Nicolas Malaquin, PhD
@nmalaquin.bsky.social
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Scientist at the CRCHUM-Institut du Cancer de Montréal. Senescence SASP and cancer
@icsasenescence.bsky.social
#icsarome2025
. What a great meeting!! Thank you again for the organization, all the presentations and discussions!
about 2 months ago
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Félicitations à toute l’équipe!
add a skeleton here at some point
8 months ago
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reposted by
Nicolas Malaquin, PhD
Centre de recherche du CHUM
8 months ago
Apprenez-en davantage sur les travaux de recherche de Francis Rodier 👇
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Boosted by grant, Montreal research seeks to prevent dormant cancer cells from reawakening
Montreal researchers who are studying how ovarian cancer cells can reawaken after going dormant are ultimately trying to prevent cancer from coming back after treatment. The project, led by Dr. Franci...
https://montreal.citynews.ca/2025/03/19/montreal-research-dormant-cancer-cells/
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reposted by
Nicolas Malaquin, PhD
LBI Trauma
11 months ago
"Guidelines for minimal information on cellular senescence experimentation in vivo" The MICSE guidelines were initiated and coordinated by Mikolaj Ogrodnik, Heinz Redl, Nadja Ring (LBG SHoW), Johannes Grillari (LBI Trauma &
@bokuvienna.bsky.social
) & Marco Demaria (ICSA)
www.cell.com/cell/fulltex...
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Guidelines for minimal information on cellular senescence experimentation in vivo
This primer introduces the “minimal information on cellular senescence experimentation in vivo” (MICSE) guidelines, which aim to address the challenges in identifying and characterizing senescent cells. It provides an overview of senescence markers in various systems and offers a practical toolset to enhance our understanding of cellular senescence in vivo.
https://www.cell.com/cell/fulltext/S0092-8674(24)00640-8
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reposted by
Nicolas Malaquin, PhD
Nicolas Manel Lab
10 months ago
Showcasing this exciting paper from our good friends Fachinetti lab
@institutcurie.bsky.social
.
#Centromere
inactivation triggers
#senescence
: mis-segregated chromosomes deform the nuclear envelope and activate TORC2-ATR. We helped with
#cGAS
and some key suggestions.
doi.org/10.1038/s415...
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Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology
Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...
https://doi.org/10.1038/s41556-024-01565-x
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reposted by
Nicolas Malaquin, PhD
Hao Yin
10 months ago
Senescent cell identification SenCID
#MachineLearning
52 transcriptomic datasets; 30 cell types▶️6
#Senescence
modules Single-cell senescence trajectories in multi-tissue Aging & Diseases SMCs "have high basal senescence score"😬
@cp-cellmetabolism.bsky.social
2024
www.cell.com/cell-metabol...
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rdcu.be/d7Q3h
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Immune evasion through mitochondrial transfer in the tumour microenvironment
Nature - Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired...
https://rdcu.be/d7Q3h
10 months ago
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reposted by
Nicolas Malaquin, PhD
Centre de recherche du CHUM
10 months ago
À ÉCOUTER | Dans la dernière émission des Années Lumières sur Radio Canada, Francis Rodier, chercheur régulier au CRCHUM s’exprime sur la radiothérapie, ses différents mécanismes et ses nouveautés. Pour en savoir plus :
bit.ly/4apwuMW
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Radiothérapie : des mécanismes secrets régulent son efficacité
Les années lumière | Ça fait plus de 70 ans qu’on utilise la radiothérapie pour traiter des tumeurs cancéreuses. Malgré tout, la méthode conserve encore certains mystères. Des scientifiques australien...
https://bit.ly/4apwuMW
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