Mateusz Konczal
@mkonczal.bsky.social
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📥 161
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Evolutionary and population genomics Assistant Professor in Poznan, Poland 🇵🇱
pinned post!
Our latest preprint shows that in translocated invasive guppy population, genetic load is reshaped by purging and admixture. A bottleneck purged strongly deleterious mutations, but admixture reversed this effect while reducing the load of weakly deleterious mutations.
www.biorxiv.org/content/10.1...
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Interplay between purging and admixture shapes genetic load in an invasive guppy population
Demographic history can shape the genetic load of populations by influencing the efficacy of selection, levels of heterozygosity, and by incorporation of new variants via gene flow. Understanding thes...
https://www.biorxiv.org/content/10.1101/2025.09.12.675788v1
4 months ago
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🦬 🦬 🦬
add a skeleton here at some point
22 days ago
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[PL] Dobry tekst o polskich jednorożcach, a w istocie o znaczeniu badań podstawowych:
wszystkoconajwazniejsze.pl/andrzej-dybc...
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Andrzej DYBCZYŃSKI: Bajki o polskich jednorożcach
Olga Malinkiewicz i jej Saule Technologies i perowskitach po programie, jaki Krzysztof Stanowski zaproponował w Kanał Zero.
https://wszystkoconajwazniejsze.pl/andrzej-dybczynski-bajki-o-polskich-jednorozcach-olga-malinkiewicz/
29 days ago
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Mateusz Konczal
bioRxivpreprint
about 2 months ago
Maternal antibody-mediated elimination of a Puumala hantavirus outbreak in a bank vole colony
https://www.biorxiv.org/content/10.1101/2025.11.04.686465v1
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Our latest paper with
@evobiolab.bsky.social
shows sex-specific recombination landscape in a species with holocentric chromosomes. Genetic map of the bulb mite, results consistent with meiotic drive hypothesis and much more. Congrats to Sebastian for tremendous work
academic.oup.com/genetics/art...
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Sex-specific recombination landscape in a species with holocentric chromosomes
Abstract. The rate and chromosomal positioning of meiotic recombination significantly affects the distribution of the genetic diversity in eukaryotic genom
https://academic.oup.com/genetics/article-abstract/doi/10.1093/genetics/iyaf217/8287322
2 months ago
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Mateusz Konczal
Toni Gabaldón
3 months ago
Including a position in my group to work on Evolutionary Genomics of Fungal pathogens
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Mateusz Konczal
Graham Coop
3 months ago
Congratulations to
@jeffgroh.bsky.social
on the publication of his paper on an ancient balanced polymorphisms controlling heterodichogamy in two genera of wingnuts. The paper shows the putative turnover & reversal of dominance of a mating type polymorphism
www.sciencedirect.com/science/arti...
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Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts
In the angiosperm mating system of heterodichogamy, two hermaphroditic morphs temporally alternate between male and female flowering phases, promoting…
https://www.sciencedirect.com/science/article/pii/S0960982225012618?dgcid=coauthor
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Reto Burri
3 months ago
1/9 New in
@science.org
www.science.org/doi/10.1126/science.ado8005
How does genetic architecture constrain evolutionary trajectories? To address this question, we inferred the genetic architecture of convergent plumage coloration and its evolutionary history in wheatears.
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A mosaic of modular variation at a single gene underpins convergent plumage coloration
The reshuffling of genomic variation from multiple origins is an important contributor to phenotypic diversification, yet insights into the evolutionary trajectories of this combinatorial process and ...
https://www.science.org/doi/10.1126/science.ado8005
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Mateusz Konczal
Erle Ellis
3 months ago
Anthropocene Canceled? 🚯
@ecosocialism1.bsky.social
monthlyreview.org/articles/has...
>>> Of course NOT <<< The evidence speaks for itself. No geologists, epochs or hype required.
theconversation.com/the-anthropo...
🌍⚒️🌐🧪
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Mateusz Konczal
Matthew Neville
3 months ago
Now published! Our paper on: (1) Accurate sequencing of sperm at scale (2) Positive selection of spermatogenesis driver mutations across the exome (3) Offspring disease risks from male reproductive aging [1/n]
www.nature.com/articles/s41...
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Sperm sequencing reveals extensive positive selection in the male germline - Nature
A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.
https://www.nature.com/articles/s41586-025-09448-3
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"Potato, potato; tomato, tomahto" but the potato evolved from the tomato 9 millions years ago 🤓
www.cell.com/news-do/pr-p...
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The potato evolved from the tomato 9 million years ago
Recent Cell research covered by The Guardian, The New York Times, The Atlantic, and more.
https://www.cell.com/news-do/pr-potato-tomato-evolution
3 months ago
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Piotr Ziolkowski
3 months ago
🚀 We’re hiring a Postdoc! Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome! 📅 Deadline: Nov 1, 2025 🔗
ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
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One of my favourite examples for
#conservation
#genetics
classes. It reminds me that with October
#TeachingIsComming
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3 months ago
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Mateusz Konczal
KevinDKohl
4 months ago
Pleased to share new work tinkering with and testing the concept of the holobiont
@isme-microbes.bsky.social
"Experimental evolution of a mammalian holobiont: bank voles selected for herbivorous capability evolved distinct and robust gut bacterial communities" 🌾🐭🦠
academic.oup.com/ismecommun/a...
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Experimental evolution of a mammalian holobiont: bank voles selected for herbivorous capability evolved distinct and robust gut bacterial communities
Abstract. According to the “hologenome” theory of evolution natural selection and evolution can act through a conglomerate biological unit, the “holobiont”
https://academic.oup.com/ismecommun/advance-article/doi/10.1093/ismeco/ycaf160/8251380
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Mateusz Konczal
bioRxiv Evolutionary Biology
4 months ago
Interplay between purging and admixture shapes genetic load in an invasive guppy population
https://www.biorxiv.org/content/10.1101/2025.09.12.675788v1
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Our latest preprint shows that in translocated invasive guppy population, genetic load is reshaped by purging and admixture. A bottleneck purged strongly deleterious mutations, but admixture reversed this effect while reducing the load of weakly deleterious mutations.
www.biorxiv.org/content/10.1...
loading . . .
Interplay between purging and admixture shapes genetic load in an invasive guppy population
Demographic history can shape the genetic load of populations by influencing the efficacy of selection, levels of heterozygosity, and by incorporation of new variants via gene flow. Understanding thes...
https://www.biorxiv.org/content/10.1101/2025.09.12.675788v1
4 months ago
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Mateusz Konczal
Marianna Karageorgi
4 months ago
How do populations maintain an evolutionary memory? I am happy to share that our work with Dmitri Petrov
@petrovadmitri.bsky.social
, Paul Schmidt, and colleagues on dominance reversal and stabilization of insecticide resistance in changing environments over time is now published at Nature EE.
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Beneficial reversal of dominance maintains a large-effect resistance polymorphism under fluctuating insecticide selection - Nature Ecology & Evolution
Measuring selection and dominance in fitness of the insecticide-resistant Ace alleles in Drosophila melanogaster, the authors show evidence for beneficial reversal of dominance, a mechanism that can s...
https://www.nature.com/articles/s41559-025-02853-x
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Mateusz Konczal
bioRxiv Evolutionary Biology
4 months ago
Fighting to persist: Genetic rescue increases long-term fitness despite elevated genetic load
https://www.biorxiv.org/content/10.1101/2025.09.06.673525v1
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Check out our latest work! We experimentally showed that
#genetic
#rescue
works: in the bulb mites, boosting genome-wide variation improved survival for 20 generations in high temp. Elevated genetic load or sexually selected traits? Barely mattered.
#Conservation
www.biorxiv.org/content/10.1...
4 months ago
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Mateusz Konczal
Evolutionary Biology Group, Adam Mickiewicz University
4 months ago
@neelamporwal.bsky.social
‘s talk about estimating extinction risks under sexual selection using simulations, at PEC2025 won the first prize for the best student talk. So, should animals swipe right for survival?🐧
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Fausto Rodríguez Zapata
4 months ago
Enhancing local meiotic crossovers in Arabidopsis and maize through juxtaposition of heterozygous and homozygous regions | Nature Plants
share.google/ZsqLLUu9l2Zv...
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Enhancing local meiotic crossovers in Arabidopsis and maize through juxtaposition of heterozygous and homozygous regions - Nature Plants
This study discovered that locally confined DNA differences boost crossover rates in both Arabidopsis and maize, revealing a conserved mechanism that can accelerate plant breeding and trait introgress...
https://share.google/ZsqLLUu9l2ZvoKo4j
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Mateusz Konczal
Rayan Chikhi
4 months ago
🌎👩🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.
doi.org/10.1101/2024...
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Clàudia Fontserè
4 months ago
This is now published at
#MolecularEcology
onlinelibrary.wiley.com/doi/10.1111/...
Check it out!
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Katerina Guschanski
4 months ago
Fantastic dental calculus and where to find it Johnny Richards and team (
@markella-morait.bsky.social
+ curators from 5 museums) survey >140 mammalian species with >1,600 specimens to understand what factors determine dental calculus formation.
#aDNA
#museomics
www.biorxiv.org/content/10.1...
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Jacek Radwan
5 months ago
If you are frustrated with the quality of reviews and excessive article processing charges, take a minute read:
trulyopenscience.blogspot.com/2025/07/a-si...
We researchers really have a power to change this!
#ScientificPublishing
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A simple recipe for a truly open, prestigious, society-owned journal
Is there anything wrong with the current model of scientific publishing, and, if so, can we, practising researchers, do anything about it? I...
https://trulyopenscience.blogspot.com/2025/07/a-simple-recipe-for-truly-open.html
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Mateusz Konczal
Erik Postma
4 months ago
With
#eseb2025
coming to a close, it is time to start making plans for 2026. Interested in the interface of evolution 🧬 and ecology 🌳? Come to our
#ExE
conference hosted by
@uniexecec.bsky.social
in beautiful
#Cornwall
. Leave your email address at
tinyurl.com/EvolxEcol
to join our mailing list!
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Small update: Plenaries and Nosil talks: "Nature/Science" in the bottom right of a slide
#eseb2025
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4 months ago
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Mateusz Konczal
Evolutionary Biology Group, Adam Mickiewicz University
4 months ago
We are having fantastic time presenting and discussing our work at
#ESEB2025
- Neelam Porwal answered a question "How sexual selection shapes small populations demography under recurrent heatwaves"
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#eseb2025
talks were great so far. Subjective ranking of the most common quotes: - theory and modeling: "with this very simple approach" - genomics: "using methodology you all know" - plenaries: "Nature/Science" in the bottom right of a slide - posters: "una cerveza por favor"
4 months ago
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Molecular Biology and Evolution
8 months ago
Stuart et al. show footprints of selection after near-extinction: genetics of wild and captive Lord Howe stick insect show that after a severe bottleneck, inbreeding appears to remove harmful mutations via increased homozygosity. 🔗
doi.org/10.1093/molb...
#selection
#evobio
#molbio
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Purging of Highly Deleterious Mutations Through an Extreme Bottleneck
Abstract. Transitions to captivity often produce population bottlenecks. On the one hand, bottlenecks increase inbreeding and decrease effective population
https://doi.org/10.1093/molbev/msaf079
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"Dissertationibus conscriptis et publice defensis." What a day it was! Congratulations
@k-burda.bsky.social
So proud of you
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9 months ago
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Here we come! A shiny profile of our group is on. Exciting news are coming soon
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9 months ago
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Mateusz Konczal
Chris Jiggins
9 months ago
Excited about these new results on a butterfly-plant arms race where one butterfly has overcome a physical plant defence - hooked trichomes- with a combination of external and internal adaptations. Well done
@ritabrata1907.bsky.social
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Mateusz Konczal
Nicolas Dussex
10 months ago
I am looking for a Postdoc (3 years, start Mid-2025) to work on conservation genomics of ringed seal in the Baltic. The project will use genomic data for 100s of individuals, SDM and genomic simulations.
#conservationgenetics
#consgen
Apply here:
recruit.visma.com/spa/public/a...
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Hidden gems
#Bialowieza
#wisent
#skull
10 months ago
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Mateusz Konczal
Molly Przeworski
11 months ago
“The distribution of highly deleterious variants across human ancestry groups”. Preprint with Anastasia Stolyarova and
@gcbias.bsky.social
:
www.biorxiv.org/content/10.1...
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The distribution of highly deleterious variants across human ancestry groups
A major focus of human genetics is to map severe disease mutations. Increasingly that goal is understood as requiring huge numbers of people to be sequenced from every broadly-defined genetic ancestry...
https://www.biorxiv.org/content/10.1101/2025.01.31.635988v1
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Every third de novo mutation is lost immediately after appearance, irrespective of population size: (1 - 1/2N)^2N ~ e^-(2N/2N) ~ 0.368
11 months ago
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"The evolutionary ecology of ethanol" - I don't know, but sounds somehow intriguing
www.cell.com/trends/ecolo...
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The evolutionary ecology of ethanol
The consumption of ethanol has frequently been seen as largely restricted to humans. Here, we take a broad eco-evolutionary approach to understanding ethanol’s potential impact on the natural world. There is growing evidence that ethanol is present in many wild fruits, saps, and nectars and that ethanol ingestion offers benefits that favour adaptations for its use in multiple taxa. Explanations for ethanol consumption span both the nutritional and non-nutritional, with potential medicinal value or cognitive effects (with social–behavioural benefits) explored. We conclude that ethanol is ecologically relevant and that it has shaped the evolution of many species and structured symbiotic relationships among organisms, including plants, yeast, bacteria, insects, and mammals.
https://www.cell.com/trends/ecology-evolution/fulltext/S0169-5347(24)00240-4
12 months ago
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Graham Coop
12 months ago
Congrats to
@jeffgroh.bsky.social
et al on publication of "Ancient structural variants control sex-specific flowering time morphs in walnuts and hickories"
www.science.org/doi/10.1126/...
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Mateusz Konczal
about 1 year ago
Join us for the 1st Holocentric Chromosomes conference! If you work on holocentric plants🌱, arthropods🦋or worms🪱, cell biology or macroevolution🧬, this conference is for you! Amazing keynotes!
@joanameier.bsky.social
@amarques.bsky.social
, Marcial Escudero and Ines Drinnenberg @UniNeuchatel
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Alex Mackintosh
about 1 year ago
My and Derek Setter's work on gene flow is now published in the latest issue of Genetics. We show that it is possible to detect past gene flow between two populations by summarising the asymmetry in pop-specific external branch lengths. 1/2
tinyurl.com/5ff8ch9e
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Genealogical asymmetry under the isolation with migration model and a two-taxon test for gene flow
Abstract. Methods for detecting gene flow between populations often rely on asymmetry in the average length of particular genealogical branches, with the A
https://tinyurl.com/5ff8ch9e
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Krystyna Nadachowska-Brzyska
about 1 year ago
I am looking for a postdoc! Pls share
#postdoc
#genomics
#insects
#inversions
genomicsofoutbreaks.com/?page_id=141
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Jeffrey Ross-Ibarra
about 1 year ago
Just your regular reminder how awesome this review on inbreeding depression is.
www.nature.com/articles/nrg...
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The genetics of inbreeding depression - Nature Reviews Genetics
The genetic basis of inbreeding depression and of the related phenomenon, heterosis, has been a puzzle for many decades. Based on recent studies in many species, the authors argue that both phenomena ...
https://www.nature.com/articles/nrg2664
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Krystyna Nadachowska-Brzyska
about 1 year ago
Finally! It was a LOT of work :) Kudos to the team. See how crazy inversion polymorphism can be.
#inversions
#BarkBeetles
Complex genomic landscape of inversion polymorphism in Europe's most destructive forest pest
academic.oup.com/gbe/article/...
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Complex genomic landscape of inversion polymorphism in Europe's most destructive forest pest
Abstract. In many species, polymorphic genomic inversions underlie complex phenotypic polymorphisms and facilitate local adaptation in the face of gene flo
https://academic.oup.com/gbe/article/doi/10.1093/gbe/evae263/7916417
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Mateusz Konczal
Natalia Jagielska (娜塔莉)
about 1 year ago
This is not a model. Or a shabby taxidermized modern rhino. This is a "fossilised" Woolly Rhinoceros, discovered in Starunia mine in Carpathian Ukraine (then Poland) in 1929. Dating to the Pleistocene, its exquisite preservation is owed to a mixture of brine, oil & clay. Held on display in Krakow. 🧵
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Katerina Guschanski
about 1 year ago
If you like genomics, speciation, and primates, this PhD position is for you! Unraveling the genomic architecture of speciation and gene flow in a crazy group of monkeys at U of Edinburgh . Do reach out with questions!
evol.mcmaster.ca/brian/evoldi...
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My favorite example of exaptation (or co-option) are venom proteins independently co-opted from non-toxic homologous in snakes, lizards and platypus. Source:
www.nature.com/articles/nat...
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about 1 year ago
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Greg Owens
about 1 year ago
Our lab is reading Hoffman et al this week in lab meeting. They look at inbreeding depression after an extreme bottleneck in northern elephant seals. 1/
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Genomic and fitness consequences of a near-extinction event in the northern elephant seal - Nature Ecology & Evolution
Analysis of northern elephant seal populations shows no evidence of inbreeding depression, probably because a recent extreme bottleneck purged much of the genetic load.
https://www.nature.com/articles/s41559-024-02533-2
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Mateusz Konczal
Narodowe Centrum Nauki
about 1 year ago
How did dinosaurs conquer the world? Polish scientists help explain it, with research funded by
#NCN
.
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Mateusz Konczal
Jess da Silva
about 1 year ago
Check out this new paper just out in Trends in Ecology & Evolution on better understanding genetic extinction debt for conservation.
doi.org/10.1016/j.tr...
#conservationgenetics
#PopulationGenetics
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Redirecting
https://doi.org/10.1016/j.tree.2024.10.008
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Mateusz Konczal
Genetics Society UK
about 1 year ago
Congratulations to Prof. Josephine Pemberton on being awarded the prestigious Genetics Society Medal! 🏅 Her groundbreaking contributions to genetics, from understanding natural populations to evolutionary biology, continue to inspire us all.
genetics.org.uk/medals-and-p...
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