Some more fun #mitochondria science for Friday, from Bioenergetics 4th edition by Nicholls & Ferguson. Mitochondrial charge, respiration, and oxidant production relationships: 🧪

Excellent review on mitochondria and inflammation exploring how endosymbiosis may explain some things. 🧪 www.nature.com/articles/s41...

A mitochondrial origin for inherited diabetes mellitus 🧪 www.nature.com/articles/s41...

Excellent review on mitochondria and inflammation exploring how endosymbiosis may explain some things. 🧪 www.nature.com/articles/s41...

Some more fun #mitochondria science for Friday, from Bioenergetics 4th edition by Nicholls & Ferguson. Mitochondrial charge, respiration, and oxidant production relationships: 🧪

How do proteins get into mitochondria? Another graphic from Bioenergetics 4th edition by Nicholls & Ferguson: 🧪

How do proteins get into mitochondria? Another graphic from Bioenergetics 4th edition by Nicholls & Ferguson: 🧪

Studying mitochondria in isolation has revealed complex bioenergetic relationships that are useful for understanding physiology in general. More good stuff from Bioenergetics 4th edition by Nicholls & Ferguson 🧪

"We breathe at the molecular level when mitochondria in our cells consume oxygen to extract energy from nutrients." Great first sentence of an abstract from this paper: www.science.org/doi/10.1126/...

Hey. The fragmentation of the social media landscape has been hard on indie #scicomm 🧪 projects So if you'd like to follow a podcast that's enthusiastic about #linguistics, could you check out @lingthusiasm.bsky.social? And if you think your followers might like to, could you give this a repost?

Studying mitochondria in isolation has revealed complex bioenergetic relationships that are useful for understanding physiology in general. More good stuff from Bioenergetics 4th edition by Nicholls & Ferguson 🧪

Mitochondria are the powerhouse of the cell

Mitochondria move around in cells 🔋🏎️ Heres another nice diagram from Bioenergetics 4th edition by Nicholls & Ferguson: 🧪

Mitochondria use an electro⚡chemical🧪 proton gradient. It's usually mostly electric potential, but different circumstances can increase the contribution of diffusion potential. A deep cut from Bioenergetics 4th edition by Nicholls & Ferguson 🔋

Mitochondria use an electro⚡chemical🧪 proton gradient. It's usually mostly electric potential, but different circumstances can increase the contribution of diffusion potential. A deep cut from Bioenergetics 4th edition by Nicholls & Ferguson 🔋

Mitochondria are little circuits in our cells. 🔌⚡💡🔋 Helpful analogy for interpreting many bioenergetics experiments. Another great figure from Bioenergetics 4th edition by Nicholls & Ferguson. 🧪

Lift some weights! 💪 It doesn't take too much to protect your heart 🫀 and health 🧪 New @American_Heart statement: professional.heart.org/en/science-n...

"systemic immune and inflammatory responses may lead to more severe illness in some patients" SARS-CoV-2 can damage mitochondrion in heart, other organs, study finds. Would B12 help? B12 would help. #helpmechangethefuture CDC case# 1232781-B4W6H4 www.cidrap.umn.edu/covid-19/sar...

What is human aging? We still don't really know, but our organs might predict healthy versus unhealthy aging. 🧪 www.nature.com/articles/s41...

Mitochondria, inflammation, and cardiovascular disease each influence one another. Interesting read: 🧪 journals.physiology.org/doi/abs/10.1...

Replacing damaged mitochondria with new ones could be important for many human diseases; high-quality causal studies are needed to start translating this growing evidence. 🧪 www.nature.com/articles/s42...

Mitochondrial power and cardiac aging:🔋🫀🧪 Great review article on one of my favorite broad topics: www.ncbi.nlm.nih.gov/pmc/articles...

"Politicians don't understand science" ... say the key science advisers during an inquiry that was set up to investigate how prepared the United Kingdom was for the COVID-19 pandemic. I say "duh!" 🧪 www.nature.com/articles/d41...

Mitochondrial power and cardiac aging:🔋🫀🧪 Great review article on one of my favorite broad topics: www.ncbi.nlm.nih.gov/pmc/articles...

Can looking at muscle mitochondria predict how sick older people may be? Looks like yes. Mitochondrial decline is likely both a cause and a consequence of biological aging. 🧪 unreviewed preprint: www.medrxiv.org/content/10.1...

i’m a metabolism scientist at city of hope who can’t stop thinking about NAD coenzymes have some exciting results on a rare disease as well what interests you?

Great reminder that ATP levels are maintained constantly; the cell and mitochondria are always working to keep ATP disequilibrium to power everything. Don't forget about the phosphocreatine system. 🧪 www.nature.com/articles/s42...

Great reminder that ATP levels are maintained constantly; the cell and mitochondria are always working to keep ATP disequilibrium to power everything. Don't forget about the phosphocreatine system. 🧪 www.nature.com/articles/s42...

Would adding "in mice" to the titles of high-profile research articles help prevent the media frenzies that often fuel public distrust of science? 🧪

Interesting thoughts on mitochondrial charge 🔋 and aging (featuring some analysis of my own work) 🧪 www.mdpi.com/1422-0067/24...

SGLT2 inhibitors may improve heart function by rewiring metabolism through mitochondria using ketones 🧪 academic.oup.com/cardiovascre...

If there's one thing I've learned being Very Online it is this: Just because an person had an opinion you agreed with once, or made something you liked, doesn't mean they are A. At all smarter than you B. Qualified to speak on literally anything else C. Worthy of any power or influence

SGLT2 inhibitors may improve heart function by rewiring metabolism through mitochondria using ketones 🧪 academic.oup.com/cardiovascre...

It's often forgotten that Dr. Jennifer Moyle was a brilliant experimentalist and science partner of Dr. Peter Mitchell—they set out to prove how mitochondria make ATP using proton gradients. 🧪 Shamefully, Mitchell was the only one to get the Nobel Prize 🧵👇(1/4)

T cell exhaustion through metabolic reprogrammed HIF1alpha stabilization 👉🏻 cool read 🧪 #immunosky www.nature.com/articles/s41...

Surprising result, I'm interested to see where this goes: "Lactate activates the mitochondrial electron transport chain independently of its metabolism" 🧪 www.cell.com/molecular-ce...

Nuanced thinking is always required, especially for **antioxidants** and diet. 🧪 www.sciencedirect.com/science/arti...

Nuanced thinking is always required, especially for **antioxidants** and diet. 🧪 www.sciencedirect.com/science/arti...

"A hallmark of a good scientist is how they respond to criticism — are they prepared to question their own ideas and findings, or do they become defensive and attack their critics?...being self-critical and taking the criticism of others on board are surely important"

This 2019 Science Advances paper lives rent-free in my head, and I think it's the social science paper that I mention the most in everyday conversation with my peers or elders... #youths #olds #science www.science.org/doi/10.1126/...

Dinosaur mitochondria?? Dinosaurs likely had metabolism more similar to birds than to reptiles, which makes sense: 🧪 www.nature.com/articles/s41...

It's often forgotten that Dr. Jennifer Moyle was a brilliant experimentalist and science partner of Dr. Peter Mitchell—they set out to prove how mitochondria make ATP using proton gradients. 🧪 Shamefully, Mitchell was the only one to get the Nobel Prize 🧵👇(1/4)

Why are cells powered by proton gradients? 🔋🧪 Excellent article by Nick Lane www.nature.com/scitable/top...

Mitochondrial battery analogy from the earliest days in bioenergetics! 🔋🧪 Fun drawing from Peter Mitchell's biography, Wandering in the Gardens of the Mind by Prebble & Weber.

Why are cells powered by proton gradients? 🔋🧪 Excellent article by Nick Lane www.nature.com/scitable/top...

Mitochondrial battery analogy from the earliest days in bioenergetics! 🔋🧪 Fun drawing from Peter Mitchell's biography, Wandering in the Gardens of the Mind by Prebble & Weber.

Mitochondria both make and deal with oxidants ⚡ You may have heard about reactive oxygen species (ROS), free radicals, and antioxidants—mitochondria help make sure they're all balanced in cells. More good stuff from Bioenergetics by Nicholls & Ferguson 🧪

Mitochondrial functions can be modeled as a circuit. I love the battery analogy, 🔋 but this is more accurate. Another gem from Bioenergetics 4th edition by Nicholls & Ferguson. Description in replies 👇 🧪