The innate immune protein calprotectin ablates the bactericidal activity of β-lactam antibiotics

What's Hot This Year in ID Clinical Science 2025 ✅ Just Accepted 🔗 https://bit.ly/4t0iXEH

Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...

I feel seen

Can’t wait to see the discoveries that are going to come out of the Reyes Ruiz Lab! Such a great scientist and mentor!

New review article on management of S. aureus bacteraemia: jamanetwork.com/journals/jam... @jama.com @vancefowler.bsky.social #IDSky Check out the gorgeous Figure which brings together elements of pathogenesis and management: (thread)

Such a wonderful day celebrating all that has been accomplished by the Skaar lab over the last 20 years! I feel very lucky and proud to be a part of such an incredible group of scientists!

Thanks @contagionlive.bsky.social for the opportunity to highlight some of the hot ID topics from 2024 that we covered in our recent review: doi.org/10.1093/cid/... Always great to be able to talk about all that is going on in ID!

Part 3 w/ Dr. @jefffreiberg.bsky.social takeaways: -SABATO Trial shows oral antibiotics can replace IV for certain S aureus cases. -Mupirocin still tops iodine for MRSA decolonization, but rising resistance is a concern. #IDsky #MEDsky Listen here: www.contagionlive.com/view/2024-s-...

Part 2 w/ Dr. @jefffreiberg.bsky.social, he discussed some findings from 2024 on the rise of AMR in #UTIs. From trials of cefepime-taniborbactam to the potential of gepotidacin, some of the challenges and future of #UTI treatment. #IDsky #MEDsky Listen here: www.contagionlive.com/view/antibio...

In Part 1 of our conversation with Dr. Jeffrey Freiberg from Vanderbilt University Medical Center, we dive into the rising concerns of emerging infections, including #dengue, #mpox, #measles, and #H5N1 influenza. #IDsky #MEDsky Stay tuned for Part 2 next week: www.contagionlive.com/view/emergin...

Another year of incredible advances in ID! Our review hardly does justice to everything accomplished last year. Fortunate to have had the opportunity to write this review, but even more fortunate to be part of a field working so hard for the good of so many. ID is needed now as much as ever! #IDSky

Does anyone know of a lab that will run dalbavancin levels? #IDSky

The study protocol for STOP-Vanc, our RCT looking at the use of MRSA nares PCR testing in an ICU, is finally published! We are hoping to be done with enrollment soon and excited to see what we learn from this study! #IDSky #MedSky trialsjournal.biomedcentral.com/articles/10....

Very interesting analysis of the opportunity cost of doing an MD-PhD. At the end of the day the choice should be about the type of career you want to have. I have not regretted my choice to get an MD-PhD one bit because it has set me on the perfect path for what I want my career to be!

Bactericidal antibiotics release bacterial DNA that activates TLR9, while static antibiotics do not. This can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics to prescribe? Amazing work by Julia Gross and collaboration with Iain Fraser! rdcu.be/d1Phk

Staph papers @staph-papers.bsky.social is now on Bluesky!