Paul Norman
@pn0rmski.bsky.social
📤 497
📥 67
📝 46
Immunology (still not in mice)
academic.oup.com/gbe/advance-...
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Archaic Introgression Shapes Genetic Variation at Loci Associated With DNA Virus Load in Modern Humans
Abstract. Archaic introgression has shaped the modern human immune system, particularly components involved in RNA virus responses. In contrast, its contri
https://academic.oup.com/gbe/advance-article/doi/10.1093/gbe/evag110/8664352
8 days ago
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www.cell.com/ajhg/fulltex...
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Signatures of pathogen-driven selection and Austronesian gene flow of Papua New Guinea HLA alleles
Polymorphism of human leukocyte antigens (HLA) guides differential immune responses to infection. We analyze how HLA evolved across the distinct environments of Papua New Guinea. We find that HLA dive...
https://www.cell.com/ajhg/fulltext/S0002-9297(26)00156-4
20 days ago
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Abstract submission and registration for the 3rd annual SIP in Sassenheim-The Netherlands is open. Take advantage of the early bird fee of only Euro 775 which does include 3 overnight hotel stay and all conference meals.
sip-sassenheim.org
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SIP Symposium |
https://sip-sassenheim.org/
2 months ago
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haematologica.org/article/view...
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Integrating killer cell immunoglobulin-like receptor highresolution genotyping for predicting transplant outcomes in allogeneic hematopoietic stem cell transplantation | Haematologica
https://haematologica.org/article/view/12166
3 months ago
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www.oxforduniversitystores.co.uk/conferences-...
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Oxford KIR Workshop 2026 | University of Oxford
An international gathering of scientists studying the killer-cell immunoglobulin-like receptors (KIR). It will cover topics such  evolution, immunogen
https://www.oxforduniversitystores.co.uk/conferences-and-events/finance/finance/oxford-kir-workshop-2026
7 months ago
0
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www.youtube.com/watch?v=KALZ...
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The Genes That Encode T-Cell Receptors and B-Cell Receptors
YouTube video by Society for Immune Polymorphism
https://www.youtube.com/watch?v=KALZJUppRa4&t=11s
7 months ago
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reposted by
Paul Norman
Malcolm Sim
8 months ago
We're hiring! Come join our lab in Oxford as a research assistant and study peptide recognition of MHC molecules - please reach our for more details!
www.jobs.ac.uk/job/DOW691/r...
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Research Assistant at University of Oxford
An opportunity for an academic position as a Research Assistant is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.
https://www.jobs.ac.uk/job/DOW691/research-assistant
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There are 4 places left at the SIP Symposium 2025. Hurry up and register before you miss your chance..
sip-sassenheim.org
8 months ago
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reposted by
Paul Norman
Thiago Carvalho
8 months ago
'Superresolution microscopy has revealed a nanoscale rearrangement of NK cell receptors at the cell surface upon cellular activation. An emerging idea is that the activation and inhibition of immune cells is influenced by the nanoscale proximities of receptor clusters'
www.pnas.org/doi/10.1073/...
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Nanoscale restructuring of the immune synapse with an engager enhances NK cell function | PNAS
Engagers are antibody-based therapies which bind immune cell receptors and a target cell ligand. Next-gen engagers typically bind two activating re...
https://www.pnas.org/doi/10.1073/pnas.2507336122
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immunepolymorphism.square.site
🧪
8 months ago
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ucsf.zoom.us/webinar/regi...
9 months ago
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Society for Immune Polymorphism Memberships are now available through SquareUp. Join today and receive membership through end of 2026. We offer a range of membership types. Visit this storefront to join the society.
immunepolymorphism.square.site
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Home | Society for Immune Polymorphism
https://immunepolymorphism.square.site/
9 months ago
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Balking tradition, we will NOT be extending the abstract deadline for the Society for Immune Polymorphism Symposium, as we have lots of exciting abstracts to choose from already. If you would like to attend, there are still some spots available for registration:
sip-sassenheim.org/registration/
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Registration | SIP Symposium
https://sip-sassenheim.org/registration/
9 months ago
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news.cuanschutz.edu/dbmi/genome-...
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CU Anschutz Researchers Help Build One of the Most Inclusive Human Genome Maps to Date
CU Anschutz researchers contribute to one of the most inclusive human genome maps created, advancing disease research and precision medicine through groundbreaking genetic diversity insights.
https://news.cuanschutz.edu/dbmi/genome-mapping
10 months ago
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www.jbc.org/article/S002...
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Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2
HLA class I alleles of archaic origin may have been retained in modern humans because they provide immunity against diseases to which archaic humans had evolved resistance. According to this model, ar...
https://www.jbc.org/article/S0021-9258(25)02393-2/fulltext
10 months ago
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link.springer.com/article/10.1...
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Molecular Interactions Between NK Cells and Acute Leukemic Cells: KIR2DL5 Drastically Limits NK Cell Responses - Journal of Clinical Immunology
Natural Killer (NK) cells naturally recognize and eliminate leukemic cells. However, the molecular interactions that govern these responses are diverse due to the large number of activating and inhibi...
https://link.springer.com/article/10.1007/s10875-025-01913-y
10 months ago
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www.ashg.org/publications...
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ASHG Announces 2025 Professional Award Recipients
For Immediate Release: Tuesday, July 29, 2025, 10:00 a.m. U.S. Eastern Time Media Contact: Evelyn Mantegani, (301) 634-7300,
[email protected]
Rockville, Md. – The American Society of Human Genetics (ASH...
https://www.ashg.org/publications-news/ashg-news/ashg-announces-2025-professional-award-recipients/
10 months ago
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reposted by
Paul Norman
Nandita Garud
10 months ago
I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (
garud.eeb.ucla.edu
). If interested, please message me!
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Garud Lab
https://garud.eeb.ucla.edu
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www.nature.com/articles/s41...
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Complex genetic variation in nearly complete human genomes - Nature
Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.
https://www.nature.com/articles/s41586-025-09140-6
10 months ago
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sip-sassenheim.org
10 months ago
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reposted by
Paul Norman
Ed Chuong
10 months ago
Are you bravely deciding to do a postdoc in the US? And also interested in some combination of genomics, immunology, and transposons? If so, consider applying to my lab at the BioFrontiers Institute in Boulder, Colorado!
jobs.colorado.edu/jobs/JobDeta...
🧪🧬
#TESky
#interferosky
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sip-sassenheim.org/speakers/
11 months ago
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SIP 2025: Final line up of speakers announced today
sip-sassenheim.org/speakers/
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Speakers | SIP Symposium
https://sip-sassenheim.org/speakers/
11 months ago
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Society for Immune Polymorphism annual meeting November 3-5 2025. Abstracts due August 15th.
sip-sassenheim.org?_gl=1%2Ato8b...
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SIP Symposium |
https://sip-sassenheim.org/?_gl=1%2Ato8bwb%2A_ga%2AMTYxMTA2NTM1MS4xNzUwMjA5MzUx%2A_ga_1XMLEQVVNS%2AczE3NTA3NzY5MjEkbzIkZzEkdDE3NTA3NzcwMTkkajU1JGwwJGgw
11 months ago
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reposted by
Paul Norman
Waggoner Lab
11 months ago
Florian Krammer lab looking for a postdoc in virology/immunology at the Ignaz Semmelweis Institute at the Medical University in Vienna.
www.meduniwien.ac.at/web/karriere...
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Nr24 Ignaz Semelweis Institut, Reference number 382/25 | MedUni Wien
https://www.meduniwien.ac.at/web/karriere/offene-stellen/personalmitteilungsblatt-nr24/25/nr24-ignaz-semelweis-institut-reference-number-382/25/
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www.nature.com/articles/s41...
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RIFINs displayed on malaria-infected erythrocytes bind KIR2DL1 and KIR2DS1 - Nature
Certain RIFINs from Plasmodium falciparum can bind to both inhibitory (KIR2DL1) and activating (KIR2DS1) immune receptors on natural killer cells, demonstrating the potential role of activating killer...
https://www.nature.com/articles/s41586-025-09091-y
11 months ago
0
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MAIT cells exacerbate colonic inflammation in a genetically diverse murine model of spontaneous colitis
www.sciencedirect.com/science/arti...
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MAIT cells exacerbate colonic inflammation in a genetically diverse murine model of spontaneous colitis
IL-17-producing lymphocytes are involved in both tissue repair and the propagation of inflammation, with their effects highly context-dependent. Mucos…
https://www.sciencedirect.com/science/article/pii/S1933021925000534
12 months ago
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sip-sassenheim.org?_gl=1%2Ajqbh...
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SIP Symposium |
The Society for Immune Polymorphism is dedicated to understanding the genetic and functional variation of the vertebrate immune system, and the immune system’s role in evolutionary biology, disease and health.
https://sip-sassenheim.org/?_gl=1%2Ajqbhvg%2A_ga%2AMjYzMzc0MTcwLjE3NDE3MDIwNzM.%2A_ga_1XMLEQVVNS%2AczE3NDgzNTgzNDckbzIzJGcxJHQxNzQ4MzYwODg2JGowJGwwJGgw
12 months ago
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The one in which we finally lay the HLA vs mate selection debate to rest ...?
www.biorxiv.org/content/10.1...
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No evidence for disassortative mating based on HLA genotype in a natural fertility population
Evidence for disassortative mating based on the human-specific MHC, i.e. HLA, is equivocal1. Initial evidence for disassortative HLA-pairing in the European-descent Hutterites2 has tended not to repli...
https://www.biorxiv.org/content/10.1101/2025.05.06.652536v1
about 1 year ago
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We are pleased to announce the availability of two Frans Claas Travel Awards, each valued at €1000, to support early-career researchers attending the 2nd annual SIP Symposium. The awards are offered by the TxMiller Foundation.
sip-sassenheim.org/registration...
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Frans Claas Travel Awards | SIP Symposium
https://sip-sassenheim.org/registration/frans-claas-travel-awards/
about 1 year ago
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reposted by
Paul Norman
Malcolm Sim
about 1 year ago
Delighted to be hosting the next KIR workshop in Oxford next year. Please save these dates if you're interested. More details to follow.
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sip-sassenheim.org/speakers/?_g...
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Speakers | SIP Symposium
https://sip-sassenheim.org/speakers/?_gl=1*f9ujdn*_ga*ODAyMDA5Mjk2LjE3NDE3MDYwOTU.*_ga_1XMLEQVVNS*czE3NDY3MzEzMDkkbzE3JGcwJHQxNzQ2NzMxMzA5JGowJGwwJGgw
about 1 year ago
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reposted by
Paul Norman
Denis Wirtz
about 1 year ago
A huge majority of Americans (77%) oppose the cuts to medical research that the current administration has made. (Source: Wash. Post/ABC/Ipsos poll)
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reposted by
Paul Norman
The American Association of Immunologists
about 1 year ago
Data in
@jimmunol.bsky.social
revealed the role of
#malaria
in Burkitt lymphoma, the most common childhood cancer in equatorial Africa and New Guinea. Reducing malaria could also reduce Burkitt
#lymphoma
said @rosemaryroch4d, who led the study
@cuanschutz.bsky.social
. Learn more:
ow.ly/tTKg50VI6qR
.
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Study Identifies How Malaria Can Lead to Childhood Cancer - AAI News
New data in The Journal of Immunology uncovered the role of malaria in the development of Burkitt lymphoma, the most common childhood cancer in equatorial Africa and New Guinea.
https://ow.ly/tTKg50VI6qR
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Give money, get book
about 1 year ago
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reposted by
Paul Norman
Malcolm Sim
about 1 year ago
Delighted that this review is now accepted and online. We review evidence from us and others that germline-encoded receptors of the innate immune system can detect peptides presented by MHC molecules, some with high peptide-specificity.
t.co/9EKH2SpGEy
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https://academic.oup.com/ooim/advance-article/doi/10.1093/oxfimm/iqaf003/8115587
https://t.co/9EKH2SpGEy
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Extremely honoured to host Prof. Josephine Pemberton FRS at the second annual
#SocietyforImmunePolymorphism
symposium Nov 3-5, 2025
about 1 year ago
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reposted by
Paul Norman
Jerad Walker
about 1 year ago
50 years ago the BBC filmed this incredible documentary about Shrewsbury Town FC’s ball boy who was a grown ass man named Fred who owned a tiny boat.
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And we are holding another one this year!
sip-sassenheim.org
#ImmunoSky
#EvolSky
add a skeleton here at some point
about 1 year ago
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Honored to announce that John Trowsdale will be giving the van Rood Prize lecture at this year's Society for Immune Polymorphism meeting
sip-sassenheim.org/speakers/
November 3-5th
about 1 year ago
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sip-sassenheim.org
about 1 year ago
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Stunning show by Techno OGs Kraftwerk in Denver last night.
about 1 year ago
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Everything is going to work out just fine
about 1 year ago
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reposted by
Paul Norman
Malcolm Sim
about 1 year ago
academic.oup.com/jimmunol/adv...
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Peptide selectivity of killer cell immunoglobulin-like receptors differs with allotypic variation in HLA class I
Abstract. Natural killer (NK) cell activation is regulated by killer cell immunoglobulin-like receptors (KIRs) that recognize human leukocyte antigen (HLA)
https://academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf003/8092612
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The Case of a Missing HLA-B Gene
onlinelibrary-wiley-com.proxy.hsl.ucdenver.edu/share/BRHU5C...
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CU Anschutz Off-Campus Access (EZProxy)
https://onlinelibrary-wiley-com.proxy.hsl.ucdenver.edu/share/BRHU5CCENQIAGJYTIDFH?target=10.1111/tan.70114
about 1 year ago
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reposted by
Paul Norman
Waggoner Lab
about 1 year ago
Biomedical value of studying human diversity spotlighted by 5-nation asian Immune Diversity Atlas (AIDA) of circulating immune cells from healthy donors
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social
@jayshin.bsky.social
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reposted by
Paul Norman
Waggoner Lab
about 1 year ago
Regulatory T cells with engineered specificity for HLA-DQ2.5–restricted deamidated gluten peptides exert bystander suppression in vivo
www.science.org/doi/10.1126/...
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reposted by
Paul Norman
Waggoner Lab
about 1 year ago
Long terminal repeats & PRDM9 binding motifs in recombination hotspots potentially contribute to diversification of the KIR repertoire in NK cells
doi.org/10.1093/jimm...
@jimmunol.bsky.social
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www.youtube.com/@SocietyforI...
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Society for Immune Polymorphism
https://www.youtube.com/@SocietyforImmunePolymorphism/videos
about 1 year ago
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reposted by
Paul Norman
JillahJillah PhD, MPH
about 1 year ago
Latest from my lab, congrats to PhD student Jacquie Williams on her first first author paper 🎉🎉🎉
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Copy number variation at the complement C4 locus is associated with risk for multiple sclerosis - Jacqueline Williams, Wesley M Marin, Kristen J Wade, Rayo Suseno, Kerry Kizer, Stacy Caillier, Danillo...
Background: The complement system has been suspected to play a role in multiple sclerosis (MS) due to presence of complement activation products in MS lesions. ...
https://journals.sagepub.com/doi/10.1177/13524585251324850
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