The most anticipated RCT in ID 🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia N:1341 Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia Cefazolin is non-inferior (90d mortality)& less AKI than ASPs A practice-changer RCT that must change the guidelines #ESCMIDGlobal #IDSky

We need facts as never before. 3 years after Putin invaded Ukraine, I spent 24 hours with combat medics on the Ukrainian frontline. Their courage, compassion, dedication & skill are astounding. Please read & please never stop standing up for Ukraine. 🇺🇦 www.theguardian.com/world/2025/f...

More than half of the Gm-negative infections in soldiers in the Ukraine conflict are resistant to carbapenems - fascinating presentation on #AMR in conflict settings from @catanita.bsky.social #antimicrobials2025 #ASA2025 #globalpublichealth #MDRI

📣 Medical editors call for #action against the decisions being taken in the #USA undermining #medicine and #science, and international #coordination to preserve what has been built across borders. #IDSky #Clinmicro #MedSky #Episky #publichealth #vaccines www.cmi-comms.com/article/S295...

Re-emergence of Oropouche virus in Brazil and Latin America www.thelancet.com/journals/lan...

Are you researching #malaria? The datasets we host harmonise tens of thousands of individual patient data, enabling researchers to answer new questions from existing data. Learn more www.iddo.org/wwarn/w...#malaria?#DataReuse #DataForGood

Modelling paper using data from prospective clinical trials highlights major impact of higher doses of primaquine and tafenoquine on P.vivax recurrences and #vivax transmission. Coverage, adherence and safety will be key elements in implementation. www.thelancet.com/journals/lan...

Understanding the factors affecting patient adherence to primaquine treatment will inform better interventions targeting #vivax radical cure. This study from Thai-Myanmar border provides great insights. journals.plos.org/globalpublic...

Clinical trial in Cambodia, once again highlighting that higher total doses of primaquine (7mg/kg) are needed to achieve high antirelapse cure rates in patients with #vivax malaria. Plus reassuring safety data. www.medrxiv.org/content/10.1...

Poverty is one of biggest determinants of outcome from #TB . Cases & mortality in impoverished communities were halved by the Brazilian Bolsa Família (conditional cash transfer). Non randomised cohort study, but great results. www.nature.com/articles/s41...

AKI following SAB occured in 48% and associated with 28 day mortality (OR=3.8). "Some AKI phenotypes have rapid resolution, which supports consideration of delayed antimicrobial dose reduction." @gurujosh.bsky.social

Outbreak of yellow fever in the Americas Region:24 deaths out of 50 confirmed cases. On this International Day of #EpidemicPreparedness we are reminded of the risk of re-emergence of old threats and the importance of #research and #vaccination @yellow4flavi.bsky.social www.paho.org/sites/defaul...

Researching #malaria in pregnancy? Check out the malaria in pregnancy library, an online resource to search published and unpublished literature @wwarnnews.bsky.social www.iddo.org/wwarn/malari...

Jimmy Carter

Fungal pathogens not constrained to previously considered endemic areas.

Latest "WHO Guidelines for Malaria" finally published. 460+ pages with recommendations spanning vector control, treatment, vaccination, chemoprevention and elimination strategies. Several major changes for radical cure of #vivax #malaria www.who.int/publications...

Rise of tinae corporis due to Trichophyton indotinae esp in patients linked to South Asia. High rates of terbinafine resistance and 5% poor response to itraconazole wwwnc.cdc.gov/eid/article/...

Suboptimal mg/kg dosing of CQ and PQ is a major factor in treatment failure for #vivax malaria jkms.org/DOIx.php?id=...

Weekly DHA-piperaquine for chemoprophylaxis of #malaria in children under 5 with sickle cell anaemia... Much more effective than monthly SP www.thelancet.com/journals/lan...

AL reduces #malaria transmission far more than AS-AQ in West Africa. Plus reminder of major benefits of single low dose primaquine www.sciencedirect.com/science/arti...

Antibiotic use increased 16.3% since 2016, driven largely by economic growth in LMIC. Despite concerns on AMR, effective measures like stewardship programs, public awareness, improved infection prevention have helped some high-income nations limit their consumption. www.pnas.org/doi/10.1073/...

It's that time of year again. Here are my top 10 ID papers of 2024 1. My opinion 2. Practice changing, paradigm-shifting or dogma challenging 3. Not COVID 4. Alphabetical order by first author 5. CoI for 4 and 5 (I am an author) Summary slide here, details in thread #IDSky #Top10IDpapers

The new WWARN #Vivax library contains data from 301 clinical trials, & case reports from 433 sites published since 1960 across 39 countries. Use it free for your #Malaria research www.iddo.org/wwarn/wwarn-...

RTS/S, R21 and now hopefully RH5 not too far behind. Promising results of Phase 2b trial in Burkina Faso especially in high density infections. But unknown longevity www.thelancet.com/journals/lan...

24 strains of S. maltophilia were treated with Cefiderocol which is the largest real-life series to date The results confirm real-world efficacy of Cefiderocol in S. matlophilia infections, for which therapeutic armamentarium is limited #idsky #EMIMCC

🆕💫 RETROSPECTIVE Cutibacterium acnes infective endocarditis—an emerging pathogen The incidence of endocarditis caused by C.acnes is alarming and is at par with the HACEK group Blood culture-negative IE was initially reported in 54.3% of the patients😲 #idsky academic.oup.com/ejcts/articl...

Political unrest, armed conflict, economic turmoil and unstable health care systems undermining malaria elimination... www.sciencenews.org/article/mala...

In Ep 2 of our #DrugDiscoveryExplained series, our Senior Discovery Project Manager Fanny explains what high-throughput screening is, and how we can screen hundreds of thousands of #molecules in just a few days. 🎬View the video here: www.instagram.com/p/DDjOpsWoT0c/ 🔗Webpage: bit.ly/4iCi67E

Brilliant article by Mehr et al. Modelling #vivax dynamics using a unique cohort of children followed every day for 21 months. Mean hypnozoite dormancy is 6 months and likely activated by symptomatic malarial illness doi.org/10.1073/pnas...

First trial ADAPT Sepsis, presented by Paul Dark, Warwick University. Concurrent in @jama.com jamanetwork.com/journals/jam... Adults receiving IV abx for suspected sepsis; abx discontinuation according to PCT or CRP monitoring daily vs standard care; outcomes - days abx use and 28d mortality

Once again! Anidulafungin exposure and population pharmacokinetics in critically ill patients with invasive candidiasis Standard anidulafungin dosing is insufficient for achieving adequate exposure in critically ill patients Clinically?! #idsky #medsky ##EMIMCC link.springer.com/article/10.1...

BALANCE study in NEJM - no difference in between 7 vs 14 days ABs for blood stream infections. Reassuring, but most of these uncomplicated infections we wouldn't go passed 7 days anyway www.nejm.org/doi/full/10....

2024 surge in #dengue. Over 12 million cases have been reported in North, Central, and South America and the Caribbean. www.cdc.gov/dengue/outbr...

#Chagas disease is treatable, but tracking treatment success is tough. 🔬 A new serological test could change that, offering a way to measure whether the parasite has been cleared from the body. 🔗 Read more here: nature.com/articles/s41...

🆕🔥 systematic review and meta-analysis #CMIJournal 6 RCTs,10 adjusted cohorts& 22 unadjusted cohorts N=11,566 Early transition to oral antibiotics was noninferior to continued IV antibiotic treatment for bacteraemia & sepsis #idsky #medsky www.clinicalmicrobiologyandinfection.com/article/S119...

Imported cases of #malaria into UK is at the highest level in at least 24 years

The diving beetle you never knew was your friend against vector borne viruses.... www.itg.be/en/health-st...

Thread for those new to BlueSky. First of all, welcome. It feels like a safer space, doesn’t it? But also perhaps a bit disorienting initially? Here’s some tips for getting your bearings.

A little-known virus is getting a lot of attention this year. #Oropouche has been making headlines. >10,000 cases, mainly in South America & the Caribbean www.npr.org/sections/goa...

Universal Vital Assessment (UVA) outperforms MEWS and qSOFA in predicting in-hospital mortality. ? a valuable clinical tool for high-risk patients in resource-limited settings www.thelancet.com/journals/ecl...

Hi #IDSky! Febrile is a cultured podcast about all things ID. We talk about clinical reasoning, diagnostics, abxs, and other interesting topics! 🦠 We love showcasing trainees and ID clinicians, and we cover both adult+pediatric topics/cases. We're ~4 years old and sponsored by @idsainfo.bsky.social

Microhaplotype genotyping now available for exploring #Plasmodium #vivax infection dynamics. Huge potential for improving our understanding of P.vivax clinical trials #IDSky www.sciencedirect.com/science/arti...

Time to stop funding/doing more vit D in TB trials?

The new WWARN #Vivax library contains data from 301 clinical trials, & case reports from 433 sites published since 1960 across 39 countries. Use it free for your #Malaria research. www.iddo.org/wwarn/wwarn-...