Tim Humphrey
@humphreylab.bsky.social
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Chromosome Integrity Group, Genome Damage and Stability Centre, University of Sussex.
Delighted to wave the flag for
@gdsc-sussex.bsky.social
@sussexcancer.org
@sussexbcr.bsky.social
sussexcancerfund.co.uk
together with Rhys Morgan at the Science Cafe, MacMillan Horizon centre today. Thanks to Rebecca Herbertson and Stephen Robinson for organizing.
@rhysmorganlab.bsky.social
about 1 month ago
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Tim Humphrey
Jasmeen Oberoi
2 months ago
🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab
@gdsc-sussex.bsky.social
investigating structure and function of fusion kinase complexes in Leukaemia. 📅 Deadline: 29th September 2025. 🙏 Please share with anyone who might be interested.
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Research Technician – Protein Biochemistry at University of Sussex
Explore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
https://www.jobs.ac.uk/job/DOP599/research-technician-protein-biochemistry
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MarĂa Fernández-Casañas
2 months ago
So pleased to see my PhD project published, great work by everyone involved! Together we uncovered how regulation of the BTRR complex is crucial to protect centromeres during mitosis.
add a skeleton here at some point
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Tim Humphrey
Genome Damage and Stability Centre (GDSC)
2 months ago
#New-Paper
Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.
doi.org/10.1038/s415...
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DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
https://doi.org/10.1038/s41586-025-09470-5
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Tim Humphrey
Uli Rass
2 months ago
My first post on bsky to share our latest research in
@nature.com
: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators &
@ukri.org
@acmedsci.bsky.social
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DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
https://www.nature.com/articles/s41586-025-09470-5
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Tim Humphrey
Australasian Epigenetic Alliance (AEpiA)
3 months ago
🧬 The 2025 Emma Whitelaw ECR publication award is now open! Full T&Cs and application form are on the AEpiA website
www.aepia.org.au/emma-whitela...
We can't wait to see the exciting research that has been published over the last year!
#epigenetics
#ECR
#research
#AEpiA
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Emma Whitelaw Publication Award — Australasian Epigenetics Alliance
https://www.aepia.org.au/emma-whitelaw-publication-award
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Tim Humphrey
Genome Damage and Stability Centre (GDSC)
5 months ago
Prof. Evi Soutoglou describing what happens when DNA breaks, and when to cut, and when not to — on Brighton seafront, as part of Soapbox Science 2025 — a public outreach platform that promote women and non-binary scientists and the science that they carry out. ‪@soapboxscience.bsky.social‬
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Tim Humphrey
Genome Damage and Stability Centre (GDSC)
5 months ago
Dr. Luke Yates, along with Prof. Zhang and Prof. Burgers, summarise our current mechanistic understanding of the DNA damage checkpoint; inc. structural studies of ATM and ATR and how these work together to prevent cancer.
doi.org/10.1146/annu...
@layates.bsky.social
@crick.ac.uk
@washu.bsky.social
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DNA Damage and Replication Stress Checkpoints | Annual Reviews
DNA damage checkpoints are key regulatory signaling cascades that arrest cell cycle progression upon DNA damage or upon DNA replication stalling and allow time for repair or correction. Failure to eli...
https://doi.org/10.1146/annurev-biochem-072324-031915
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Tim Humphrey
Sussex Cancer Research Centre
8 months ago
Exciting to see SCRC Creative Community Engagement project led by Deborah Humphrey, and Karina Patfield, highlighted on BBC news. "Words from the Waiting Room offers cancer patients, survivors, and supporters a safe environment to express themselves"
sussexcancer.org/news/bbc-new...
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BBC News, South East covers Words from the Waiting Room. — Sussex Cancer Research Centre
Creative Community Engagement project led by Deborah Humphrey, and Karina Patfield highlighted on BBC news. Words from the Waiting Room offers cancer patients, survivors, and supporters a safe enviro...
https://sussexcancer.org/news/bbc-news-south-east-covers-words-from-the-waiting-room
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Congratulations to Dr Stephen Robinson for launching the Sussex Brain Tumour Research Group. @sussexcancer.bsky.social
8 months ago
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Tim Humphrey
Sussex Cancer Research Centre
9 months ago
It is
#WorldCancerDay
We are excited to announce our funded research projects, a new community engagement strategy, creative award winners, and interviews.
sussexcancer.org/news/announc...
@bsmsmedschool.bsky.social
@sussexuni.bsky.social
@uniofbrighton.bsky.social
@eshtnhs.bsky.social
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Updates from the Sussex Cancer Research Centre on World Cancer Day. — Sussex Cancer Research Centre
The theme of World Cancer Day 2025 is “United by Unique”, which places people at the centre of care and their stories at the heart of the conversation. Today the Sussex Cancer Research Centre (SCR...
https://sussexcancer.org/news/announcements-from-the-sussex-cancer-research-centre-on-world-cancer-day
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Tim Humphrey
Ester Hammond
10 months ago
Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from
@halaestephan.bsky.social
www.embopress.org/doi/full/10....
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Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation | The EMBO Journal
imageimageHypoxia contributes to cancer resistance to both standard therapies and immunotherapy. This work demonstrates that tumor hypoxia promotes immune evasion by autophagy-mediated downregulation ...
https://www.embopress.org/doi/full/10.1038/s44318-024-00319-7
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Tim Humphrey
Sussex Cancer Research Centre
11 months ago
Today we celebrate our inspirational co-director Professor Melanie Flint m as she gives her inaugural lecture
@brightonuni.bsky.social
An incredible scientist, leader, mentor, and all around amazing person.
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Tim Humphrey
Sussex Cancer Research Centre
12 months ago
Co-directors
@humphreylab.bsky.social
and
@siftw.bsky.social
were at Parliament today, celebrating 20 years of Brighton and Sussex Medical School, and working to make sure cancer research is at the centre of the next 20 years.
@sussexuni.bsky.social
@brightonuni.bsky.social
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Great to join you here today and looking forward to some blue sky science chat!
12 months ago
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