a great week of conversations around cancer research, long-read sequencing, and what’s next for HiFi. We’re proud to be part of the progress.

And really nice press release by @reginafairbanks.bsky.social www.amnat.org/an/newpapers...

Have you heard the news? @pacbio.bsky.social is expanding their methylation detection capabilities. Look at epigenome variation alongside your HiFi reads with no additional prep necessary!! Also…if you haven’t heard of Fiber-Seq…look it up. Forget about ATAC-Seq and start Fiber-Seq(ing).

192 years old—and still going strong. 🐢 What secrets lie in the DNA of the world’s oldest land animal? This #EarthDay, discover how sequencing Jonathan the tortoise is helping unlock the science of longevity. 🌍 Curious what makes Jonathan timeless? Read the preprint: bit.ly/4iikQWn

Excited to announce the winners of the 2024 SMRT Conserve Grant! 🌍🔬 This year’s grant supports endangered vertebrate species research with #PacBio HiFi sequencing + Hi-C. Thanks to all who applied—we're proud to back such vital conservation work.   Meet the winners: bit.ly/41QrBIQ

I didn't know PacBio maintained its own curation of sample/reference datasets. Saves me a bit of trouble of hunting down reliable ones for a pipeline testing: www.pacb.com/connect/data...