Just gotta say how much I appreciate simple little studies like this that save a lot of wasted energy looking for alternatives for patients that need meds while breastfeeding. So simple yet so reassuring. pubmed.ncbi.nlm.nih.gov/39405564/

It’s true what they say about reviewer 2! Time to fix up these manuscripts and resubmit, womp womp

Enjoying a nice comfy break from social media and capturing a couple top 3 finishes while that’s still achievable! Gotta get better about coming back here, feel like I’m just not as caught up with the latest lit these days!

podcasts.apple.com/us/podcast/b... This’ll be a great one!

These won’t last, but I’ll take the Ws and podiums when I can!

Is fifth third just like, the worst bank?

Dang, first manuscript rejected from JTACS. At least lots of helpful feedback, hopefully we can rework things a bit and get it accepted somewhere. Fingers still crossed on the prospective paper, hopefully that one makes it!

ONE ANTIBIOTIC PK TABLE TO RULE THEM ALL Absorption takes drug into blood from GI, Vd spreads drug out to where bug calls home. And after bacteria are doomed to die, The drug’s eliminated on the porcelain throne In the Land of Notion where this table doth lie… #idSky #microsky #pharmsky #medsky

Finally! Antibiotics are not non-inferior to appendectomy despite a generous 20% non-inferiority margin They are actually inferior: www.thelancet.com/journals/lan... in the @thelancet.bsky.social #MedSky

Also I must have misremembered, this study found a cut-off of 284 WBCs for older women with UTI academic.oup.com/cid/article/...

Love this since every lab I’ve seen has topped out at 200+! Think my current one is 180+, with abnormal lab reported at >8 😢

Important article for #AMSSky, #TxID, #UTISky, and #IDSky in @cidjournal.bsky.social: In neutropenic & non-neutropenic cancer patients w/ & w/o catheters, the absence of nitrite/leukocyte esterase or WBC<10 had high NPV for clinically significant bacteriuria academic.oup.com/cid/advance-...

🆕💫Multicenter retrospective study @cidjournal.bsky.social Impact of Fluconazole Resistance on the Outcomes of Patients With Candida parapsilosis Bloodstream Infections #idsky #EMIMCC academic.oup.com/cid/advance-...

NEW PREPRINT! Enjoyed working with @tom-parks.bsky.social and @petedodd24.bsky.social on immortal time bias In its simplest form, ITB results from misallocation of person time, i.e. pre treatment time in intervention group being counted as time on treatment www.medrxiv.org/content/10.1... [1/n]

Recent studies reinforce the benefits of oral antibiotics, as well as shorter durations of therapy in BJIs with supporting evidence 🆕💫 Review article Bone Voyage: Navigating Updates in the Management of Bone and Joint Infections #idsky link.springer.com/article/10.1...

What a cool study and a powerful demonstration that Tuberculosis is largely a disease of poverty. In Brazil a large scale intervention which provided cash monthly to families living in poverty led to profound reductions in TB cases. Up to 50% among the poorest groups. www.nature.com/articles/s41...

Though "Oral is the New IV" with antibiotics (h/t @bradspellberg.bsky.social), it's not always easy to convince reluctant inpatient clinicians -- especially (in my experience) surgeons, who want to treat "aggressively". Interesting dynamic ... blogs.jwatch.org/hiv-id-obser...

youtu.be/RRvYkrrpMKo?... Wow these are some absolute bops! Bunch of solid SNES era soundtracks on this guy’s channel too, on top of this one!

Oof what a miserable Hawkeye game

Use of voriconazole to predict susceptibility and resistance to isavuconazole for Aspergillus fumigatus using CLSI methods and interpretive criteria High rate of agreement suggests vori susceptibility can predict isa susceptibility in A fumigatus w/ CLSI AFST journals.asm.org/doi/10.1128/...

When AC is needed in acute cerebrovascular dz, heparin is usually chosen for its reversibility. Doses are often low-balled for safety, but does this come at a cost? Fast AC is needed in CSVT, and we saw that time to therapeutic PTT/AXa can >24h with low-intensity dosing! doi.org/10.1016/j.jo...

Can I just bag about a former resident for a bit? So cool to see her hard work featured after all the hurdles to get this far, but couldn’t be more proud! www.pharmacypracticenews.com/Online-First...

Thinking about splurging a bit in 2025, utilizing some healthcare. Something crazy like that!

Is it just me #pharmsky, or are Entresto tablets just purposefully annoying dose sizes to force more new prescriptions for dose changes and to make pharmacies carry all 3 strengths? I can’t think of another reason to market 24/26, 49/51, and 97/103mg tablets 🤨

WHAT

It’s finished, #pharmsky! I better have a plaque up at accp/bps after all this! 420 hours of fun, but can I do it again? That’s a 2030s problem now!

Is there an anti-Notre Dame broadcast? These espn jokers are way too much

Candida auris is a rapidly emerging fungal pathogen associated with high resistance rates! 🆕💫 Case report Successful Treatment of Candida auris Ventriculitis with Intravenous Liposomal Amphotericin B and Oral Flucytosine #idsky #EMIMCC academic.oup.com/ofid/advance...

🆕🔥OPTIMISE RCT 7 Vs 14d of Abx in severe MDR GN infections in ICU The trial could not determine the non-inferiority of 7d compared to 14d therapy for severe infections caused by MDR-GNB due to early termination related to low recruitment rate #idsky #EMIMCC ccforum.biomedcentral.com/articles/10....

Yes! Start here, and I'll attach a few more good ones shmpublications.onlinelibrary.wiley.com/doi/abs/10.1...

Nice to have a little guidance on AUC goals for other organisms!

endpts.com/astrazeneca-... Get dunked on, AZ

Just so happen to be writing about calcium use to reduce blood loss now, encouraging W for a simple intervention (in the subgroup 😅)

🔥🆕️CACTUS Multi center real world data on ceftaz/avi vs ceftol/tazo for MDR PsA bacteremia or pneumonia Overall similar clinical success including mortality, recurrent infection & resistance #idsky #EMIMCC #medsky www.thelancet.com/journals/lan...

The study we've all been eagerly waiting for is finally here! #idsky #EMIMCC

www.bmj.com/content/387/... Have not heard about this before, but very interesting read. Maybe it’s time that drug companies lose any control over clinical trials to obtain approval.

And, Steno...😍 At day 28, the clinical success rate of 53.3% was comparable to that observed in the pivotal phase 3 randomized trial and most retrospective observational studies. This indicates that immunosuppression is not a factor that impacts clinical success 🤔 #idsky

A graphic I think about way too much is this h pylori tx table. Pretty standard, but it answers a question I get occasionally - what to do for h pylori when you don’t have enteral access. Is HP really an acute problem that needs immediate tx? Not sure, but theres an option! #pharmsky #idsky

More ammo to keep flagyl q12h, this time for bactericides bacteremia! #IDsky #PharmSky www.sciencedirect.com/science/arti...

Wish I could be at this one!!

🔥The ADAPT-Sepsis RCT🔥 Daily PCT-guided protocol 🔽 total antibiotic duration & had noninferior all-cause mortality compared with standard care. No difference was found in total Abx duration between standard care & daily CRP-guided protocol CRP failure #idsky #EMIMCC jamanetwork.com/journals/jam...

WHO recommendations for management of serious bacterial infections in infants aged 0–59 days 8 December 2024 www.who.int/publications...

Most babies who got very sick from RSV the last few winters were previously healthy. jamanetwork.com/journals/jam...

Very excited to dig into this one

Check out the review of the COPY-ED Study on Apple Podcast at podcasts.apple.com/us/podcast/t...

Once again! Anidulafungin exposure and population pharmacokinetics in critically ill patients with invasive candidiasis Standard anidulafungin dosing is insufficient for achieving adequate exposure in critically ill patients Clinically?! #idsky #medsky ##EMIMCC link.springer.com/article/10.1...

The CDC lowered the recommended age for the 1-time vaccine against pneumonia. Previously recommended for those aged 65 years or older, the agency now advises the pneumococcal vaccination starting at age 50 years #idsky #medsky #EMIMCC jamanetwork.com/journals/jam...

So you want to get the bicarb level up before stopping the insulin gtt so that patients don't bounce back to ICU. I've been saying this for a decade and people usually think I'm nuts, but here is a paper that recently came out supporting it: pubmed.ncbi.nlm.nih.gov/37133440/

Ahh, finally , it's released , long awaited #idsky #medsky

Logitech could literally not fathom my sub Mb download speed