Thanks to the LEO Foundation for a 2nd investment in my lab @uwdermatology.bsky.social @uwmedicine.bsky.social @uwiscrm.bsky.social. This "Serendipity Grant" lets us follow up on unexpected data in #HaileyHailey disease, a #rare #genetic #skin #blistering disorder: simpsonskinlab.org/news/simpson...

When joining a small dept @uwdermatology.bsky.social I knew finding a peer grp would be crucial—I’m grateful for a crew of junior PIs @uwiscrm.bsky.social @uwmedicine.bsky.social. At a tough time for #academic #research labs it’s helpful to have supportive colleagues to share good news & struggles 🍻

Michael Martin gave a great talk on his project @uwdermatology.bsky.social testing new Rx for #HaileyHailey disease, a #genetic #skin #blistering disorder. Thx @drsakiyama.bsky.social & @amyserafino.bsky.social for fostering undergrad collab @uwmedicine.bsky.social & @gonzagauniversity.bsky.social!

Great talk from summer student Porter from @uwsom-wwami.bsky.social. In my lab @uwdermatology.bsky.social he is studying #epidermolysis #bullosa simplex, a #genetic #skin #blistering disease most severe in newborns/children. We’ve known the #EBS cause for >30 yrs, yet still have no approved therapy.

Mixed emotions as we bid farewell to Afua to start her M.D. journey at WSU! So grateful for our 3+yr partnership as my 1st hire, who built a strong foundation for our lab @uwdermatology.bsky.social and will always be queen 👑 of western blots 🤩 Looking forward to seeing this future physician thrive!

My lab @uwdermatology.bsky.social aims to find new therapies for #EpidermolysisBullosa Simplex (EBS) a #genetic #skin #disease causing life-threatening #blistering starting at birth. Every patient deserves a chance for a cure no matter how rare their disease: www.dermatologytimes.com/view/human-s...

Awesome story about #lamellar bodies, unique #keratinocyte #organelles secreted as the “mortar” of the #epidermis that prevents our #skin from drying out. We were ecstatic to play a small part. Especially cool since the organelle was discovered decades ago by Dr Odland at @uwdermatology.bsky.social.

Karina & I were lucky to collaborate on this study by Creighton MD/PhD student & #derm applicant Justin Rudd of the Hansen Lab. Gorgeous #microscopy +omics illuminated the biology of #Odland (lamellar) bodies that were discovered @uwdermatology.bsky.social! www.nature.com/articles/s41467-025-62105-1

1st time at Society for #Pediatric #Dermatology #SPD2025 mtg to share work from my lab @uwdermatology.bsky.social. Our new project models #EpidermolysisBullosa simplex which causes painful blistering but has no approved Rx despite approval for other forms. We are working to change that for patients.

Sent a plea to @murray.senate.gov to save #NIH & #StandUpforScience. We have so much to lose from a proposed 40% cut. Labs like ours working on rare dz w/o any approved therapy will be shuttered. NIH-funded research is what allows medicine to progress, clinical trials to advance and cures to emerge.

Future of NIH in the hands of five senators. Write to them if you are in PA -McCormick WV - Moore Capito ME - Collins AL - Britt LA - Cassidy

Wonderful start to summer @uwdermatology.bsky.social. Excited to welcome @uwsom-wwami.bsky.social med student Porter & @gonzagauniversity.bsky.social undergrad Michael for summer projects on rare #skin #blistering diseases #HaileyHailey & #EpidermolysisBullosa. Thanks to Arti for a delicious lunch!

Cuts to #NIH will not only limit federal funds for clinical trials, but will also slow or halt the basic research done in labs like ours that aim to discover the next generation of therapies. This is especially devastating for so many rare diseases, most of which still lack even 1 FDA-approved drug.

Congrats to Karina PhD student @uwdermatology.bsky.social who passed her general exam to be a doctoral candidate! 🥳🍾🎉 Her thesis will leverage a novel model of epidermolysis bullosa simplex to understand the biology of this orphan genetic skin blistering disorder that has no FDA-approved therapy🧬🔬🧫👩‍🔬

Can’t wait for #SIDChicago2026 in the Windy City, where we plan to unite #epidermal #differentiation #disorder researchers from PC Project, Foundation for Ichthyosis & Related Skin Types, and our #Darier & #HaileyHailey Disease Consortium for a synergistic pre-mtg symposium on these rare diseases.

Finally, on Day 4 of #SIDSanDiego2025 we bid farewell to colleagues, alums & mentors. What an energizing @siderm.bsky.social mtg! Proud of my team & their contagious enthusiasm. We met many new collaborators in academia/industry. This mtg gave me back some optimism in an uncertain time for science.

Day 3 of #SIDSanDiego2025 included an amazing talk by PhD student Karina from @uwdermatology.bsky.social featuring our new model of #EpidermolysisBullosa Simplex. More catching up w/wonderful friends & I was truly honored to be voted onto the @siderm.bsky.social Board of Directors for a 5-year term.

Day 2 of #SIDSanDiego2025 did not disappoint! More outstanding talks, a lively poster session, and an awesome Society for Investigative Dermatology social event on the USS Midway 🛳️ 🇺🇸 @siderm.bsky.social

Amazing Day 1 of #SID2025 in San Diego! 😎 So much fun meeting up w/lab alums & collaborators @siderm.bsky.social Awesome science🔬🧫🧬at #Pachyonychia Symposium followed by an outstanding plenary talk on Hailey-Hailey disease by PhD student Jessica 🤩 @uwdermatology.bsky.social @uwmedicine.bsky.social

Congrats to Karina for taking home the 1st place poster prize 🏆 at the @uwiscrm.bsky.social Symposium. And kudos to Jessica, who gave an awesome trainee lightning⚡️talk. Proud of both our PhD students for representing the Simpson Lab @uwdermatology.bsky.social @uwmedicine.bsky.social.

This is a great 60 Minutes piece on the impact of NIH cuts on patients including those with Alzheimer’s. Great job by Kristin Weinstein from University of Washington highlighting the impacts on students (9:00). @uwmedicine.bsky.social www.cbsnews.com/news/scienti...

Incredible work from @aaandmoore.bsky.social! 🤩

Proud of Jess & Karina who won travel awards from Uplifting Athletes & UC Irvine Skin Bio Resource Ctr to present at the SID @siderm.bsky.social & PC Project mtg on their use of 3D models of #rare #genetic #skin #blistering disorders ( #HaileyHailey & #EpidermolysisBullosa) to find new therapies🤩🔬👩‍🔬🧫

Dr. Paul Nghiem, UW Derm Chair & Director @mc3-institute.bsky.social, joined leading US researchers in sounding the alarm over recent cuts & delays in NIH-funded research. The future of life-saving discoveries is on the line. @barrons.com @uwmnewsroom.bsky.social www.barrons.com/articles/nih...

Enjoyed meeting a great new crowd of scientists at the Amer Assoc for Anatomy @anatomyorg.bsky.social in Portland! Thank you to @anatomyorg.bsky.social for the invitation to share our work from @uwdermatology.bsky.social on mechanisms of #skin #blistering disease & potential new molecular therapies.

Always love the excitement of the #AAD mtg for #dermatology. But as I sit in scientific sessions, I want my clinical/industry colleagues & patient advocacy groups to know #NIH funded research was critical for delivering nearly all modern therapies we use for our patients #AAD2025 #StandUpForScience

On #RareDiseaseDay I’m proud to have 2 amazing PhD students @uwdermatology.bsky.social building organotypic models of #HaileyHailey disease & #EpidermolysisBullosa to find new therapies. Thanks to @pnrigenetics.bsky.social for hosting an outstanding symposium for clinicians, researchers & advocates.

Excited to attend #AAD2025 in Orlando next week and to lead our session on "Leveraging Teledermatology to Improve Patient Access." Mark your meeting agenda to join us on Sunday at 1:00 PM in Room W314B.

Our review on #acantholytic #skin #blistering disorders is out @thejidjournal.bsky.social. #Darier, #HaileyHailey, & #Grover dz weaken #desmosomes that hold the #epidermis together but lack any FDA-approved Tx. We summarize recent pubs pointing to new Tx strategies: www.jidonline.org/article/S002...

Let it be known that Cory gave an AMAZING talk and that you should immediately invite him to give a seminar near you! But seriously, super fun to co-host a speaker who served as a mentor to one of my former undergrads. It takes a village and we still need to remember to enjoy the good stuff.

Had an awesome visit to the other UW (Univ of Wyoming) to speak w/the Molecular Biology Dept. Great engagement w/amazing scientists--the lunch/Q&A w/postdocs & students was especially inspiring and energizing. Thank you so much for the invite @scienceguy38.bsky.social & @wyomingwormboy.bsky.social.

Your Action Is Needed! Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy www.ascb.org/science-poli...

$100k in pilot funds! Come and get it. Join us for the *free* HUB annual meeting, April 8 day before SFB. See more below.

Proud of UW med student Rafael Homer for representing @simpsonlabuw.bsky.social & UW #Dermatology at the Western Medical Research Conference in Carmel, CA. His project used our #Darier disease model to find new treatment strategies for this orphan #skin #blistering disorder. @uwmedicine.bsky.social

Was fantastic to catch up with friends/colleagues/mentors at @ascbiology.bsky.social #CellBio2024

Thanks for the invitation!

We're hiring! Funded postdoctoral position available in the Moltke Lab. 79k starting salary and access to a fellowship program in the Institute for Translational Immunology that offers both academic and industry training tracks. Details here: jobrxiv.org/job/universi...

Excited to be in sunny San Diego for #ASCB2024 #CellBio2024 @ascbiology.bsky.social