Low intrinsic capacity is associated with a blunted exercise‐induced cognitive enhancement in physically active middle‐aged and older adults - Yates - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Skeletal Muscle and Fat-Free Mass: Related but Distinct Concepts in Body Composition www.sciencedirect.com/science/arti...

Low intrinsic capacity is associated with a blunted exercise‐induced cognitive enhancement in physically active middle‐aged and older adults - Yates - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Please repost! We have an open rank, tenure-line faculty position in biomechanics in the School of Kinesiology at the University of Michigan Ann Arbor. At U-M we have great colleagues, exceptional resources, and biomechanics can be found all across the campus. #BiomechSky

Intramuscular adipose tissue restricts functional muscle recovery www.cell.com/cell-reports...

Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions insight.jci.org/articles/vie...

#Exercise continues to be the best medicine. A personalized exercise therapy and self-management support program is more effective than usual care alone in improving health-related quality of life at 12 months in adults with multimorbidity @naturemedicine.bsky.social www.nature.com/articles/s41...

🧪 Check out our new publication @ismcopenhagen.bsky.social highlighting important considerations for using CAF as a biomarker of muscle wasting, lead by 1st author Casper Soendenbroe 💪 ⚠️Exercise timing and medication matter. onlinelibrary.wiley.com/doi/10.1002/...

Lower minute-level physical activity is associated with higher odds of cognitive impairment in older adults A&D: Transitional Research & Clinical Intervention reports activity variability could indicate cognitive health status #TRCI #AlzResearch alz-journals.onlinelibrary.wiley.com/doi/full/10....

Metabolite signatures of chronological age, aging, survival, and longevity: Cell Reports www.cell.com/cell-reports...

New @science.org Discovery of a mechanism for cancer cachexia (components of severe apathy, depression) explained by a neuroimmune circuit www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

If you’re looking to boost your brain, start exercising! Studies show that 30-60 minutes of aerobic (cardio) exercise, 3-4 times per week, can lower your risk of developing Alzheimer’s disease and other dementias. Aerobic exercise increases your heart rate and enhances blood flow to the brain.

The metabolic drivers of interferon-gamma release: glycolysis and acetyl CoA academic.oup.com/jimmunol/adv...

Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community Increased p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia www.nature.com/articles/s41...

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research | Nature Metabolism Great collaboration led by Satchin Panda and team! Happy to contribute. Time to take timing into consideration!! www.nature.com/articles/s42...

Higher levels of physical activity are linked to lower plasma p-Tau217 (blood biomarker for Alzheimer's disease) and better cognition jamanetwork.com/journals/jam...

Associations between moderate-to-vigorous physical activity, p-tau181, and cognition in healthy older adults with memory complaints: a secondary analysis from the MAPT - The Lancet Healthy Longevity www.thelancet.com/journals/lan...

Ever wondered why exercise is associated with reduced depression? Here I had the honor of highlighting a seminal finding where they showed how muscle health impacts depression.

NEWS&VIEWS | João V. Esteves & Kristin I. Stanford @osuwexmed.bsky.social The authors discuss the two studies highlighting the dual role of a novel #myokine, #Feimin, in regulating #metabolism and #exercise 💪 🐭 👥 https://bit.ly/3CNZ6mE

Poorer objective sleep quality and irregular sleep were associated with poorer functional capacity in older adults. academic.oup.com/sleep/advanc...

An immunome in 550 older adults and young adult controls demonstrated age-related changes at high-resolution along with some unique immune signatures www.thelancet.com/journals/ebi...

Brain-derived neurotrophic factor drives muscle adaptation similar to aerobic training in mice faseb.onlinelibrary.wiley.com/doi/10.1096/...

Enhancing muscle and brain resilience physoc.onlinelibrary.wiley.com/doi/10.1113/...

“exercise regimes able to induce enough stress to trigger skeletal muscle mitochondrial adaptations, based on different combinations of intensity and volume, are of benefit for all populations: (young-old) irrespective of their level of fitness. www.sciencedirect.com/science/arti...

“This study highlights the variability in physical and cognitive performance among older adults and suggests that neuroimaging markers of neurodegeneration, cSVD, and microstructural WM integrity may account for these variations. “ www.neurology.org/doi/10.1212/...

Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade www.nature.com/articles/s41...

Assessment and management of frailty in individuals living with dementia www.thelancet.com/journals/lan...

New work from our group: Senescent myoblasts exhibit an altered exometabolome that is linked to senescence-associated secretory phenotype (SASP) signalling #myoblue journals.physiology.org/doi/abs/10.1...

An international consensus on biomarkers of ageing for use in human intervention studies. academic.oup.com/biomedgeront...

Liver metabolizes high fructose corn syrup to fructose, which leads to increase production of LPC lipids that promote tumor growth. #Glycotime www.nature.com/articles/s41...

Our latest work: a new link between metabolism and proteostasis, relevant to Alzheimer's disease. Out today in Cell Chemical Biology as open access! Stay tuned for more discussion of what we found and what it means... @buckinstitute.bsky.social @cellpress.bsky.social www.cell.com/cell-chemica...