🚨 I share this case report, describing a case of late-onset dementia, associated with a likely pathogenic COL4A2 variant 👉 Late-onset dementia with leukoencephalopathy and a COL4A2 gene variant, causal link or fortuitous association: a case report www.sciencedirect.com/science/arti...

🧠 🚨 New publication in Scientific Reports ! 👉 Heterogeneity of white matter hyperintensities in Alzheimer’s disease captured by multimodal neuroimaging www.nature.com/articles/s41... 👉 We studied MRI (T1w, T2w) and PET (18F-florbetapir and 18F-FDG) signals within WMH in 142 older adults

🚨Postdoc position open at @BarcelonaBeta🚨 We're looking someone to work on a project at the intersection of cardiovascular and neurodegenerative research 🫀🧠 Fully funded position!!! More details: www.imim.cat/media/upload... Please share! #Alzheimer's #ENDALZ

🚨 Happy to share our commentary, on Sacubitril/Valsartan, Heart Failure and Risk of Dementia 🧠💊❤️ link.springer.com/article/10.1... The original paper link.springer.com/article/10.1... Our review in 2024 on this topic: alzres.biomedcentral.com/articles/10.... 🆘Brain & Heart health are connected 🧠❤️

🚨VasCog-2🚨 👉 Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria 🧠🩸🧠 jamanetwork.com/journals/jam...

🚨 Paper Alert Happy to share this review on intrinsic capacity (IC) in dementia with Lewy bodies 💪🧠 🔓 www.sciencedirect.com/science/arti...

🚨 VasCog 2025 🚨 👉 The conference of the International Society of Vascular Behavioural and Cognitive Disorders 🧠 Thrilled to participate in the upcoming #VASCOG2025 conference, where I will be delivering a talk on WMH in AD 💥 program online lnkd.in/dhhaAytZ @hcl-recherche.bsky.social

🧠🩺Comorbidities and comorbidity burden in patients with neurocognitive disorders 👉A detailed, in-depth study of comorbidities (individual comorbidities and comorbidity indices) in >3000 real-life patients seen in memory clinics💡 @hcl-recherche.bsky.social link.springer.com/article/10.1...

⛲💦🚰 👉"In this cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days."

My Substack. open.substack.com/pub/shibley/...

🚨 VasCog 2025 🚨 👉 The conference of the International Society of Vascular Behavioural and Cognitive Disorders 🧠 Thrilled to participate in the upcoming #VASCOG2025 conference, where I will be delivering a talk on WMH in AD 💥 program online lnkd.in/dhhaAytZ @hcl-recherche.bsky.social

🧠🩸Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis www.sciencedirect.com/science/arti...

🚨 Paper Alert Happy to share this review on intrinsic capacity (IC) in dementia with Lewy bodies 💪🧠 🔓 www.sciencedirect.com/science/arti...

What evidence do we have on the Social Determinants of Dementia (SDOD)? Delighted that this scoping review, a year or so in the making, is now published in @alzdemjournals.bsky.social. Expertly led by Anouk Geraets, we identified... doi.org/10.1002/alz.... 1/

A randomized trial (N>2,100 participants, multi-center) of structured vs self-guided lifestyle interventions in older adults shows the former improved cognitive function jamanetwork.com/journals/jam...

🧠🎈Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function The US POINTER RCT 👉The structured higher-intensity intervention had a greater benefit on global cognition than the self-guided low-intensity intervention. jamanetwork.com/journals/jam...

Donanemab receives positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in early symptomatic Alzheimer's disease investor.lilly.com/news-release...

🚀 Étude publiée sur les facteurs associés à la prescription d'une prise en soins en orthophonie 🗣️💬 en consultation mémoire 🧠 à partir des données de 574 patient-es ! www.jle.com/fr/revues/gp...

📢 Preprint alert! Check out the results of our international consensus effort which established research recommendations and identified high-priority future directions in the field of sleep, aging and dementia. Huge thank you to ISTAART and all collaborators for this tremendous team work ✨👇

Very happy to share our preprint on the associations between sleep disturbances and cholinergic PET imaging in older adults! 🧠 💤 👉 We found that higher REM sleep EEG slowing was associated with cholinergic denervation in older participants with and without MCI. #REMsleep #cholinergicsystem

LATE-NC and cerebrovascular disease associated with hippocampal sclerosis, not AD pathology (in models ajdusted for LATE) 👉Common neuropathologic change drivers of hippocampal sclerosis of ageing shorturl.at/Coxcb

Research Participant Interest in Learning Results of Biomarker Tests for AD 👉in this cohort study of 274 individuals with available biomarker data, 40% of participants declined the option to learn their AD research results shorturl.at/9Rbgv

🧠Exciting new findings from a great collaboration between the BioFINDER study and the talented @xiaoyucaly.bsky.social from @jwvogel.bsky.social group!! In their preprint, they show that tau presence and tau load are guided by unique brain mechanisms. Dive into the details here 👇

Neurodegeneration and the immune system: lessons from autoimmune encephalitis link.springer.com/article/10.1...

Brain health services for the secondary prevention of cognitive impairment and dementia: Opportunities, challenges, and the business case for existing and future facilities doi.org/10.1016/j.tj...

🧠💪🏿Assessment and management of frailty in individuals living with dementia: expert recommendations for clinical practice www.thelancet.com/journals/lan...

🚨 Great news for our GP colleagues and for the entire scientific and medical community ! 👇

Reducing the risk of all-cause dementia with intensive blood pressure control, the results of a cluster randomized trial in~34,000 participants. @naturemedicine.bsky.social www.nature.com/articles/s41...

🚨Happy to share this work from our team, led by Mohamed Nour Temedda & Virginie Dauphinot, on the association between comorbidites and nursing home admission in AD ! #MEMORA shorturl.at/pc1Mn @hcl-recherche.bsky.social

For the francophones out there, we've just launched a national online survey about social network use in adults and adolescents. Don't hesitate to participate (15-20 min) and spread the word! www.sual.fr/about-5 @juliadeter.bsky.social @joelbillieux.bsky.social @benjaminrolland.bsky.social

My paper reviewing how different neurodegenerative diseases affect autonomic function was just published.

A blockbuster study from Irene Papanicolas and colleagues linking wealth to mortality. - At every US wealth level., mortality rates were higher than Europe's - The wealthiest Americans have a survival rate similar to the poorest northern/western Europeans www.nejm.org/doi/full/10....

Thank you for the highlight and example case! With #LewyBody disease, posterior hypometabolism is often more prominent than atrophy. This could be related to changes in neuronal integrity of posterior networks by a-synuclein. academic.oup.com/brain/advance-article/doi/10.1093/brain/awae352/7906681

Just out in JAMA Neurol blood biomarkers are powerful—but without cognitive phenotyping, we risk more noise than signal. Plasma p-tau217 needs clinical context or we’ll end up in a false-positive factory! Clinico-biological AD is a reality! 👉🏻 jamanetwork.com/journals/jam... bsky.app/profile/vinc...

🚨Paper alert Very happy to share our last work on #IntrinsicCapacity (IC) in dementia with Lewy bodies #DLB (n=154), compared AD (n=644) 👉DLB patients showed lower IC in all domains (locomotion, vitality, psychology, audition), requiring personalized interventions ! 🔓 shorturl.at/EfrCX

Machine learning to discover factors predicting volume of white matter hyperintensities: Insights from the UK Biobank pubmed.ncbi.nlm.nih.gov/40135150/

WMH and repetitive head impacts : a novel pattern on FLAIR MRI? 🧠🏉🤼‍♀️ (1) small, punctate, non-confluent (2) spherical (3) proximal to the gray matter alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Happy to share the work of Vincent Bouteloup, which has just been published in JAMA Neurology and presented this morning at the AD/PD Conference! jamanetwork.com/journals/jam...

Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes www.nejm.org/doi/full/10....

🧠 Can dementia risk reduction policies cut costs and boost quality of life? New @nihr.bsky.social Evidence Article summarises Prof Naaheed Mukadam's paper, which shows the potential for interventions targeted at the population level to save money and quality of life years. buff.ly/TszCGUG

These interventions include, for example: 🧂 Legislation to reduce salt & sugar in food 💨 Introducing low emission zones 🚴‍♂️ Compulsory bike helmets for children. Read more: buff.ly/TszCGUG

2/2 Lifetime risk is higher for Women 48%, Black adults 44%, APOE ε4 carriers 59%. 📈 Annual U.S. dementia cases are projected to nearly double—from 514K to 1 million US citizens by 2060. Prevention & research are urgent priorities. Please repost & follow for more! doi.org/10.1038/s415...

💡Nouvelles recommandations 2025 pour le diagnostic de la maladie d’Alzheimer🧠 www.centres-memoire.fr/nouvelles-re...

Multiple Neuropathologies Underly Hippocampal Subfield Atrophy in a Case With a Slowly Progressive Amnestic Syndrome: Challenging the Notion of Pure LATE-NC onlinelibrary.wiley.com/doi/10.1111/...

🧠🏋️‍♀️Unraveling the link between frailty and Alzheimer’s disease biomarkers in patients with mild cognitive impairment link.springer.com/article/10.1...

🚨Paper alert Very happy to share our last work on #IntrinsicCapacity (IC) in dementia with Lewy bodies #DLB (n=154), compared AD (n=644) 👉DLB patients showed lower IC in all domains (locomotion, vitality, psychology, audition), requiring personalized interventions ! 🔓 shorturl.at/EfrCX

#MT180 | C’est l’heure des résultats ! Les candidates qualifiées pour l’étape régionale sont : 🥇 Chloé Chave, qui reçoit le 1er prix du jury ainsi que le prix du public 🥈 Noémie Dumont, qui reçoit le 2è prix du jury

🤝🧠Population-level interventions that target risk factors for dementia (eg blood pressure, smoking and obesity) save money and give people extra years in good health ! 🚀from individual-level 🏋️‍♀️ to population-level 🤝 interventions🫶! 👉🏼 Summary shorturl.at/6lD2O 👉🏼The modeling study shorturl.at/wAbpM