Carolin Klose (@carolinklose.bsky.social)

Super excited to share our new #preprint on #BioRxiv ✨ We reveal the structural basis of a partnership between the ER membrane complex (EMC) and the P5A-ATPase Spf1 — an insertase–dislocase duo that coordinates membrane protein biogenesis and quality control. www.biorxiv.org/content/10.1...

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Structural basis of an EMC:Spf1 insertase-dislocase complex in the eukaryotic endoplasmic reticulum Most eukaryotic membrane proteins are inserted into the membrane at the endoplasmic reticulum (ER). This essential but error-prone process relies on molecular quality control machineries to prevent mi... https://www.biorxiv.org/content/10.1101/2025.08.07.669073v1