"One important implication of our findings is that remodelers are not inherently activating or silencing." --Yeah man. 100% "Instead, remodeler activity can position nucleosomes in configurations that can be exploited by different chromatin modifying enzymes or reader proteins." --interesting idea!

The FPbase spectra viewer just had it's biggest software refactor in 6 years. It *should* be largely invisible to the end user (hopefully just faster and less buggy). Please let me know if you find any issues as you use it! www.fpbase.org/spectra/

🚨 We are recruiting postdocs! If you're interested in reproductive, stem cell/developmental biology, and/or women's health, please apply! 📝 Please repost! 🚩 More info here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...

1/ Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)

🧪Job opening at Janelia @hhmijanelia.bsky.social Integrative Imaging platform for a bioimage analyst. Please repost.

Our review on Light sheet illumination in single-molecule localization microscopy for imaging of cellular architectures and molecular dynamics is now published in npj Imaging! Check it out here: doi.org/10.1038/s443...

New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today: SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion! www.sciencedirect.com/science/arti... 1/

Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs. bioart.niaid.nih.gov

We just posted a preprint about a death mechanism that we find truly surprising. When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?! preprint here and a thread (1/n): www.biorxiv.org/content/10.1... 🧪

Thrilled to share Luis' manuscript showing how bacterial ribonucleoprotein bodies (BR-bodies) control RNA metabolism: stress changes the bacterial biomolecular condensate material state *and* shifts function from mRNA decay to storage. #LiveCell #SingleMolecule #Microscopy @schraderlab.bsky.social

Stress Changes the Bacterial Biomolecular Condensate Material State and Shifts Function from mRNA Decay to Storage https://www.biorxiv.org/content/10.1101/2024.11.12.623272v1