"Guys I've gambled the entire economy on this please just be cool please I'm begging you"

Slightly diminish a game: Good Mario Brothers

The world feels rough right now So please enjoy this shrimp, filmed off Cozumel, Mexico. It may be a larval reef shrimp, but we don’t know what species or how long it lives or what it eats. The world is still full of wonder and beauty and mystery. 🎥 @pedrovalenciam scuba diver on Insta

So the long story short is the President of the United States can have anyone murdered by an agent of the federal government and then direct his DOJ to essentially terminate an investigation and the evidence of the act

NEWS: In a heartbreaking video, after ICE shot and killed a woman in Minneapolis, a woman who was in the same SUV cries out: “They killed my wife. I don’t know what to do." “We stopped to videotape, and they shot her in the head,” the distraught woman sobs. www.advocate.com/news/minneso...

Currently losing my shit at this Wikipedia figure attributing Arby's to the neolithic revolution.

NASA Discovers Distant Planet With Conditions That Could Sustain Rocks https://theonion.com/nasa-discovers-distant-planet-with-conditions-that-could-sustain-rocks/

Chipotle is the "we have food at home" of eating out

Is @johngreensbluesky.bsky.social in Pittsburgh?

I'm just gonna say it: even with its own silly ridiculous plot points, the original Thrawn trilogy is a better story than the actual sequel trilogy we got.

Timeline cleanse

Hard to watch US TV media discussing how the US might occupy and run a foreign country as if it’s a perfectly normal political development.

It’s not about drugs. If it was, Trump wouldn’t have pardoned one of the largest narco traffickers in the world last month. It’s about oil and regime change. And they need a trial now to pretend that it isn’t. Especially to distract from his sinking under Epstein and skyrocketing healthcare costs.

Hard to believe 10 years ago we were on our way to completely normalizing relations with Cuba, and now our govt just casually threatens to try to coup them (again, after our countless unsuccessful attempts before, lol)

The entire philosophy of our government summed up

I don't think you non-science people realize what it takes to get a grant funded by NIH. Started experiments in Sept 2021 to generate 3 new mouse mutants to model human disease. Prelim dara shows they have relevant disease phenotypes worthy of study. Need a small grant first to characterize /1

The entire philosophy of our government summed up

Why do I have to read an Irish paper for a feature about this?

We all agree that the Oreo serving size should be roughly tripled, right?

Also developers of free software

Werner Herzog 📽️

Someone near me is selling an actual hornet nest on facebook marketplace $150

A lot hate for this article due to it being positive on LLMs. For me, it's the very specific way the article ends: "Considering the benefits, what are you waiting for?" That's the rhetorical device of a used car salesman. Any time someone tells me to "get on board", I am twice as likely not to.

I know that the discourse around MDPI journals sort of dissipated over the past year, but over at the "International Journal of Molecular Sciences" (IF 4.9) there are still 230 special issues accepting submissions before end of year! I'm sure that's normal for reputable journals.

Requested a correction from @princetonupress.bsky.social. Let's see what happens.

When the 🎄 hits your eye like a big pizza pie

When the 🎄 hits your eye like a big pizza pie

No one says to legit business owners, "hey I see there's an underground market selling toxic knock-offs of your product: how will you incorporate the toxic product AND protect your customers against its harms?" But apparently it's fine to make this suggestion to educators with respect to AI.

Looking for a Christmas miracle for a kitty (aging parent situation) for Baltimore pals: (1/2) ""My mom can no longer keep Angelo (alas!!!) and we are looking to rehome him. Angelo is a total sweetheart. He is 6 years old, gentle, playful, friendly, and a lovebug."

No matter how many times I see the Star Wars Holiday Special, I'm still not mentally prepared for the cooking show where a man in blackface plays a four-armed woman in a stereotypical 70's cooking show

a brief summary of what it’s like to be online in 2025

I love this

Also true for cats

A good reminder that not only is mass surveillance increasing at an alarming rate in the US, it's often being done in extremely insecure ways that end up being a threat to public safety www.youtube.com/watch?v=vU1-...

AI-controlled ships with nuclear armaments? Well, at least we solved the Fermi paradox.

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

I already wasn't going to ever buy a "smart fridge", you don't have to convince me even more

Love this. The knowledge that I'm most proud to have created is a critique of "foundation models", including but not limited to LLMs, based on scientific and chemical ethics. This involved a grounded theory analysis of chemical codes of ethics to define what "chemical ethics" even are.

So the current administration now reviews and signs off on all potentially controversial CBS content prior to airing? lol

This Yglesias piece in the NYT is horrifically bad. Almost every "fact" it cites is provably false. At best it is cocktail party banter from a pundit who knows nothing of energy. At worst, it was cut/paste from oil industry talking points. So, a rebuttal: www.nytimes.com/2025/12/18/o...

HAPPY HOLIDAYS TO ALL OF YOU!🎄✨

Holiday mood:

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

Every day that goes by, I become more and more demoralized by the sheer amount of tech debt being accumulated through reliance on LLMs.

Just saw this plot in a colleague's simulation analysis output, and realized it pretty accurately describes my mental state as well

This entire weekend