Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)

Our new paper (with @biotay.bsky.social) is out and on the cover story of @currentbiology.bsky.social !!!! Veronika, a Carinthian mountain cow flexibly uses a “multi-purpose tool” to scratch herself. A video and more information will follow in the comments. www.cell.com/current-biol...

CryoET of microbes inside an animal organ? Yes it’s possible! Check out our new preprint showing how we did it! What an amazing collaboration with amazing scientists who made this possible!

if you have to do MFA twice in the same "day": go to bed

Lokiarchaea are tricky to work with in the lab: they grow very slowly, exclusively in an oxygen free environment with the presence of symbiotic bacteria. But with careful nurturing, scientists hope to witness their cell division at work.

repurposing library monitors #upthearsenal

hot (well, cold) off the press! ❄️ well done @glynnca.bsky.social & @michaelgrange.bsky.social & fabulous co-authors 👏🏼 #teamtomo #cryoET

Delighted to see our work in press! 🙌🔬🧠 Thanks to @glynnca.bsky.social, @michaelgrange.bsky.social and the rest of the fabulous co-authors for all your contributions. Excited to see where in tissue structural cell biology goes next 👀! #liftlaughlove #teamtomo #whopper

inspiring and relatable talk from @alisterburt.bsky.social #ccpem

note to self: don't turn out of office replies on

Exploring shaped focused ion beams for lamella preparation https://www.biorxiv.org/content/10.1101/2025.04.01.646235v1

Check out our paper on Xenon milling of HPF samples, now online @naturecomms.bsky.social rdcu.be/eczIb

Barista: How caffeinated would you like to be? Me: Yes

Isolated in just 3 years! (previously, 12 years). We obtained two strains from 'Hodarchaeales', proposed to be closest to our archaeal ancestor. Our analysis suggests the ancestor was an anaerobic, syntrophic, peptidotrophic, archaeon with a simple intracellular structure and possible aerotolerance.

A great opportunity! (especially to hear @glynnca.bsky.social spread the plasma gospel🙌🏻)

Congrats Charlie & co.! The use of optogenetics for in tissue CLEM here is really elegant.

A long read from 2017 but well worth the time for any scientist who both loves their job and and often finds themselves questioning their life decisions. www.danielnettle.org.uk/wp-content/u...

We have quite a range of PhD projects this year, covering cryo-EM methods, bacteriology/bioenergetics, and infection/antibiotics/vaccines. Would really appreciate if people can RT and share with their teams!

Is there such thing as TEMTuesday? Maybe CryoETuesday? Myelinated axon cross section with microtubules and intermediate filaments:

it is nicer over here