Have you ever looked at a protein structure and wondered... What am I even looking at? To help navigate, I wrote a PyMOL plugin that automatically identifies and labels protein chains. It leverages the 𝗦𝗜𝗙𝗧𝗦 𝗺𝗮𝗽𝗽𝗶𝗻𝗴 (from UniProt and PDBe) to colour and label protein chains by their UniProt IDs.

This work is now officially published @natsmb.nature.com with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...

And it's now live in Nature Structural & Molecular Biology! Many thanks to James and @lapassmore.bsky.social for a great collaboration. www.nature.com/articles/s41...

A very late repost: Mad2 is an incredible metamorphic protein capable of adopting multiple conformations. Here we reviewed existing structural data and investigated this ever-changing protein using a combination of real-time NMR and MD simulations (kudos to Joe! @jgreener64.bsky.social)

🚨 New from PDBe! Check out the revamped PDBeChem service with enhanced Ligand Pages! 🔍 Explore detailed ligand data, interaction stats, bound structures, related ligands, and more—all in one place. 👉 Read more in the news: https://buff.ly/4g8eF6E

Happy to announce that the latest UniProt NAR paper is now out. Find out what we've been up to here academic.oup.com/nar/advance-...

In this work, James used NMR with @connyyu.bsky.social , crosslinking mass spec with the Rappsilber lab and biochemical reconstitution to discover that dispersed regions within the IDRs interact with multiple conserved binding sites on Ccr4-Not.

"You cannot by sheer force compel scientific truths to reveal themselves. The major insights come only to the individuals who have the patience to develop an intimate understanding of a problem, who have the space and the freedom to take professional risks and explore apparently bizarre ideas...