ScienceAdviser: Update the textbooks: There’s another way to make DNA | Science | AAAS www.science.org/content/arti... "a team described a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide"

"A surplus of collective intelligence has pushed us to the current state of knowledge.." @pholme.bsky.social petterhol.me/2026/03/20/s...

"What if we did not assume that Asia was just a residual category, a variant of 'not-Europe', but saw it as a space of with its own particular history and sociopolitical dynamics, not defined only by encounters with European colonialism?" @aysezarakol.bsky.social

Computational design of conformation-biasing mutations to alter protein functions | Science www.science.org/doi/10.1126/...

Happy Pi Day! Around 1,600 years ago, the Chinese geometer Zu Chongzhi pondered polygons having 24,576 sides to squeeze pi out to 3.1415926 < π < 3.1415927. By allowing the number of sides in the polygons to increase indefinitely, we can generate as many digits of pi as we like. @stevenstrogatz.com

The perspective looks all wrong. You're staring straight at this barmaid, but her reflection in the mirror is way off to right. Even worse, her reflection is facing a guy who doesn't appear in the main view! But in 2000, a researcher showed this perspective is actually possible! (1/n)

Kadın varsa, umut var! Jin hebe hevi ji heye! Where there is a woman, there is also hope!

www.nature.com/articles/s41... "...papers and patents are increasingly less likely to break with the past in ways that push science and technology in new directions. This pattern holds universally across fields and is robust across multiple different citation- and text-based metrics."

AI tools boost individual scientists but could limit research as a whole www.nature.com/articles/d41...

www.quantamagazine.org/a-new-comple... "If I had access to an infinitely powerful classical oracle, could I use it to efficiently perform any quantum state transformation of my choice?" "We found that one problem just showed up again and again in many different places." @henryyuen.bsky.social

15 years ago today I arrived on Downing Street in a cage. I've seen off Cameron, May, Johnson, Truss and Sunak and I'm still going strong. Only two Prime Ministers have ever done longer stints here: William Pitt the Younger and Sir Robert Walpole. Bill and Bob - I'm coming for you... (Photos AP)

Deep learning–guided design of dynamic proteins | Science www.science.org/doi/10.1126/...

I look forward to reading Azimuth, johncarlosbaez.wordpress.com, every Monday morning. Here is what I learned there this morning: William Clifford, On the space-theory of matter, Proceedings of the Cambridge Philosophical Society 2 (1876), 157–158.

www.denizcemonduygu.com/philo/browse/ @dencemond.bsky.social

serbestiyet.com/yazarlar/emo... Bu yazının içinde hiç nokta [.] görmeyeceksiniz. Hrant Dink ve Tahir Elçi iki güzel arayüzdü. 24 yüzyıl boyunca bütün diller için cümlelerin arayüzü olan nokta, bu iki kıymetli arayüz kaybolunca, ortaya çıkan boşluğa düştü. Cümlelerimin sonunda hepimizin boşluğu var.

I was wondering whether AI will mostly benefit those in the middle and help flatten the distribution (Autor, D.H. and D. Dorn, American Economic Review, 103(5), 2013), or whether it will instead sharpen the tails. What do you think?

Teaching nanostructures to build themselves physicstoday.aip.org/features/tea...

"Mazrui called for a university true to its classical vision, as the home of the scholar fascinated by ideas; Rodney saw the university as the home of the public intellectual, a committed intellectual located in her time/place, and deeply engaged with the wider society" www.gbpssi.in/admin/course...

🚨New paper! The “partial causality decomposition” When many things influence an outcome, how to distinguish individual vs collective #causality? A framework to disentangle these complex relationships into synergistic, redundant, and unique components: arxiv.org/abs/2501.11447 🧵

www.theguardian.com/football/liv... You may find following this more enjoyable than watching the game; doing both could make you miss some sentences/videos. 😇 @danielharris.bsky.social

Had fun presenting at @kempnerinstitute.bsky.social on Theories of rapid learning, creativity, and reasoning: of mice and machines. Video: www.youtube.com/watch?v=jLmK... Papers: Learning: www.nature.com/articles/s41... Creativity: arxiv.org/abs/2412.20292 Math Reasoning: arxiv.org/abs/2502.07154

Excited to finally share this work w/ @suryaganguli.bsky.social Tl;dr: we find the first closed-form analytical theory that replicates the outputs of the very simplest diffusion models, with median pixel wise r^2 values of 90%+. arxiv.org/abs/2412.20292

As a neurologist, I see the term "dopamine" everywhere: dopamine fasting, dopamine hits, dopamine culture. It's become a cultural shorthand for pleasure. But the real story is far more complex and fascinating. Here’s a thread on what we actually know 🧠

www.quantamagazine.org/researchers-... "For the first time, researchers have shown how the creativity of diffusion models can be thought of as a by-product of the denoising process itself, one that can be formalized mathematically and predicted with an unprecedentedly high degree of accuracy."

Mamdani Did All the Things the Establishment Hates. He Won Anyway. newrepublic.com/article/1972... via @newrepublic.com

@senemaydndzgit.bsky.social argues that "regional international crises in the form of regional geopolitical conflicts present competitive authoritarian regimes with multiple opportunities to boost regime security which is 'a process of constraining internal and external challengers'."

doi.org/10.1038/3121... "The time span of human memory is often a matter of years, yet it is believed that almost all the molecules in our bodies turnover in days or weeks. How then is memory stored in the brain so that its trace is relatively immune to molecular turnover?" |FHC Crick, Nature, 1984

www.quantamagazine.org/the-strange-... "Perhaps statistical physics, which provided the first tools for understanding collective behavior, will be the key not just to using but also to understanding the inscrutable machine intelligences changing our world." @elisecutts.bsky.social

Good read: Inside arXiv - the Most Transformative Platform in All of Science www.wired.com/story/inside...

Çocuklara rastgele yürüme anlatıcam. Bozuk para yok, hani yazı gelince şöyle, tura gelince böyle filan. Bu arada niçin hep yazı mı, tura mı diye soruyoruz da, turayı öne almıyoruz? Rastgele bir şey anlatıcam, başlangıcım öyle değil. Hapisteki 299 genci güldürmek mümkün mü?

www.youtube.com/watch?v=hz2S... "Another thing I must point out is that you cannot prove a vague theory wrong.[…] Also, if the process of computing the consequences is indefinite, then with a little skill any experimental result can be made to look like the expected consequences." | R Feynman, 1964

"Ancak tarihin kritik bir anında, pek çok faktörün denk gelmesiyle ve doğru adımların uygun bir dizi oluşturmasıyla, en beklenmedik zamanlarda umut ortaya çıkabilir. Türkiye, küresel dalgadan ayrışabilir. Kötü örnek olmaktan çıkıp, imrenilecek bir deneyim üretebilir." @yahyakemalcan.bsky.social

culturaltutor.substack.com/p/areopagus-... Claudio Monteverdi (1567-1643) operanın ilk büyük öncüsü. "Si dolce e'l tormento (ne tatlıdır bu azap)" hemen ilk tıklayabileceğiniz yerde. "Yaşama biçimimiz ve alışkanlıklarımız değişmiş olsa da, biz hâlâ o zaman kimsek, oyuz" der @areopagus.bsky.social

"Before Noether’s theorem, the principle of conservation of energy was shrouded in mystery," the physicist and mathematician Feza Gürsey wrote in 1983. "… Noether’s simple and profound mathematical formulation did much to demystify physics." www.quantamagazine.org/how-noethers...

"...bitince kurtulacak mıydık geçince unutacak/ sürekliliğin fısıltısı duyulmuyordu." | @asumansusam.bsky.social

19.yy başındaki İngiltere'de "computer," bir makinenin değil, genellikle kadın olan bir büro memurunun adıydı; bunlar, hükümet, Astronomi Derneği veya Deniz Kuvvetleri için elle sıkıcı hesaplamalar yapmak zorundaydılar. | The Eye of the Master, 2. Bölüm | Matteo Pasquinelli

"...the inner code of AI is constituted not by the imitation of biological intelligence but by the intelligence of labour and social relations." The Eye of the Master: A Social History of Artificial Intelligence | Matteo Pasquinelli

Excited to share that AI Snake Oil is one of Nature's 10 best books of 2024! www.nature.com/articles/d41... The whole first chapter is available online: press.princeton.edu/books/hardco... We hope you find it useful.

This is how AI SNAKE OIL begins: "Imagine an alternate universe in which people don’t have words for different forms of transportation—only the collective noun vehicle.” @randomwalker.bsky.social @sayash.bsky.social You immediately anticipate what will replace the vehicle and rush into what follows.

Ankara'da oturmayanlar için: birartibir.org/kisisel-zama... ve birartibir.org/oznel-zaman-...

If you are up for a challenge, check out the open problem collection at peterkagey.com/open-problem... by Peter Kagey peterkagey.com

Bir çocuğun aklından zaman ve uzam (içinde yılbaşı da geciyor)... serbestiyet.com/yazarlar/dol...

"Jimmy Carter, who died today at the age of 100, wrote the following, and placed it in Voyager 1:" @rbreich.bsky.social (for Reich's "in memoriam" robertreich.substack.com/p/sunday-cap...)

Endüstrideki şirketlerde çalışan arkadaşlar, eski öğrencilerimle muhabbet ediyoruz. Bilindik şikayetler, dertler dışında hep bir umuttan söz ediyorum. Nasıl umutlu olabildiğimi soruyorlar. Siz diyorum "kurumsal yaşıyorsunuz, bense kuramsal." Nasıl, eh, gülüyorlar tabii, ama geçmeseler keşke.

serbestiyet.com/yazarlar/kah... ...Javier’in yerine hikayenin anlatıcısı gelirken; bir minibüs şoförü duraklardan birinden alındığında, müşterilerin içinden 20 yıllık bir veznedar minibüsü kullanmaya başlıyordu...bir öğretmen uzaklaştırıldığında,...çicekçilik yapan veli, öğretmenliği üstleniyordu.

Ne zaman dolmuşta önde otursam, bir derneğin saymanı olmuş gibi heyecanlanıyorum. Bütün toplanan para elimden geçiyor, kolay mı?

Bu sabah 08.40 dersimden hemen önce çaldım gençler heyecanlansın diye. İyi oldu; ben bayağı heyecanlandım. www.youtube.com/watch?v=dOZF... Shostakovich composed this Concertino for 2 pianos in Dec '53 for his son Maxim, who premiered it with Alla Maloletkova on Nov 8 '54 at the Moscow Conservatory

"Zevkler incelmiş, iyi de ben dümdüzüm." birikimdergisi.com/haftalik/119...

"Peering down the [supply] chain now reveals not only astonishing technological progress but also environmental degradation, hazardous working conditions, and questionable economic policies." www.wheaton.edu/academics/fa... hedgehogreview.com/issues/in-ne...