Happy to announce new work by Postdoc Fellow Yu-Sheng Yeh & @razanilab.bsky.social showing natural sugar #trehalose (known #autophagy #TFEB inducer) improves #obesity #metabolism. Caveat: it is ineffective by oral route & KO of gut enzyme #trehalase doesn't help. www.frontiersin.org/journals/nut...

Great showing by @razanilab.bsky.social at #VascularDiscovery25 in Baltimore the past 3 days. Kudos to efforts of Dr. Kathleen Martin, the entire organizing committee, & @americanheart.bsky.social for the excellent programming & opportunity to present our work. See you all next year in Bellevue, WA!

Spilling the skinny on fat cells! @razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/UPFJ5sO

Spilling the skinny on fat cells! ASCI member @razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/Wc9YdnR

Nice work in @cp-immunity.bsky.social by Cobo & Glass labs showing #macrophage crystalline/particle uptake universally induce #lysosome #transcription program via #AMPK #TFEB independent of #inflammation pathways. Thx for including @razanilab.bsky.social in the journey. www.cell.com/immunity/abs...

Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year Razani lab effort in @jclinical-invest.bsky.social by postdoc maven Yu-Sheng Yeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL) jci.org/articles/view/185340

Announcing #Pittsburgh Metabolism Consortium. Joint venture by the Endocrinology Division, Center for Immunometabolism (CIM), Center for Mitochondrial Medicine (C3M), we aim to bring together the #metabolism community at the University of Pittsburgh. Spring seminar series start next week 🤩

Fresh off the press data (for FY24) on the immense economic impact of #NIH #biomedical #science research. $2.56 goes into economy for every $1 grant funding. 💪 www.unitedformedicalresearch.org/annual-econo...

Excellent #immunometabolism concept presented by Garaude lab @univbordeaux.bsky.social in @nature.com. #macrophage #nutrient use of dead bacteria via #phagocysosis drives distinct #metabolism pathways. #mTOR rears its head of course. #efferocytosis should be up next! www.nature.com/articles/s41...

Is dietary #protein and #mTOR good for skeletal muscle health or not? At least for #sarcopenia in elderly it is paradoxically harmful and enhancing #BCAA catabolism is protective. Interesting work in @natureaging.bsky.social by lab of Prof. Tao Li @ Sichuan University. www.nature.com/articles/s43...

Hello everyone, greetings from members of the Razani laboratory. First post for us here. We heard many #physicians, #scientists, and #entrepreneurs also started a presence here and so we wanted to join the fun and learn from you all!