Great week among the madness! 1. Genomic Arrhythmia Propensity Score (GAPS) paper accepted in principle. 2. Awarded the 2025 CDDRC Fellowship! 3. Shot 70 (-2) on Saturday 🤣⛳

Honored that @jclinical-invest.bsky.social invited me to provide some additional context for this innovative work by @bloodgenes.bsky.social

See you ALL at Weinstein tomorrow. Catch my talk on Thursday when I describe how we found evidence for noncoding variation contributing to ventricular arrhythmia/sudden cardiac arrest.

Looking forward to sharing some of my latest work at @weinsteinconf.bsky.social 2025! Of course, in addition to us, Milwaukee (the good land) has certainly had its share of visitors. It is also the only major American city to have ever elected three socialist mayors.

Can you hear it? We are all fish! Shouts to Dr. Gillis for helping to gill us. Terrific work. www.nature.com/articles/s41...

"These findings contribute to our understanding of the genetic complexity underlying CHD pathogenesis and emphasize the importance of investigating digenic interactions in other complex disorders." I concur. www.cell.com/ajhg/fulltex...

" However, too many patients remain gene-elusive, due to failure to employ comprehensive genetic diagnosis and limited insights into polygenic risk across diverse populations. " -stay tuned for my take on this problem hopefully out soon 😀 www.cell.com/cell/fulltex...

My big question re health and health research funding in the last few weeks is “why?” It makes no sense either politically, historically, or morally.

How to get 146% return on investment? The NIH. That's just the economic benefit. Biomedical research promotes human health.

It’s happening. Be prepared!

📢 AHA BCVS Early Career Webinar! Please join our upcoming webinar: "Jumpstart Your Independent Academic Career: Writing a Successful Transitional/Mentored Research Grant". We have an excellent panel with a center director, grant reviewers and K awardees! @ahascience.bsky.social

This, everyone. Choose your tools wisely! I am a major proponent of mouse work, but genomic context matters, and leverage anything unexpected for future discovery.

👨🏻‍🦰🔦

Important dialog going on here. When I first started diving into the primary ancient DNA literature, I was struck by how much world-building and storytelling comes out of seemingly sparse data... but maybe our genetics/cellbio discussion sections aren't any different! www.science.org/doi/10.1126/...

These are amazing. My favorite I saw once at UChicago’s ISAC is just a scribal student complaining - something like, “I’m really tired of practicing my writing, but teacher beats me when I stop.” Perfect decor for the lab!

happy to see this.. I happen to completely agree: www.cell.com/ajhg/fulltex...

Holey art thou

Come find me Saturday at the AHA Best of BCVS session to chat about genetic ventricular arrhythmia and how we can use AVAILABLE sequencing information to improve risk stratification… it will look a lot like last week at ASHG 🤓

Come find me at ASHG to chat about complex disease prediction and why I think we need to banish “genotype negative/positive” classifications. We can do better!

Hi blue sky! Here’s some candid footage of me showing the new rotation student around.