I am excited to announce our paper “Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis” is out in Cell Reports! @eaphelps.bsky.social www.cell.com/cell-reports...

Join us for the 2025 Rachmiel Levine-Arthur Riggs Diabetes Research Symposium. We have an amazing program this year focusing on type 1 #diabetes. We have also extended the abstract submission deadline to Sept 19. Register and submit your abstract a www.levinesymposium.com

It was great fun to write this review with friends and colleagues Melkam Kebede, Belinda Yau, @jinghughes.bsky.social and Julien Ghislain

Simultaneous in vivo calcium imaging of up to 100 islets coupled with CGM measurements in lean and ob/ob mice—this is impressive! www.biorxiv.org/content/10.1...

Out today in @jclinical-invest.bsky.social! We discovered a novel regulator of adaptive beta cell proliferation, the protein deacetylase SIRT2, that acts through a metabolic mechanism. Bluetorial below (1/5). tinyurl.com/ydvv9u2s

With credit to @huisinglab.bsky.social for inspiring the tradition, today we bid farewell to our very first lab member Sean Lee who is joining the Cell Biology, Stem Cells, and Development PhD program here at @cuanschutz.bsky.social‬. Best of luck Sean, we expect great things from you!

These are two important papers that profile beta cell excitotoxicity in response to a sulfonylurea or the VDAC1-stabilizing molecule SW016789. Comparing these studies should make for an excellent journal club. Congrats to all authors! @kalwat.bsky.social tinyurl.com/fwrzrtk9 tinyurl.com/3nzfsp79

Review on metabolism in stem cell derived beta cells from former PhD student with us, Frank Lin. Cell Reports @cp-cellreports.bsky.social www.sciencedirect.com/science/arti...

How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/

Very excited to share new work on the origins of beta cell senescence in #T1D led by talented PhD student Jasmine Pipella! 🥂🎉 online today! diabetesjournals.org/diabetes/art...

Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S. “Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.” Read the article here. No subscription required: www.nytimes.com/2025/06/03/u...

Actin remodeling in beta cells adds new layers of upstream regulation - Congrats! @ronnyhelman.bsky.social

Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this! www.biorxiv.org/content/10.1...

Check out my talk this afternoon where I’ll share our latest work! #isletbiology #metabolism #IMM The University of Texas Health Science Center at Houston (UTHealth Houston)

Our lab website www.worthamlab.org is now live! By the way, we are recruiting at all levels. If our work interests you, consider joining us for cutting edge research in a collegial environment at University of Colorado Anschutz. Not to mention that Denver is a great place to live.

A fungus (Candida dubliniensis) macrophage axis in neonatal mice is required for optimal beta cell development and function throughout the lifespan with the fungus also exerting beta cell regenerative properties in experimental models of #diabetes @science.org www.science.org/doi/10.1126/...

Functional #insulin secretory defects occur in the remaining mass of beta cells during human #T1D pathogenesis not strictly correlated with the extent of insulitis #islets www.biorxiv.org/content/10.1...

Abstracts for #METPHYS2025 are due this Friday! There are multiple short talks available! FEB28 is also the deadline for the Vanderbilt Vibrant program This initiative will provide several awards of $2000 to help new investigators attend www.sablesys.com/metphys2025-...

We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction. https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1

Excited to share our publication in @cp-iscience.bsky.social Islet single-cell transcriptomic profiling during obesity-induced beta cell expansion in female mice #IMM @uthealthhouston.bsky.social @bcmhouston.bsky.social 🧵 www.cell.com/iscience/ful...

Cutting NIH funds hurts all Americans. Why? Three main reasons: #1: These funds support a huge industry in all states. For every $1 of NIH funding generated, there is a short-term return of ~$2.46 in economic activity. $4B in cuts will take away $10B from the economy.

Looking forward to discussing this technique for single cell spatially resolved metabolic tracing in BDC journal club today at 10AM MT—don’t miss it! www.nature.com/articles/s42...

Looking forward to journal club tomorrow where we will discuss this fantastic paper from Zong Wei's lab describing how diet-induced obesity impacts enhancer-associated histone modifications in islets www.nature.com/articles/s41...

Cool paper, congrats! Beta cells do not tolerate intermittent fasting (24h every third day) during adolescence, which contrasts with beneficial effects in old mice. Might there be a very high sensitivity of beta cells to altered feeding rhythms during a late stage of functional maturation?

What a pleasant surprise for our recent paper by Dr. Jessica Huang to feature in the 'Year in Review' issue of Nature Reviews Endocrinology - courtesy of Prof. Carmela Evans-Molina. ;-) doi.org/10.1038/s415...

A comprehensive and much-needed assessment of donor/islet features (and potential confounders) associated with hormone secretion by isolated human islets. Delta cell abundance is anti-correlated with several aspects of beta cell function and seemingly influenced by T2D genetic risk score (!)

The only thing I am missing here is Epigenetic Hulk account.

go.bsky.app/3wdSpdi It can be difficult to recreate your following list here, please comment/tag any other islet/panc people I am missing and I will edit the pack.