Check out our new research letter!

🧪 #alzheimer #amyloid Amazing new paper from @sfackley.bsky.social that exposes the statistical alchemy Lilly applied to their donanemab data: jamanetwork.com/journals/jam... There is little to no correlation between amyoid removal and clinical outcomes with donanemab (or lecanemab).

Beware the reanalysis -

As a biostatistician, I agree.

This is awesome - yay epidemiology!

1) A covariate that is predictive of outcome should be in the model even if unpredictive of assignment (eg matched pairs design). 2) A covariate that is not predictive of outcome should not be in the model, even if predictive of assignment. 3) The propensity score is stupid.

Our new paper led by Yembe W. Njamnshi, MD while a GBHI Fellow @ UCSF. Using TabCAT assessment in Longitudinal Early Onset Alzheimer's Disease Study (LEADS) focusing on 3 different levels: convergent, diagnostic, & neuroanatomical validity: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Yeesh

Competition is extremely intense among top AI companies to achieve computing breakthroughs that might indicate the eternally imminent arrival of AGI, so a post like this from such a high-ranking executive caught the industry’s attention.

ICYMI: “And now, a response from the leader of the frog resistance...” 🐸 🎵 #Colbert

working on a new unified theory of american reality i'm calling "everyone is twelve now"

🔎 Meta-analysis and triangulation depend on credible science. 📈 TIME-AD’s latest paper, led by Dr. Sarah Ackley, examines 20,000+ abstracts using an LLM to determine whether P value trends reflect changes in p-hacking, publication bias, or statistical power. Read it: tinyurl.com/3f3nuxma

How left-handedness, learning differences, seizures, and autoimmune disease influence both the clinical presentation and age at onset of Alzheimer’s disease—So great to finally see this published: alz-journals.onlinelibrary.wiley.com/doi/epdf/10....

The Dutch for the win. #Disney #ABC latenighter.com/news/watch-d...

9/16/25 is a Pythagorean triple day! 3 squared + 4 squared = 5 squared! A right triangle. Read my classic story "The Square Root of Pythagoras" written with Paul Difilippo. www.rudyrucker.com/completestor...

Ugh - who taught this person statist?

haha thank you @rlgrant.bsky.social. It's ok though...memes should be free!

So true

Love this idea.

If you are in TimesSquare - see the billboard highlighting two of our UCSF Global Brain Health Fellows -amazing Elijah Rock sings songs you know by heart - and the artwork is by Kiggundu Rawdney. Have a listen. Funded in part by the Alzheimer’s Association.

WHO DID THIS?!? So amazing.

Maybe ChatGPT is just prescient and is predicting books these authors will write?

Resisting the urge to restart the negative binomial vs. Poisson wars...

Consider using a free textbook with your students- read the blog post:

From @bayviewanalytics.bsky.social on OER (Open Educational Resources) - The Many Factors Influencing OER Awareness and Use #EduSky @openstax.org hewlett.org openstax.org/blog/guest-p...

Feels like some more people around here might want to see this and share your feedback. I'm sure the folks at Heritage Foundation would appreciate your honest opinions.

Why else would universities be replacing all their epidemiologists with 'digital health scientists'?!

Dishonest charts are coming from all directions, and they're only going to hit harder. Unless we push back. So, an interactive guide: Defense Against Dishonest Charts flowingdata.com/projects/dis...

Check out my letter on amyloid-targeting drugs in STAT! www.statnews.com/2025/02/22/l... A thread #episky

Is it p-hacking or sample size and power? Take a look.

Duh

Great picture www.casino.org/vitalvegas/d...

Every time you write "there is no effect/difference (p>0.05)", when you mean "we found no evidence for an effect/difference (p>0.05)" a baby kitten dies