Mateusz Konczal
@mkonczal.bsky.social
📤 160
📥 166
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Evolutionary and population genomics Assistant Professor in Poznan, Poland 🇵🇱
pinned post!
Our latest preprint shows that in translocated invasive guppy population, genetic load is reshaped by purging and admixture. A bottleneck purged strongly deleterious mutations, but admixture reversed this effect while reducing the load of weakly deleterious mutations.
www.biorxiv.org/content/10.1...
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Interplay between purging and admixture shapes genetic load in an invasive guppy population
Demographic history can shape the genetic load of populations by influencing the efficacy of selection, levels of heterozygosity, and by incorporation of new variants via gene flow. Understanding thes...
https://www.biorxiv.org/content/10.1101/2025.09.12.675788v1
8 months ago
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Our new paper on genetic rescue is now out in Nature Ecology & Evolution! Huge kudos to Jon — it was an amazing experience working on this project. Check out our results!
www.nature.com/articles/s41...
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2 days ago
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Mateusz Konczal
Nandita Garud
18 days ago
Our paper entitled "The persistence and loss of hard selective sweeps amid admixture in ancient Eurasians" is now out in PNAS!
www.pnas.org/doi/abs/10.1...
. A really fun and informative collaboration with
@mharris.bsky.social
, Ziyi Mo and Adam Siepel. (1/n)
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The persistence and loss of hard selective sweeps amid admixture in ancient Eurasians | PNAS
The extent to which human adaptations have persisted throughout history despite strong eroding demographic events such as admixture, genetic drift,...
https://www.pnas.org/doi/abs/10.1073/pnas.2528672123
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Mateusz Konczal
Scott V. Edwards
about 1 month ago
Ver excited to share my just-published Darwin Review with
@lh3lh3.bsky.social
on population-scale long-read sequencing!
royalsocietypublishing.org/rspb/article...
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Population-scale long-read DNA sequencing: peering under the hood of the new evolutionary genomics
Abstract. Population-scale long-read DNA sequencing (PLRS) is rapidly reshaping our understanding of genomic variation in humans and non-model species. In
http://royalsocietypublishing.org/rspb/article/293/2069/20252899/481431/Population-scale-long-read-DNA-sequencing-peering
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Mateusz Konczal
Molly Schumer
about 1 month ago
Please share widely! We will imminently be posting a technician position in our lab group since
@rheasood.bsky.social
is off to grad school 🙌! If you know of anyone excited about molecular biology, evolution, and functional genomics please have them reach out (schumer at stanford). Start date ~June
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Our new paper about polymorphism in a key regulator of missing-self innate immunity is now available in
@molbioevol.bsky.social
Congratulations
@rocconotarnicola.bsky.social
et al!
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about 1 month ago
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Mateusz Konczal
Centre for Palaeogenetics
about 1 month ago
We present DNAharvester 🎉🦴🚜🧬 A pipeline to process highly degraded ancient DNA data that integrates metagenomic filtering, competitive mapping, multiple alignment strategies, reference bias evaluation and much more. GitHub:
github.com/NBISweden/DN...
Preprint:
www.biorxiv.org/content/10.6...
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reposted by
Mateusz Konczal
Evolutionary Biology Group, Adam Mickiewicz University
about 1 month ago
New work by Neha Pandey and the group on sexual selection’s role in population resilience, dynamics & recovery is now out.
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Mateusz Konczal
Neelam Porwal
about 2 months ago
The second chapter of my PhD is now available as a preprint 🦚. A lot of it came together during long days in front of my blue screen, and weekends spent watching puffins in the UK. With an amazing team
@robknell.bsky.social
@jacek-radwan.bsky.social
Jonathan Parrett and
@ecologycoder.bsky.social
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Mateusz Konczal
EvoBioLMU
3 months ago
@jochenwolflab.bsky.social
Where do potentially harmful mutations accumulate? We have an answer in birds. Congratulations Fidel for wonderful paper!
doi.org/10.1093/gene...
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Determinants of mutation load in birds
Abstract. Many mutations have detrimental effects. The mutation load in a population depends on the efficacy of purifying selection in removing deleterious
https://doi.org/10.1093/genetics/iyag033
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📢 PhD position – Evolutionary & Conservation Genomics We invite applications for a 48-month PhD in the project “Genetic load and adaptive potential of European bison.”
evobio.web.amu.edu.pl/2026/01/27/p...
#PhD
#Genomics
#ConservationGenomics
#EvolutionaryBiology
#aDNA
4 months ago
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Mateusz Konczal
bioRxiv Evolutionary Biology
5 months ago
A key regulator of missing-self innate immunity is polymorphic and under diversifying selection
https://www.biorxiv.org/content/10.64898/2025.12.10.693425v1
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Mateusz Konczal
bioRxiv Evolutionary Biology
5 months ago
Genomic basis of adaptation to constant and fluctuating environments in a global pest of cereals
https://www.biorxiv.org/content/10.64898/2026.01.08.698337v1
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🦬 🦬 🦬
add a skeleton here at some point
6 months ago
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[PL] Dobry tekst o polskich jednorożcach, a w istocie o znaczeniu badań podstawowych:
wszystkoconajwazniejsze.pl/andrzej-dybc...
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Andrzej DYBCZYŃSKI: Bajki o polskich jednorożcach
Olga Malinkiewicz i jej Saule Technologies i perowskitach po programie, jaki Krzysztof Stanowski zaproponował w Kanał Zero.
https://wszystkoconajwazniejsze.pl/andrzej-dybczynski-bajki-o-polskich-jednorozcach-olga-malinkiewicz/
6 months ago
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Mateusz Konczal
bioRxivpreprint
7 months ago
Maternal antibody-mediated elimination of a Puumala hantavirus outbreak in a bank vole colony
https://www.biorxiv.org/content/10.1101/2025.11.04.686465v1
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Our latest paper with
@evobiolab.bsky.social
shows sex-specific recombination landscape in a species with holocentric chromosomes. Genetic map of the bulb mite, results consistent with meiotic drive hypothesis and much more. Congrats to Sebastian for tremendous work
academic.oup.com/genetics/art...
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Sex-specific recombination landscape in a species with holocentric chromosomes
Abstract. The rate and chromosomal positioning of meiotic recombination significantly affects the distribution of the genetic diversity in eukaryotic genom
https://academic.oup.com/genetics/article-abstract/doi/10.1093/genetics/iyaf217/8287322
7 months ago
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Mateusz Konczal
Toni Gabaldón
8 months ago
Including a position in my group to work on Evolutionary Genomics of Fungal pathogens
add a skeleton here at some point
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Mateusz Konczal
Graham Coop
7 months ago
Congratulations to
@jeffgroh.bsky.social
on the publication of his paper on an ancient balanced polymorphisms controlling heterodichogamy in two genera of wingnuts. The paper shows the putative turnover & reversal of dominance of a mating type polymorphism
www.sciencedirect.com/science/arti...
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Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts
In the angiosperm mating system of heterodichogamy, two hermaphroditic morphs temporally alternate between male and female flowering phases, promoting…
https://www.sciencedirect.com/science/article/pii/S0960982225012618?dgcid=coauthor
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Mateusz Konczal
Reto Burri
7 months ago
1/9 New in
@science.org
www.science.org/doi/10.1126/science.ado8005
How does genetic architecture constrain evolutionary trajectories? To address this question, we inferred the genetic architecture of convergent plumage coloration and its evolutionary history in wheatears.
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A mosaic of modular variation at a single gene underpins convergent plumage coloration
The reshuffling of genomic variation from multiple origins is an important contributor to phenotypic diversification, yet insights into the evolutionary trajectories of this combinatorial process and ...
https://www.science.org/doi/10.1126/science.ado8005
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Mateusz Konczal
Erle Ellis
8 months ago
Anthropocene Canceled? 🚯
@ecosocialism1.bsky.social
monthlyreview.org/articles/has...
>>> Of course NOT <<< The evidence speaks for itself. No geologists, epochs or hype required.
theconversation.com/the-anthropo...
🌍⚒️🌐🧪
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Mateusz Konczal
Matthew Neville
8 months ago
Now published! Our paper on: (1) Accurate sequencing of sperm at scale (2) Positive selection of spermatogenesis driver mutations across the exome (3) Offspring disease risks from male reproductive aging [1/n]
www.nature.com/articles/s41...
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Sperm sequencing reveals extensive positive selection in the male germline - Nature
A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.
https://www.nature.com/articles/s41586-025-09448-3
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"Potato, potato; tomato, tomahto" but the potato evolved from the tomato 9 millions years ago 🤓
www.cell.com/news-do/pr-p...
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The potato evolved from the tomato 9 million years ago
Recent Cell research covered by The Guardian, The New York Times, The Atlantic, and more.
https://www.cell.com/news-do/pr-potato-tomato-evolution
8 months ago
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Mateusz Konczal
Piotr Ziolkowski
8 months ago
🚀 We’re hiring a Postdoc! Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome! 📅 Deadline: Nov 1, 2025 🔗
ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
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One of my favourite examples for
#conservation
#genetics
classes. It reminds me that with October
#TeachingIsComming
add a skeleton here at some point
8 months ago
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Mateusz Konczal
KevinDKohl
8 months ago
Pleased to share new work tinkering with and testing the concept of the holobiont
@isme-microbes.bsky.social
"Experimental evolution of a mammalian holobiont: bank voles selected for herbivorous capability evolved distinct and robust gut bacterial communities" 🌾🐭🦠
academic.oup.com/ismecommun/a...
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Experimental evolution of a mammalian holobiont: bank voles selected for herbivorous capability evolved distinct and robust gut bacterial communities
Abstract. According to the “hologenome” theory of evolution natural selection and evolution can act through a conglomerate biological unit, the “holobiont”
https://academic.oup.com/ismecommun/advance-article/doi/10.1093/ismeco/ycaf160/8251380
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reposted by
Mateusz Konczal
bioRxiv Evolutionary Biology
8 months ago
Interplay between purging and admixture shapes genetic load in an invasive guppy population
https://www.biorxiv.org/content/10.1101/2025.09.12.675788v1
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Our latest preprint shows that in translocated invasive guppy population, genetic load is reshaped by purging and admixture. A bottleneck purged strongly deleterious mutations, but admixture reversed this effect while reducing the load of weakly deleterious mutations.
www.biorxiv.org/content/10.1...
loading . . .
Interplay between purging and admixture shapes genetic load in an invasive guppy population
Demographic history can shape the genetic load of populations by influencing the efficacy of selection, levels of heterozygosity, and by incorporation of new variants via gene flow. Understanding thes...
https://www.biorxiv.org/content/10.1101/2025.09.12.675788v1
8 months ago
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reposted by
Mateusz Konczal
Marianna Karageorgi
8 months ago
How do populations maintain an evolutionary memory? I am happy to share that our work with Dmitri Petrov
@petrovadmitri.bsky.social
, Paul Schmidt, and colleagues on dominance reversal and stabilization of insecticide resistance in changing environments over time is now published at Nature EE.
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Beneficial reversal of dominance maintains a large-effect resistance polymorphism under fluctuating insecticide selection - Nature Ecology & Evolution
Measuring selection and dominance in fitness of the insecticide-resistant Ace alleles in Drosophila melanogaster, the authors show evidence for beneficial reversal of dominance, a mechanism that can s...
https://www.nature.com/articles/s41559-025-02853-x
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reposted by
Mateusz Konczal
bioRxiv Evolutionary Biology
8 months ago
Fighting to persist: Genetic rescue increases long-term fitness despite elevated genetic load
https://www.biorxiv.org/content/10.1101/2025.09.06.673525v1
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Check out our latest work! We experimentally showed that
#genetic
#rescue
works: in the bulb mites, boosting genome-wide variation improved survival for 20 generations in high temp. Elevated genetic load or sexually selected traits? Barely mattered.
#Conservation
www.biorxiv.org/content/10.1...
8 months ago
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reposted by
Mateusz Konczal
Evolutionary Biology Group, Adam Mickiewicz University
8 months ago
@neelamporwal.bsky.social
‘s talk about estimating extinction risks under sexual selection using simulations, at PEC2025 won the first prize for the best student talk. So, should animals swipe right for survival?🐧
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Mateusz Konczal
Fausto Rodríguez Zapata
9 months ago
Enhancing local meiotic crossovers in Arabidopsis and maize through juxtaposition of heterozygous and homozygous regions | Nature Plants
share.google/ZsqLLUu9l2Zv...
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Enhancing local meiotic crossovers in Arabidopsis and maize through juxtaposition of heterozygous and homozygous regions - Nature Plants
This study discovered that locally confined DNA differences boost crossover rates in both Arabidopsis and maize, revealing a conserved mechanism that can accelerate plant breeding and trait introgress...
https://share.google/ZsqLLUu9l2ZvoKo4j
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reposted by
Mateusz Konczal
Rayan Chikhi
9 months ago
🌎👩🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.
doi.org/10.1101/2024...
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Mateusz Konczal
Clàudia Fontserè
9 months ago
This is now published at
#MolecularEcology
onlinelibrary.wiley.com/doi/10.1111/...
Check it out!
add a skeleton here at some point
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Mateusz Konczal
Katerina Guschanski
9 months ago
Fantastic dental calculus and where to find it Johnny Richards and team (
@markella-morait.bsky.social
+ curators from 5 museums) survey >140 mammalian species with >1,600 specimens to understand what factors determine dental calculus formation.
#aDNA
#museomics
www.biorxiv.org/content/10.1...
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Mateusz Konczal
Jacek Radwan
10 months ago
If you are frustrated with the quality of reviews and excessive article processing charges, take a minute read:
trulyopenscience.blogspot.com/2025/07/a-si...
We researchers really have a power to change this!
#ScientificPublishing
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A simple recipe for a truly open, prestigious, society-owned journal
Is there anything wrong with the current model of scientific publishing, and, if so, can we, practising researchers, do anything about it? I...
https://trulyopenscience.blogspot.com/2025/07/a-simple-recipe-for-truly-open.html
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Mateusz Konczal
Erik Postma
9 months ago
With
#eseb2025
coming to a close, it is time to start making plans for 2026. Interested in the interface of evolution 🧬 and ecology 🌳? Come to our
#ExE
conference hosted by
@uniexecec.bsky.social
in beautiful
#Cornwall
. Leave your email address at
tinyurl.com/EvolxEcol
to join our mailing list!
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Small update: Plenaries and Nosil talks: "Nature/Science" in the bottom right of a slide
#eseb2025
add a skeleton here at some point
9 months ago
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Mateusz Konczal
Evolutionary Biology Group, Adam Mickiewicz University
9 months ago
We are having fantastic time presenting and discussing our work at
#ESEB2025
- Neelam Porwal answered a question "How sexual selection shapes small populations demography under recurrent heatwaves"
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#eseb2025
talks were great so far. Subjective ranking of the most common quotes: - theory and modeling: "with this very simple approach" - genomics: "using methodology you all know" - plenaries: "Nature/Science" in the bottom right of a slide - posters: "una cerveza por favor"
9 months ago
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Mateusz Konczal
Molecular Biology and Evolution
about 1 year ago
Stuart et al. show footprints of selection after near-extinction: genetics of wild and captive Lord Howe stick insect show that after a severe bottleneck, inbreeding appears to remove harmful mutations via increased homozygosity. 🔗
doi.org/10.1093/molb...
#selection
#evobio
#molbio
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Purging of Highly Deleterious Mutations Through an Extreme Bottleneck
Abstract. Transitions to captivity often produce population bottlenecks. On the one hand, bottlenecks increase inbreeding and decrease effective population
https://doi.org/10.1093/molbev/msaf079
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"Dissertationibus conscriptis et publice defensis." What a day it was! Congratulations
@k-burda.bsky.social
So proud of you
add a skeleton here at some point
about 1 year ago
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Here we come! A shiny profile of our group is on. Exciting news are coming soon
add a skeleton here at some point
about 1 year ago
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Mateusz Konczal
Chris Jiggins
about 1 year ago
Excited about these new results on a butterfly-plant arms race where one butterfly has overcome a physical plant defence - hooked trichomes- with a combination of external and internal adaptations. Well done
@ritabrata1907.bsky.social
add a skeleton here at some point
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Mateusz Konczal
Nicolas Dussex
about 1 year ago
I am looking for a Postdoc (3 years, start Mid-2025) to work on conservation genomics of ringed seal in the Baltic. The project will use genomic data for 100s of individuals, SDM and genomic simulations.
#conservationgenetics
#consgen
Apply here:
recruit.visma.com/spa/public/a...
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Hidden gems
#Bialowieza
#wisent
#skull
over 1 year ago
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Mateusz Konczal
Molly Przeworski
over 1 year ago
“The distribution of highly deleterious variants across human ancestry groups”. Preprint with Anastasia Stolyarova and
@gcbias.bsky.social
:
www.biorxiv.org/content/10.1...
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The distribution of highly deleterious variants across human ancestry groups
A major focus of human genetics is to map severe disease mutations. Increasingly that goal is understood as requiring huge numbers of people to be sequenced from every broadly-defined genetic ancestry...
https://www.biorxiv.org/content/10.1101/2025.01.31.635988v1
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Every third de novo mutation is lost immediately after appearance, irrespective of population size: (1 - 1/2N)^2N ~ e^-(2N/2N) ~ 0.368
over 1 year ago
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"The evolutionary ecology of ethanol" - I don't know, but sounds somehow intriguing
www.cell.com/trends/ecolo...
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The evolutionary ecology of ethanol
The consumption of ethanol has frequently been seen as largely restricted to humans. Here, we take a broad eco-evolutionary approach to understanding ethanol’s potential impact on the natural world. There is growing evidence that ethanol is present in many wild fruits, saps, and nectars and that ethanol ingestion offers benefits that favour adaptations for its use in multiple taxa. Explanations for ethanol consumption span both the nutritional and non-nutritional, with potential medicinal value or cognitive effects (with social–behavioural benefits) explored. We conclude that ethanol is ecologically relevant and that it has shaped the evolution of many species and structured symbiotic relationships among organisms, including plants, yeast, bacteria, insects, and mammals.
https://www.cell.com/trends/ecology-evolution/fulltext/S0169-5347(24)00240-4
over 1 year ago
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Mateusz Konczal
Graham Coop
over 1 year ago
Congrats to
@jeffgroh.bsky.social
et al on publication of "Ancient structural variants control sex-specific flowering time morphs in walnuts and hickories"
www.science.org/doi/10.1126/...
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