1/ Best practices for 2L+ tx #MetastaticUrothelialCarcinoma 🧵 w🌟 @tiansterzhangmd.bsky.social & me ...assuming EV+P 1L ✅FGFR3 alts: THOR/erda 🎯Trop-2: sacituzumab govitecan 🏁HER2 IHC 3+: T-DXd Support by edu grants: Astellas, Gilead Sci, Merck, Seagen #CME from @bonumce.bsky.social ℹ️👇

This GU oncology family — wonderful first #AUC3 consensus conference! @drchoueiri.bsky.social @pgrivasmdphd.bsky.social @davidaggen.bsky.social

Expanded indication for TDXd!

Happy New Year from OncoAlert @jrgralow.bsky.social @elisabettabonzano.bsky.social @stolaney1.bsky.social @stoverlab.bsky.social @pgrivasmdphd.bsky.social @axelmerseburger.bsky.social @drnataliagandur.bsky.social @biagioricciutimd.bsky.social @fernandoonco.bsky.social

Awesome panel moderated by #MontyPal #BradMcGregor for non clear cell #Kidneycancer. Histology matters! And so do molecular markers! #AUC3 @drchoueiri.bsky.social @pgrivasmdphd.bsky.social @davidaggen.bsky.social @erplimackmd.bsky.social

Redefining first-line options for advanced urothelial carcinoma! Insights on platinum chemotherapy, immunotherapy combos, and patient-tailored strategies. @tiansterzhangmd.bsky.social @oncoalert.bsky.social @oncbrothers.bsky.social #Oncology #BladderCancer

Huge kudos to the NCCN for officially incorporating prostate cancer into the Genetic/Familial High-Risk Assessment Guidelines. We've come a long way!

This Christmas and every year I remember my current and past patients with ornaments on our tree. Have been fortunate to care for thousands in my ten year career in oncology. Hope to help thousands more in the years to come. 🎄🕯️

Launching #AUC3 in Miami, consensus across kidney and bladder cancers. From small steps to significant scientific advances that change our patients’ lives. @drchoueiri.bsky.social #MontyPal #RanaMcKay #JonathanRosenberg

#BrianShuch kicks us off, local #kidneycancer heterogeneous - guppies, goldfish and sharks! Integrating staging & biomarkers to help us evaluate risk and prognosis. #AUC3

Drs. #NaomiHaas #HansHammers debate locally advanced #kidneycancer and use of periop immunotherapy. Grading, staging, and prediction of risk/benefit leads to rigorous shared decision making with our patients. @drchoueiri.bsky.social #AUC3

#BrianRini & #MikeAtkins debate refractory #kidneycancer management after IO front line or adjuvant PD1 inhibitor. Do we rechallenge? Yes likely after a certain time point (6 vs 12 months debated). #AUC3

Great milestone 🎯🥇 for #mCRC treatment #GIonc #OncSky based on the last update clinicaltrials.gov/study/NCT046... FDA grants Accelerated Approval to Encorafenib Plus Cetuximab and Chemo for BRAF V600E+ Metastatic Colorectal Cancer www.fda.gov/drugs/resour...

🔍 Does AI reduce #clinician workload? @NEJM study on @NuanceDragon DAX Copilot, an AI-powered documentation tool, found minimal impact on EHR efficiency & financial metrics❗️ 💡AI tools need to be developed in comjuction with 🩺🥼🧑‍⚕️ not in silos #AIinMedicine #LLMs @oncoalert.bsky.social

Congratulations @n8pennell.bsky.social and all elected members @ascocancer.bsky.social

“Why are we listening to men & not women?” asks Dr @narjustflorezmd.bsky.social of @florezlab.bsky.social This question & the increase in #lungcancer diagnoses among younger women vs men are the genesis for the #HearHer campaign. Read more & help us change this👇 healio.com/news/hematolog…#LCSMSM

Interesting article studying oncologist’s decision-making from a psychosocial perspective: #Oncologists exposed to scenarios of a “nice” or “demanding” pt were associated with less recommendations of chemotherapy near the #EOL . #heme/onc #lcsm #lcam #oncsky #medsky doi.org/10.1093/onco...

Key takeaways: •The #HearHer campaign focuses on gender disparities in lung cancer diagnosis and clinical trial enrollment. •Clinicians should take women’s concerns seriously and make use of imaging for early detection. Article here: www.healio.com/news/hematol...

🧵 Real world effectiveness study using #EHR from 20 health systems: #COVID19 vaccination ⬇️ risk of #longCOVID in kids/adolescents during Delta & Omicron waves. Mediation analysis suggests effectiveness is indirect, via ⬇️ the risk of #SARSCoV2 infection. #MedTwitter #MedSky

Link to the original study examining real world effectiveness of #COVID19 vaccination in reducing risk of #LongCovid in kids & adolescents here: www.thelancet.com/action/showP.... #MedSky #IDSky #Pediatrics #GetVaccinated

Stayed active during 17-hour flight from SEA->Singapore :-) Looking forward to present TROPiCS04 phase 3 trial data at #ESMOASIA on Dec 7 ~10am local time discussed by Dr. Friedlander @oncoalert.bsky.social @achoud72.bsky.social @erplimackmd.bsky.social @valdesan.bsky.social @fredhutch.bsky.social

Thank you Mirrors of Medicine & dear Colleagues #PROSCA24 #BLADDR24 & #RENALC24 FINAL STATS with OVER 21 million impression on X SHOUT OUT TO Our Ambassadors Specially @drnataliagandur.bsky.social @barbaramelao.bsky.social @pgrivasmdphd.bsky.social @achoud72.bsky.social

As we return from Thanksgiving Holidays we are grateful for everyone’s hard work & @ASCO mission to support providers & patients! Would like to remind active members to participate in @ASCO election-stellar candidates across all categories-Deadline: Dec 3rd 3pm EST society.asco.org/about-asco/a...

“The effectiveness of telehealth in delivering psychosocial, nutritional, and physical activity support highlights its potential to improve patient outcomes and overcome barriers to care” @pallonccop.bsky.social #oncsky ascopubs.org/doi/10.1200/...

#PROSCA24 ✨PSMA is the imaging choice in BCR ✨impact on clinical management ~60% ✨PPV 85-90% ✨different PSMA tracers with different detection rate ✨PROMISE registry to build monogram to predict survival: in BCR setting the nomogram had a strong correlation with survival ‼️for MDT: use PSMA11

Impact of cycle 1 irAEs on ICI outcomes: - 683pts from SWOG DART trial - g1-2 irAEs = ⬆️OS HR 0.61 p < 0.001 - g3+ irAEs = ⬇️OS HR  1.41 p= .025 - g1-2 derm irAE = ⬆️OS v other g1-2 irAE HR 0.67 p=0.002 Congrats @eladsharonmd.bsky.social @oncoalert.bsky.social academic.oup.com/jnci/advance...

Do systemic responses to ICI (eg irAEs) associate w outcomes? Nice use of existing basket studies by @pateloncology.bsky.social @eladsharonmd.bsky.social Razelle Kurzrock et al

Thank you Mirrors of Medicine & dear Colleagues #PROSCA24 #BLADDR24 & #RENALC24 have just concluded with OVER 20 million impression on X SHOUT OUT TO Our Ambassadors Specially @drnataliagandur.bsky.social @barbaramelao.bsky.social @pgrivasmdphd.bsky.social @achoud72.bsky.social

Join Drs. Gillessen, Omlin, Castro, Zilli, Tombel & Turco as they discuss Advanced Prostate Cancer Consensus Conference 2024, presentation at #PROSCA24 #ProstateCancer https://buff.ly/3B5902t @drnataliagandur.bsky.social @barbaramelao.bsky.social @achoud72.bsky.social @pgrivasmdphd.bsky.social

Good job Team #DiagnoseAndTreats! Keep up the donations, #OncSky, #RadSky, #PathSky, #RadOnc, #OncoAlert! We are your multi-d cancer fighting team for #HCWvsHunger 2024!

⭐️Pancreatic Cancer Surge May Be Less Worrisome Than It Seemed A rise in the disease in younger people was not followed by an increase in deaths, a study found, and might be a sign of overdiagnosis @nytimes.com www.nytimes.com/2024/11/18/h...

🥁🥁🥁Super honored to host a JAMA Oncology podcast with the one & only giant of leukemia, Dr. Hagop Kantarjian 🎙️ Listen to a tour de force of all therapies in CML. ⭐️CML is the poster child for precision oncology Link: edhub.ama-assn.org/jn-learning/...

⭐️Development and phenotype of regulatory T cells This picture is worth 100 K words! Link to pdf: www.stemcell.com/media/files/...

⭐️Nice review @theaacr.bsky.social journal Cancer Discovery 👉🏼The Journey of Antibody-Drug Conjugates: Lessons Learned from 40 Years of Development @ptarantinomd.bsky.social bit.ly/3YZn7OK

Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer www.nejm.org/doi/full/10....

🍁Grateful hearts, joyful gatherings, and one filled with love and laughter. Wishing you all a blessed and bountiful Thanksgiving. 🍁🦃 #Thankful #Gratitude #HappyThanksgiving   #thanksgiving2024 #Thanksgiving  #Thanksgiving24 #oncsky #medsky

Friends, help us feed folks via #HCWvsHunger! Donate to any local food bank (find one https://buff.ly/2EhMZ28) or hunger org, 📸 your receipt, & log it for your fave #MedTwitter or #MedSky team at HCWvsHunger.org by 12/3. FAQs there too!

⭐️Association of Antibody–Drug Conjugate (ADC) Target Expression and Interstitial Lung Disease (ILD) in Non-Small-Cell Lung Cancer (NSCLC): Association or Causation or Neither? Nice work spearheaded by @adesaimd.bsky.social mdpi.com/3031120

The Efficacy and Safety of Mirvetuximab Soravtansine in FRα-Positive, Third-Line and Later, Recurrent Platinum-Sensitive Ovarian Cancer: The Single-Arm Phase 2 PICCOLO Trial - Annals of Oncology www.annalsofoncology.org/article/S092...

PEACE-1 published Radiotherapy of the prostate in metastatic pts prevents serious GU complications, in pts with low and high tumor burden How to select patients? - all ? - based on live expectancy ? - response to systemic Tx ? - prostate volume ? www.thelancet.com/journals/lan...

Thanks @achoud72.bsky.social for the tips! Amazing meetings in Vienna: #PROSCA24 #BLADDR #RENALC @oncoalert.bsky.social Learning from & interacting with friends/colleagues! @fredhutch.bsky.social @erplimackmd.bsky.social @jrgralow.bsky.social @glaucomflecken.bsky.social @johngoremd.bsky.social

This is my 1st post in BlueSky wishing Happy Thanksgiving to everyone with health! Best wishes from Vienna! @erplimackmd.bsky.social @achoud72.bsky.social @lauracaba.bsky.social @oncoalert.bsky.social @johngoremd.bsky.social @drnataliagandur.bsky.social @fredhutch.bsky.social @tmprowell.bsky.social