As 2025 wraps up, we're proud to celebrate the inaugural year of the Journal of Human Immunity (JHI)! 🎉 Here are our 5 most-read articles so far 👇🧬

Mendelian susceptibility to mycobacterial disease: Clinical, immunological, and genetic study in India. New study from Aparna Dalvi, Manisha Madkaikar (Indian Council of Medical Research National Institute of Immunohaematology) and colleagues: rupress.org/jhi/article/... #Infections #Autoantibodies

Neurodevelopmental outcomes following hematopoietic cell transplantation for patients with severe combined immunodeficiency: A PIDTC study. From Virdette L. Brumm @ucsfchildrens.bsky.social, Ami J. Shah @stanfordmedicine.bsky.social and colleagues: rupress.org/jhi/article/... #SCID

#HowITreat: Infections and #InbornErrorsOfImmunity—Prevention, diagnosis, and treatment. New practical advice from Alexandra Freeman @niaidnews.bsky.social, Beth Thielen @thie0149.bsky.social, and Tamara Pozos @childrensminnesota.bsky.social: rupress.org/jhi/article/... @clinimmsoc.bsky.social

Extended clinical phenotypes and long-term outcomes of phosphoglucomutase-3 deficiency. New research letter from Chen Wang, Alexandra Freeman and colleagues @niaidnews.bsky.social: rupress.org/jhi/article/... #Autoimmunity #Atopy #ClinicalPhenotypes #InbornErrorsOfImmunity @clinimmsoc.bsky.social

Brumm, Shah et al. evaluated 69 subjects with #SCID to assess the neurodevelopmental outcomes following HCT. Compared with the normative population, our subjects performed in the average range. There was no impact of newborn screening, conditioning, or genotype. rupress.org/jhi/article/...

Dalvi, Madkaikar et al. describe 50 Indian patients w/ Mendelian susceptibility to #mycobacterial disease, highlighting its clinical diversity & genetic heterogeneity. Immunological assays, flow cytometry & genetic testing aid diagnosis & targeted clinical management rupress.org/jhi/article/...

Clinical experience with #emapalumab treatment in a group of children with primary hemophagocytic lymphohistiocytosis. A new study from Yulia Rodina et al.: rupress.org/jhi/article/... #Therapeutics #Hemophagocytosis

Freeman, Thielen @thie0149.bsky.social and Pozos provide practical advice on prevention, diagnosis, and management of infections in #InbornErrorsOfImmunity as well as management of common complications such as bronchiectasis. rupress.org/jhi/article/... #HowITreat @clinimmsoc.bsky.social

Registration for the 2026 CIS Annual Meeting in New Orleans is NOW OPEN! Secure your spot for our 40th Anniversary celebration. Registration and Hotel: https://cis.clinimmsoc.org/education/meetings/am26 #CIS2026

In new report, Wang, Freeman et al. summarize the clinical phenotypes, immunologic findings, treatment, and outcomes of 10 patients with Phosphoglucomutase-3 (PGM3) deficiency rupress.org/jhi/article/... @clinimmsoc.bsky.social

ICF syndrome: An epigenetic paradigm of primary immunodeficiencies. New review from Ricardo Martins-Ferreira and Esteban Ballestar @eballestar.bsky.social @carrerasijc.bsky.social: rupress.org/jhi/article/... #InbornErrorsOfImmunity #SevereImmunodeficiencies #BcellDeficiencies #SystemsImmunology

Yulia Rodina et al. explore the use of #emapalumab, an interferon gamma inhibitor, in seven children with primary hemophagocytic lymphohistiocytosis. rupress.org/jhi/article/... #Therapeutics #hemophagocytosis

Recurrent severe viral infection in a child with inherited complete TBK1 deficiency. New study from Sara Sebnem Kilic (Bursa Uludag University), Shuxiang Zhao (@rockefeller.edu) and colleagues: rupress.org/jhi/article/... @casanovalab.bsky.social @clinimmsoc.bsky.social #InbornErrorsOfImmunity

Martins-Ferreira and @eballestar.bsky.social @carrerasijc.bsky.social review how ICF syndrome serves as a paradigm of epigenetic #immunodeficiency. They show how alterations in DNA methylation and chromatin remodeling disrupt genome stability and B cell maturation. rupress.org/jhi/article/...

⏳ Deadline Tonight! ⏳ The deadline to submit your abstract for the #CIS2026 Annual Meeting is now Midnight tonight, December 15th. Don't miss your chance to present in New Orleans. 🔗 Submit today: https://cis.clinimmsoc.org/education/meetings/am26/abstracts#CIS2026#CIS #CISAM26 #AM26Abstracts

Applications for the CIS Foundation Scholar Experience Grants are now live! Apply now and take the next step in your professional journey. https://clinimmsoc.org/CIS/About/Foundation/CIS-Foundation-Scholar-Grants.htm #CISFoundation #ScholarExperienceGrants #CIS

The application window for FCIS (Fellows of the CIS) designation is closing soon. This is your opportunity to be recognized for your contributions. 📅 Deadline to Apply: 12/16/25 ➡️ Ready to apply? https://clinimmsoc.org/CIS/Resources/Fellows-of-the-CIS-.htm #FCIS #CareerGrowth #Immunology #CIS

⏳ Deadline Extended! ⏳ The deadline to submit your abstract for the #CIS2026 Annual Meeting is now Monday, December 15th. Don't miss your chance to present in New Orleans. Share your science with the world! 🔗 Submit today: https://cis.clinimmsoc.org/education/meetings/am26/abstracts#CIS2026 #CIS2026

⏳ Extended Deadline Today! The application deadline for the CIS–Grifols AIM Workshop is Today, December 8th Acceptance to the AIM Program comes with: ✈️ Round-trip airfare 🏨 3 nights lodging 🍽️ All meals Don't miss your chance. Apply now! 👉 https://clinimmsoc.org/.../2025-CISGrifols-AIM-Program.htm

🌟 Time is running out to nominate the next generation of CIS leaders! We're seeking nominations for: 🔹 One Councilor (3-year) 🔹 NEW Junior Councilor (2-year) for early-career professionals. Deadline: December 7! https://clinimmsoc.org/CIS/About/Leadership/Council-Nominations.htm

⏳ Deadline Approaching! The deadline to submit your abstract for the #CIS2026 Annual Meeting is Monday, December 8th. Don't miss your chance to present in New Orleans. Share your science with the world! Submit today: https://cis.clinimmsoc.org/education/meetings/am26/abstracts#CIS2026#ClinicalImmunology

Kilic, Zhao et al. report a child w/ a homozygous TBK1 mutation previously linked to #autoinflammation, suggesting its role in recurrent severe viral infections; the patient died from acute disseminated #encephalomyelitis. rupress.org/jhi/article/... @casanovalab.bsky.social @clinimmsoc.bsky.social

⏳ Extended Deadline Approaching! The application deadline for the CIS–Grifols AIM Workshop is now December 8th Acceptance to the AIM Program comes with: ✈️ Roundtrip airfare 🏨 3 nights lodging 🍽️ All meals Don't miss your chance. Apply now! 👉 https://clinimmsoc.org/.../2025-CISGrifols-AIM-Program.htm

It’s Giving Tuesday—a day to support the causes you care about. You can show support by publicly honoring a mentor who offered you guidance and opened doors. Honor Your Mentor Here: https://clinimmsoc.org/CIS/About/Foundation/Recognize-a-Mentor.htm

Novel de novo dominant PSMB10 variants in three patients with immune deficiency and liver disease. New study from Benjamin Fournier @hopitalnecker.bsky.social, Léa Poirier, Jean-Pierre de Villartay, Frédéric Ebstein @univ-nantes.fr and colleagues: rupress.org/jhi/article/... #InbornErrorsOfImmunity

Genotypes truncating the intracellular tail of human pre-TCR⍺: From amorphic to isomorphic. New report from Marie Materna, Vivien Béziat @vbeziat.bsky.social and colleagues: rupress.org/jhi/article/... @hopitalnecker.bsky.social @institutimagine.bsky.social #TcellDeficiencies

Automated data extraction model for the USIDNET registry: Bigger, faster, and better data collection. New study from Vaibhavi Vichare @childrensphila.bsky.social, Kathleen Sullivan ( Icahn School of Medicine at Mount Sinai) and colleagues: rupress.org/jhi/article/... @clinimmsoc.bsky.social

Human inborn errors of the alternative NF-κB pathway. New review from Tom Le Voyer, Jean-Laurent Casanova @casanovalab.bsky.social, and Anne Puel @anne-puel.bsky.social: rupress.org/jhi/article/... #InbornErrorsOfImmunity

This Thanksgiving, we want to express our gratitude to this amazing community. Thank you for your contributions and for the collaborative spirit that makes CIS so special.

Recognize a mentor you are thankful for! The Clinical Immunology Society (CIS) Foundation invites you to participate in its "Recognize a Mentor" program. This is an initiative to celebrate the mentors who guide and inspire us. Honor Your Mentor Here: https://lnkd.in/gQSUxmuR

Leniolisib reduced lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome. New study from Chopie Hassan, Kevin S. Thorneloe (Pharming Group) and colleagues: rupress.org/jhi/article/... #InbornErrorsOfImmunity

Application Deadline Extended! The application deadline for the CIS–Grifols AIM Workshop is now December 8th. Acceptance to the AIM Program comes with: ✈️ Roundtrip airfare 🏨 3 nights lodging 🍽️ All meals Apply now! 👉 https://clinimmsoc.org/CIS/Meetings/2025-CISGrifols-AIM-Program.htm

Our search for diagnostic tools for primary immune regulatory disorders (PIRD) continues. Join us in reading this outstanding article by Harris et al.: “T-cell and autoantibody profiling for primary immune regulatory disorders” https://www.jacionline.org/article/S0091-6749(25)00649-9/abstract

New review from Voyer, @casanovalab.bsky.social, & @anne-puel.bsky.social synthesizes human inborn errors of the alternative NF-κB pathway, highlighting their shared and distinct effects on lymphoid development, immune dysregulation, and mTEC-mediated tolerance rupress.org/jhi/article/...

⏳ TIME IS RUNNING OUT! ⏳ The deadline to submit your abstract for the #CIS2026 Annual Meeting is December 8th. Don't miss your chance to present in New Orleans. 🔗 Submit today: https://cis.clinimmsoc.org/education/meetings/am26/abstracts#CIS2026 #ClinicalImmunology #Abstracts #MedicalResearch

See a short video summary of the study by Kristine Jeganathan: youtu.be/7Kut4zWWTuk

New study from Hassan et al. examines the efficacy of leniolisib, a selective PI3Kδ inhibitor, in a murine model of ALPS, illustrating a reduction in lymphoproliferation and disease-associated biomarkers such as elevated double-negative T cells. rupress.org/jhi/article/... #InbornErrorsOfImmunity

IRF4 haploinsufficiency in a multiplex family with Whipple's disease. New report from Sinem Ünal, Stéphanie Dublanc, Jacinta Bustamante, Jérémie Rosain (@jrosain.bsky.social) and colleagues @hopitalnecker.bsky.social: rupress.org/jhi/article/... #InbornErrorsOfImmunity

Fournier @hopitalnecker.bsky.social, Poirier, Ebstein et al. report that novel dominant PSMB10 variants cause severe combined immunodeficiency and life-threatening liver disease in three pediatric patients. rupress.org/jhi/article/... #InbornErrorsOfImmunity #SevereImmunodeficiencies

In a new research letter, Materna, @vbeziat.bsky.social et al. identified six individuals with homozygous truncating variants in the pre-TCRα intracellular tail, revealing hypomorphic and neutral alleles. rupress.org/jhi/article/... @casanovalab.bsky.social @esidsociety.bsky.social

@childrensphila.bsky.social @clinimmsoc.bsky.social

⏳ Time is running out! The application deadline for the CIS–Grifols AIM Workshop is November 24. Acceptance to the AIM Program comes with: ✈️ Roundtrip airfare 🏨 3 nights lodging 🍽️ All meals Don't miss your chance. Apply now! 👉 https://clinimmsoc.org/CIS/Meetings/2025-CISGrifols-AIM-Program.htm

Ünal, Dublanc, Bustamante, @jrosain.bsky.social et al. @hopitalnecker.bsky.social report two patients with Whipple’s disease caused by autosomal dominant IRF4 deficiency. rupress.org/jhi/article/... @esidsociety.bsky.social #InbornErrorsOfImmunity

ORAI1 mutation with mixed loss- and gain-of-function properties causes #immunodeficiency and HLH, say Lucile Noyer (@Lucilenoyer.bsky.social) , Stefan Feske (@stefanfeske.bsky.social) and colleagues (NYU Grossman School of Medicine): rupress.org/jhi/article/... #InbornErrorsOfImmunity

Jeganathan, Pham-Huy et al. @uottawa.ca report that standard newborn screening using T cell receptor excision circles (TRECs) failed to detect delayed-onset ADA deficiency in two cases. But retrospective MS/MS analysis showed diagnostic deoxyadenosine elevation at birth. rupress.org/jhi/article/...

Nirmatrelvir/ritonavir use reduces risk for #longCOVID in patients with #immunodeficiency. New study from Karen Gilbert, Mei-Sing Ong, Jocelyn Farmer (Lahey Hospital) and colleagues: rupress.org/jhi/article/... #InbornErrorsOfImmunity #COVID19 #SARSCoV2

The landscape is changing, and industry collaboration is key. Don't miss your chance to join the CIS–Grifols AIM Program for a Clinical-Industry-Career Development Workshop this January in Austin, TX! Deadline is November 24th. 👉 https://clinimmsoc.org/CIS/Meetings/2024-CISGrifols-AIM-Program.htm

Calling all innovators in clinical immunology! The Clinical Immunology Society is now accepting abstracts for the 2026 Annual Meeting in New Orleans! Share your groundbreaking research on a premier stage. Submit today! 🔗 https://cis.clinimmsoc.org/education/meetings/am26/abstracts #CIS2026

A 𝘞𝘈𝘚 promoter variant underlying Wiskott-Aldrich syndrome in two kindreds. New report from Pauline Ober, Christelle Lenoir, Jérémie Rosain @jrosain.bsky.social and collegues @upcite.bsky.social @hopitalnecker.bsky.social: rupress.org/jhi/article/... #InbornErrorsOfImmunity #Diagnostics