Bacterial cell widening alters periplasmic size and activates envelope stress responses Kerwyn Huang, @typaslab.bsky.social et al find that E. coli outer-membrane protein RcsF senses reduced periplasm thickness due to increased cell width, & activates Rcs signaling www.embopress.org/doi/full/10....

Thrilled to see my first publication on food chain biofilms out! Check out the super cool biofilms Pseudomonas makes on food surfaces and the contribution of these to food spoilage. We're continuing to work in this space to find novel ways to extend food shelf life and reduce food waste! 🧫🧪

Great news - this work is now published!! Big congrats to @yeowjiang.bsky.social - amazing that he mastered cryo-EM and now solved his 2nd set of strs! And kudos to Chee Geng (& Nadege) for non-trivial homogeneous purification of TolQRA! pubs.acs.org/doi/10.1021/... #MicroSky #SGBUG 1/4

@weeboont.bsky.social talked about our lab's recent preprint where we report AsmA superfamily proteins, believed to be phospholipid transporters, localizing to cell poles in E. coli. Really interesting observations, with impt implications for OM assembly! Read it 👇! www.biorxiv.org/content/10.1...

Lipid interactions are important for the Tol-Pal complex in maintaining outer membrane lipid homeostasis https://www.biorxiv.org/content/10.1101/2025.06.10.658765v1

Our new paper on FtsN is out! Now there are three tracks for organized cell wall constriction-- the old, boring E. coli always manages to surprise us. A special shout-out to all the people who made this work possible, especially Dr. Jason Lyu, and Dr. David Weiss. www.nature.com/articles/s41...

Our latest work on the bacterial Tol-Pal complex now published! Kudos & congrats to the brilliant @weeboont.bsky.social! We can (finally) confidently assign the true function of Tol-Pal in maintaining OM lipid homeostasis, independent of cell division! 👇 1/7 #microsky www.nature.com/articles/s41...

My lab at SCELSE, NTU, Singapore, is recruiting a PhD student to study food chain biofilms! The PhD will commence in January 2026 and tuition and stipend is provided for 4 years. Singaporean and international applicants welcome. See attached for more details. Please share widely!

Really excited to be sharing our newest work on the bacterial Tol-Pal complex! The amazing Jiang YEOW solved cryo-EM structures of the TolQRA complex in 2 rotary states, aiding us to come up with a model for force transduction across the cell envelope! Pls RT! #SGBUG #SCELSE_SG #ChemNUS