Excited to share our final accepted version of the CiFi method out today: www.nature.com/articles/s41...

Countdown starts now. The genomics series we’ve all been waiting for – a #PacBio original series. Trailer’s out. Premiere’s coming. Add it to your watchlist 👇 🔗 bit.ly/4oLrOXu

Annual Mabel with a Lego PacBio Sequencer. This time the Vega, but we also have the Revio and Sequel Lego edition.

Long-read genome sequencing is new first-tier generic test in diagnostics of rare diseases So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social. www.radboudumc.nl/en/news-item... (1/n)

SPRQ-Nx is coming to #Revio next year. It is expected to reduce whole genome sequencing costs by up to 40% to $300–$350 per genome or lower at scale. #PacBio #ASHG25 #HiFisequencing #ASHG

The #PacBioBlockParty is in full swing 🎉 Guests are rolling in, the music’s on, and the fun’s just getting started! Virtual darts, bowling, food, a live DJ, and more await. Let’s celebrate together!   #ASHG25 #PacBio #ASHG

PacBio: $300 Genome Via Chemistry Update 🧬🖥️ omicsomics.blogspot.com/2025/10/pacb...

Short reads…who needs em? Start bringing ALL your NGS projects into the long read era with cheaper sequencing, simultaneous methylation, greater insights, and more answers to your biological questions. PacBio’s got you covered.

Just in: #PacBio HiFi long-read sequencing is powering the National Institute on Aging’s Long Life Family Study. Up to 7,800 genomes and epigenomes will be sequenced on Revio systems to uncover rare variants, methylation patterns, and other factors linked to healthy aging. 🔗 bit.ly/3IUDdFo

I'm heading to Boston for #ASHG25 tomorrow, let me know if you'd like to chat about using HiFi sequencing for mitochondrial analyses, pharmacogenomics, or anything else! ICYMI, also happy to discuss our new Aardvark tool for benchmarking :)

We just released a major update for StarPhase that adds support for inexact matching PGx alleles. We're hoping this streamlines the process for discovering novel allele combinations with #PacBio #HiFi data, feedback welcome! Full notes here: github.com/PacificBiosc... #ASHG25

Updated tutorials for nQuack today. Want to predict ploidy level of sequence data? See this new tutorial on how to process and model data faster: mlgaynor.com/nQuack/artic...

In a landmark #PopulationGenomics study, All of Us researchers used #HiFisequencing of 1,027 participants to identify hundreds of #StructuralVariants disease associations, with over half missed by short reads. What are you missing in your research? Read the study here: bit.ly/4ocq49K #PacBio

Now published in Cell! We found that ~15% of SNPs from divergent refs did not liftover as SNPs in the gray fox ref—half mapped to monomorphic sites, half failed to map. Co-authored with Matthew Genchev, @elliecat.bsky.social, and @jazlynmooney.bsky.social www.sciencedirect.com/science/arti...

It absolutely warms my heart when I click on a pre-print that includes a bunch of top methods folks from industry and I see (1) open-source software (with a good license; MIT in this case) that is (2) written in Rust. Bravo @pacbio.bsky.social! Moar Rust plz! github.com/PacificBiosc...

I'm excited to share our pre-print about a new variant benchmarking tool we've been working on for the past few months! Aardvark: Sifting through differences in a mound of variants GitHub: github.com/PacificBiosc... Some highlights in this thread: 1/N

The 2025 #Epigenetics SMRT Grant is open! Submit a 100-word proposal for a chance to win free sequencing with Fiber-seq, which combines genome sequence, 5mC methylation, and chromatin accessibility for a multiomic view of regulation. Apply here: bit.ly/4nGQrEW

Today marks the first day in public media’s history without federal funding. And we’re not going anywhere. Listeners like you keep our mission alive. Protect one of the last places where America comes together to hear itself. Stand with us today. Donate at this link: n.pr/46wamAj

Did you know? Revio & Vega include on-instrument 6mA calling for the Fiber-seq chromatin accessibility assay. Thanks to Fiber-seq expert @mrvollger.bsky.social for the thoughtful evaluation and recommendation. Reagents for the assay are also available from our friends at EpiCypher: bit.ly/42YwGQE

Can one test replace many? A JAMA Pediatrics study by @childrensmercy.org evaluated long-read HiFi sequencing as a first-line approach for pediatric rare disease research, with potential to improve solves, reduce turnaround time, and bypass multiple sequential testing. Read more: bit.ly/3VtHjHh

🚨 Last call! This week, join PAG’s free webinar to see how long-read low-pass sequencing and pangenomes are reshaping #genomics. From structural variation to trait discovery, explore scalable insights across species. Sponsored by #PacBio. Register: bit.ly/4mbCkFU

The 2025 Long-Read Low Pass SMRT Grant for plant + animal sciences is now open! 🌱🐾 Apply to win free PacBio HiFi sequencing for your conservation or agricultural research. Submit your 100-word proposal today: bit.ly/3IgrReu #PacBio #SMRTGrant #HiFisequencing

Ready to celebrate #ASHG25? 🎉 Join us at the PacBio Block Party on October 15 in Boston to network with fellow scientists, connect with the genomics community, and honor 25 years of discoveries and innovation. RSVP now: bit.ly/46xnUeI#ASHG25 #PacBioBlockParty

New Editor's Choice article: "Island biogeography and competition drive rapid venom complexity evolution across rattlesnakes" by Hirst et al. doi.org/10.1093/evol... @hirsticane.bsky.social @RamsesRosales11.bsky.social @marcabeer.bsky.social @jason-strickland.bsky.social @reptilerhett.bsky.social

Vega has joined the @pacbio.bsky.social “lego” family. #HiFi #DNA #LongReads

From low-pass seq that scales discovery to pangenomes that reveal hidden variation, long-read technologies are transforming genomics. Join PAG’s free webinar to explore insights reshaping research across the tree of life. Sponsored by #PacBio Register: bit.ly/4mbCkFU

Always excited for an increased salary submission! Congrats to the Department of Biological Sciences at New Jersey Institute of Tech for their stipend increase! This union-based win brings the pay almost to the 1:1 line! Update your department and find out more here: rhettrautsaw.app/shiny/Biolog...

Most RNA-seq methods feel like stir-fry. Transcripts diced into bits, then tossed back together. HiFi long reads bring the whole roast. Full transcripts served intact, end to end. Need to see how? Get the Seq 101 guide & a chance at a sponsored conference: bit.ly/3JminPa #TheresHiFiForThat

Looking to adopt long-read sequencing in your lab? The #PacBio Pre-Clinical Playbook has best practices, workflow guidance, case studies, and real-world insights to help you implement #HiFisequencing with confidence. 🔗 Download now: bit.ly/4mpZ85b

Get the most out of your HiFi data with @pacbio.bsky.social tools! Available for free on GitHub and bioconda/containers

Unlock the power of #PacBio HiFi whole genome sequencing in our 4-part video series. Learn from PacBio scientists as they walk through tools and examples for variant calling, tandem repeat analysis, paralogous gene resolution, and star (*)-allele calling. Sign up: bit.ly/3HV8Fmh

Curious how long-read sequencing is shaping drug discovery and development? Hear it from the experts. Join panelists from Pfizer, AstraZeneca, GSK, and more as they share how #PacBio HiFi sequencing is transforming the #biopharma industry. Register now: bit.ly/4m3L7KJ

Hi #Botany2025 - In my quest to never do flow cytometry again, I am collecting sequence data (radseq, target enrichment, WGS, ect.) with confirmed ploidal level. If you have samples, reach out!

#HiFisequencing is known for its accuracy, but did you know it can detect mutations as rare as 1 in 10 million base pairs? Authors from the U.S. FDA used it on #Revio to uncover ultralow-frequency mutations in TK6 and L5178Y cells, revealing what other methods often miss. Details: bit.ly/3TZZYts

Long-read sequencing is only as powerful as the software behind it. Learn how tools like SMRT Link help turn reads into results: bit.ly/3TJaBAQ Want to see SMRT Link Cloud in action? Register now for our webinar: bit.ly/40duRyc #PacBio #HiFisequencing #SMRTLinkCloud

At @miamiuniversity.bsky.social, students are using the #PacBio #Vega system to learn genomics through real experience. With access to #HiFisequencing workflows, they are gaining research skills and tackling projects once out of reach. Read more: bit.ly/3G5RPjX

180 SMRT Cells for one genome? That was 2011. Today, you can do it with just one. Watch how PacBio long-read tech has evolved from RS to Sequel to Revio and Vega. Because higher throughput and accuracy shouldn't be a trade-off. #TheresHiFiForThat

If you follow where genomics is headed, you’ll want to catch this early. We just wrapped a new interview series with some of the most forward-thinking scientists in the field. Sign up to be one of the first to watch: bit.ly/3FgEtAZ #PacBio #PacBioSPRQ

Focus your research on specific genes with #PacBio Targeted #HiFisequencing! Get cost-effective, scalable insights for tricky regions, accurate variants & phased haplotypes. Learn about PureTarget, HiFi Target Enrichment & PCR Amplicons. Watch now: bit.ly/3Het9pD#PacBio#HiFisequencing#PrecisionWithHiFi

Get more from your sequencing. #PacBio HiFi reads are long, accurate, and packed with insights—from variant detection to methylation—all in a single workflow. 🎥 Watch the video to see what makes it different: bit.ly/4msXbWJ #PrecisionWithHiFI #HiFisequencing

Friendly reminder: #PacBio wants to hear from you! Take our survey by Friday for a chance to win: 🎁 A complete, free Revio SPRQ sequencing run 💳 $1,000 PacBio coupon 🎉 $100 Amazon gift card (or equivalent) Take the survey: bit.ly/4cjoopZ Official rules are at the end of the survey.

That’s a wrap on #PacBioPRISM 2025 in Boston! Over two days, we welcomed 220+ attendees for impactful talks and great conversations. It was the perfect way to close out this year’s #PacBio PRISM series. Thanks to everyone who joined us — we’re excited for what’s ahead.

So fantastic to see an all women panel at #PacBioPRISM today moderated by @magdoll.bsky.social. #HiFi #longreads @pacbio.bsky.social

Day 2 of #PacBioPRISM 2025 in Boston was a huge success! Inspiring talks on rare disease, cancer genomics, and more showed how HiFi sequencing powers discoveries across science and medicine. So grateful to be part of this innovative community. One more day to go! #PacBio

Awesome talk today by Adam Healey from Hudson Alpha on tackling the sugarcane genome with @pacbio.bsky.social #HiFi #longreads.

Great talk today by @treangen.bsky.social from Rice University on the advantages of @pacbio.bsky.social #longread #hifi for #microbiome and #metagenomics research + assembly of the great horned owl.

This week's HiFi fun fact: the #PacBio HiFi Solves consortium is a global dream team of clinical researchers. 🌍   Can you guess how many institutions are repping this HiFi-powered squad?   Whatever the region. Whatever the research. #ThereHiFiForThat

From rare disease to reference-grade ape genomes, April’s Powered by #PacBio blog features studies in human health, evolution, agriculture & cancer—powered by #HiFiSequencing. See what researchers are uncovering with long-read data: bit.ly/3H3JxJb

Just wrapped #PacBioPRISM 2025 in San Francisco! 🌟 Grateful to connect with passionate scientists, innovators, and thought leaders pushing the boundaries of genomics with #PacBio. Thanks to all who made it unforgettable—next up: Boston!

Had a great time at #PacBioPRISM chatting to the community about the utility of reference genomes and the potential of long-read sequencing in conservation 🦊🐆🐺🐻 ! Some very inspirational talks and lots of potential applications to think about in the future!