Enhancing NLR activation by endophytes carrying recognized effectors that are expressed in the presence of ROS. #plantimmunity www.cell.com/cell-host-mi...

The work is led by @weiweibio.bsky.social, a talented postdoc looking for faculty positions now and conceptualized both computational prediction and in lab validation. Computational implementation is a collaboration with Xing Wu, postdoc with @mexpositoalonso.bsky.social Qs - contact us 💻🌱🧬

Just wrapped up the EMBO Integrative Modeling Course, beautifully organized by @ezgikaraca.bsky.social & her amazing team with care🩵! From protein docking & AI-based modeling to endless coffee breaks,seaside dinners, and karaoke, it was science + community at its best. Truly unforgettable @embo.org

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology: postdocs.stanford.edu/prospective/... #TeamMassSpec #Proteomics #GPCR #Postdoc

A year ago I gave my first chalk talk at the ZMPP symposium. This year, I returned for my 2nd symposium with a flash talk and poster presentation. Grateful for the chance to share my work, exchange ideas, and connect with colleagues—thanks @zmbp-tuebingen.bsky.social for making it so memorable!

Looking back at some of the inspiring lectures from #PPRM2025 in Edinburgh—such a privilege to learn from so many outstanding researchers. Grateful for this community and the ideas it sparks. @keikoutorii.bsky.social @gittacoaker.bsky.social @marischuster.bsky.social

Three inspiring days at #PPRM2025 in Edinburgh come to a close. From engaging talks to discussions, it’s been a privilege to share research and connect with this vibrant community. The John McIntyre Centre beneath Arthur’s Seat and even a touch of Scottish dance made the meeting truly unforgettable.

That’s a wrap for #PPRM2025. Great science, wonderful community and amazing location. Glad it all went smoothly and big thanks to @jackrhodes.bsky.social and @draegermarkus.bsky.social for helping organize the meeting.

Only a few more days left until the start of #PPRM2025. We have a fantastic line-up of speakers and the final program is now online. Check it out here: api.kdmeventsportal.co.uk/static/downl...

Full house for today’s @TheSainsburyLab seminar with Farid @Farid_El_Kasmi on #NLRbiology

Looking forward to joining the Plant Peptide Receptor Meeting (PPRM2025) this September in Edinburgh ..Excited for inspiring sessions and the opportunity to share my research with this vibrant community #PPRM2025

Delighted to have been selected for the EMBO Practical Course on Integrative Modelling of Biomolecular Interactions this September in Turkey! Looking forward to hands-on training in AI and computational structural biology and share my own research while connecting with inspiring researchers.

Discovery of NOT-GPCRs: An Archaeal Membrane Protein Family Whose AlphaFold Predictions Structurally Resemble G Protein-coupled Receptors jxiv.jst.go.jp/index.php/jx...

Nice containerization of AlphaFold, Boltz, and Chai, and calculation of metrics (including our ipSAE score for protein-protein interactions). www.biorxiv.org/content/10.1...

Fave study and paper… #EvolutionRocks #EVOMPMI #EffectorWisdom 👇🏾

We’re excited to share our latest work on plant pathogen effector protein evolution @biorxivpreprint.bsky.social. With @kamounlab.bsky.social and Abbas Maqbool. www.biorxiv.org/content/10.1...

🌱 From UC Davis: UC Davis scientists used AlphaFold to reengineer plant immune receptors, expanding bacterial detection and improving resistance to wilt pathogens. (Gitta Coaker) ▶️ www.ucdavis.edu/food/news/ho... #PlantScience #PlantBiology #PlantPathology

Abstract submission deadline for @pprm2025.bsky.social meeting in Edinburgh is the 1st of July, just a few more days before it closes. We have 35 slots available and are looking for new and exciting stories including those about technological advances. pprm2025.events.kdmeventsportal.co.uk

www.biorxiv.org/content/10.1... Up next at #2025ISMPMI @kseniakrasileva.bsky.social discussing work on protein language model for receptor engineering.

Great talk by Prof. Martin Stegmann at #ISMPMI2025 on CEP peptides in plant immunity. Brought back memories of TU Munich lab meetings—Jakub’s work shining on stage now. Congrats to him on wrapping up the PhD! 🌱🧬 #plantimmunity

Back from MPMI 2025 — what an amazing few days of science, ideas, and connections! Grateful for the chance to present my work and to meet in person some of the scientists I’ve long followed and learned from. Looking forward to crossing paths again! #PlantImmunity #ScienceCommunity #ISMPMI2025

Thrilled to share that Niels Gallas from ZMBP has won a Top Poster Prize at this year’s MPMI meeting! 👏 With hundreds of brilliant posters from around the world, it’s an incredible moment for @zmbp-tuebingen.bsky.social Big congratulations also to Nguyen from Tokyo University 👏 #ISMPMI2025

Thrilled to share our latest preprint! This work started during my PhD and was finished together with @jmadhuprakash.bsky.social. We found a Phytophthora infestans L-shaped effector that bridges a host TOL protein to activated NLRs to suppress immunity! www.biorxiv.org/content/10.1... 1/15

Up and ready! Find me at P-267 today for some molecular evolution and NLR biology! 🥬💻 You can also find the poster and preprint below 👇🏻 #2025ISMPMI

Building on this momentum! 👇 Exciting to see how ML tools like mamp-ml are enabling structure-free prediction of PRR-epitope interactions — the perfect complement to structure-guided NLR design. Rewiring plant immunity, one model at a time. #PlantImmunity #MachineLearning #PRRs #NLRs

@kseniakrasileva.bsky.social is the first talk at the engineering traits session at #2025ISMPMI Branching into PRRs thanks to @danimstevens.bsky.social. The ?: Can we use language models to predict host and microbe proteins interaction outcomes? The answer: Yes! New “mamp-ml”does pretty well.

Grateful to all that came to my poster at #2025ISMPMI this week 🌱 This was not an easy story to present, but the support and discussions were great and made this a journey worth telling!

What’s this intriguing complex? Together with Ben, we purified the AVRcap1b-SlNRC3 complex from our favourite plant—the Aussie wonder Nicotiana benthamiana aka benthi—and resolved this beautiful cryo-EM structure and see how AVRcap1b wraps around three SlNRC3 protomers! 4/10

Through its L-shaped structure, AVRcap1b sterically blocks the SlNRC3 resistosome by forming contacts with three protomers (half the hexameric resistosome)! 5/10

Remember TOL? How does it bind to AVRcap1b compared to SlNRC3? Turns out, they bind to opposite interfaces on AVRcap1b! This supports a dual-targeting mechanism, with the effector linking ‘immune suppression’ to ‘membrane trafficking’ 🧊 SlNRC3–AVRcap1b (cryoEM) 🧬 AVRcap1b–TOL (PDB:9RDC) 7/10

Our model: Once activated, dissociated NRC protomers assemble in a stepwise manner to form a full hexameric resistosome. AVRcap1b blocks this process, capturing NRC assembly intermediates and relocating them via the TOL-ESCRT pathway. Effector biology rocks! #EffectorWisdom 8/10

Long-awaited and worth every minute—Dr. Ksenia Krasileva (UC Berkeley) lit up the last day of #ISMPMI2025 with a deep dive into how AlphaFold, structure, and machine learning guide the design of new immune receptors. From diversity to design—can we outsmart pathogens? @kseniakrasileva.bsky.social

Super excited to be giving a talk at #2025ISMPMI today in the Synthetic biology concurrent session from 15:15 - 15:35! Come along if you’re interested in engineering Tandem Kinase Proteins

Stunning talk by Dr. Stella Cesari (PHIM, Univ. Montpellier): MAX effectors—structurally conserved but sequentially diverse. Beyond HIPPs, AVR-Pib hits MAPKKKs—key players in plant immunity. One fold, many targets? #ISMPMI2025 #MAXeffectors #MAPKKK #PlantImmunity @cbsmontpellier.bsky.social

Fascinating talk by Dr. Charles Roussin-Leveillée (Univ. of Lausanne): ETI stalls pathogens by drying the apoplast, not directly killing. Rehydration may restart infection—ReBORN in action? #ISMPMI2025 #ETI #ReBORN #PlantImmunity @charlesrleveillee.bsky.social

Fascinating talk by Dr. Talia Karasov (University of Utah) on how plant pathogens weaponize phage-derived tailocins to wipe out bacterial rivals. Microbes fighting microbes—nature’s own biotech. #ISMPMI2025 #Tailocins #MicrobialWarfare

New preprint! 📑@danimstevens.bsky.social led the development of mamp-ml, a machine learning protein language model approach to predict functional outcomes of immune receptor - microbial peptides interactions. mamp-ml performs better than AlphaFold2 I will talk about it Thr 10:10-10:30 #2025ISMPMI

Brilliant talk by Dr. Gitta Coaker (UC Davis) on engineering plant immunity via kinase-mediated recognition. Loved the insights on FLS2 tuning and tandem kinases like RWT4. Synthetic biology meets plant defense! 🌱 @mpmijournal.bsky.social @gittacoaker.bsky.social @kseniakrasileva.bsky.social

Protein engineering is a 🔥 theme at #2025ISMPMI @gittacoaker.bsky.social presents her lab’s research

Poster going up today at #ISMPMI2025! Exploring how BIR proteins bridge PTI & ETI via CSA1 & BAK1 🧬 📍 P-441 | 13:30–15:15 📄 Poster: doi.org/10.5281/zeno... #PlantImmunity #AlphaFold #OpenMPMI @mpmijournal.bsky.social @birgitkemmerling.bsky.social

A brilliant start to Plenary Session 2 at @mpmijournal.bsky.social Prof. Rosa Lozano-Durán delivered an outstanding talk highlighting just how cool and relevant plant virology truly is. Plant virology is not just relevant… it’s essential. @geminiteamlab.bsky.social

Incredibly inspiring talk about the discovery of the more than 200 immune systems in bacteria by Rotem Sorek. From computational discovery in 2018 through functional and structural analyses, even linking bacterial immune systems to that of eukaryotes. #2025ISMPMI

A vibrant first day at @mpmijournal.bsky.social Great science, great people, and great energy all around. Hung up my poster—presentation coming tomorrow! 🪧 P-441 | Mon 14 July | 13:30–15:15 PTI or ETI? Unveiling BIR evolution and functional diversity Excited for the days ahead. 🙌✨ #ISMPMI2025

Excited to present at @mpmijournal.bsky.social Can BIR proteins link PTI and ETI? Using AlphaFold & evolutionary insights, we dive into how BIRs balance immunity with CSA1 as a key regulator of cell death & receptor complex homeostasis. P-441 | Mon 14 July | 13:30–15:15 #2025ISMPMI