The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity. my.corehr.com/pls/uoxrecru...

This isn't a coincidence, IMO. The fly community is generally super rigorous - because there are so many tools and techniques available, people expect you to really nail things in order to get published (and keep getting funded)

What my brother @aheljo.bsky.social works on nowadays :)

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecru...

Happy to share a new little paper from our team - by @origichals.bsky.social et al. It describes a strategy to make SUMO1 more crystallisable by fusing it with a helper domain. Check out the nice ITC showing it still binds to SIM motifs. We are now working on co-crystallisation with SIM peptides.

A few years back we discovered a novel dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub): pubmed.ncbi.nlm.nih.gov/36197986/

Happy that my work on RNF213 has been published as a part of doi.org/10.1038/s414...! Many thanks to all the groups involved: @clausenlab.bsky.social @e3chembio.bsky.social @fletcherlab.bsky.social Have a look at the summary from Fletcher lab for an insider perspective of the paper's history: