🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity By Patriotis et al., and the late David Allis ➡️ https://ow.ly/I7cp50YNGZs Agata Lemiesz Patriotis The Rockefeller University EpiCypher #epigenetic #histone #polycomb #lymphoma

Our new paper is out in Genes & Development! We found that a small domain in PRC2 — the SBD — isn't just structural scaffolding. It's a mechanical switch that powers the whole complex. Remove it, and cancers driven by EZH2 mutations stop growing. 🧵

We are hiring technicians! The Jacks Lab is a fun, exciting, and supportive place to learn and grow as a scientist- come study cancer with us! 🧬🐭 Apply here: careers.peopleclick.com/careerscp/cl...