In the first few days after the update, our users unwillingly uncovered some bugs that slipped through our internal testing schemes. Everything that led to crashes in the last week is fixed now.

I am delighted to announce our newest update of our tools.helmholtz-hips.de/structman/ webserver. Highlights of the newest update: - Inclusion of the AlphaFold DB collaboration datasets - Addition of MSAs to StructMAn outputs - Addition of predicted complex structures

Information Leakage in Enzyme Substrate Prediction https://www.biorxiv.org/content/10.64898/2026.02.26.708291v1

We are happy to present a piece of analysis that I consider to have a major impact on our understanding of how good variant effect prediction (VEP) tools really are: www.biorxiv.org/content/10.6....

🧬🖥️ Call for Abstracts OPEN! Join us in celebrating 40 years of the German Conference on #Bioinformatics (#GCB2026) 🎉 📍 Saarbrücken | 🗓 22–25 Sep 2026 Submit your research & shape the future of Bioinformatics! Deadlines Workshops: 31 Mar 26 Talks: 3 May 26 Poster: 6 Aug 26 👉 GCB2026.DE

StructGuy: Data leakage free prediction of functional effects of genetic variants. https://www.biorxiv.org/content/10.64898/2025.12.01.691563v1

We are excited that our paper "Cleanifier: Contamination removal from microbial sequences using spaced seeds of a human pangenome index" is now published at Bioinformatics (doi.org/10.1093/bioi...). You can find it at gitlab (gitlab.com/rahmannlab/c...) or install it via PyPI or Bioconda.

Detection of alternative splicing: deep sequencing or deep learning? https://www.biorxiv.org/content/10.1101/2025.08.23.671909v1

SingleRust: A High-Performance Toolkit for Single-Cell Data Analysis at Scale https://www.biorxiv.org/content/10.1101/2025.08.04.668429v1

Our preprint is finally out for SingleRust: doi.org/10.1101/2025... Stay tuned: @singlerust.bsky.social, @ianfd.bsky.social github.com/SingleRust

What an exciting week it's been at the #ISMBECCB2025 conference! The Drug Bioinformatics group had a fantastic presence, with six members presenting their latest work across various COSIs. www.linkedin.com/feed/update/...

This week I presented DataSAIL at the #ISMBECCB2025 conference in #Liverpool It has been an amazing chance and experience to meet many people working on information leakage. And getting great ideas to extend it Nicely supervised by & colaborated with @dbblumenthal.bsky.social @ok55991.bsky.social

I am very excited to share the publication of our tool StructMAn 2.0 in the NAR webserver issue (10.1093/nar/gkaf381). If you want to annotate protein structures to protein sequences or if you are looking for structural evidence for PPIs, consider using: tools.helmholtz-hips.de/structman/

DataSAIL is out in @naturecomms.bsky.social Since the preprint, we have improved the work a lot, thanks to countless reviewers and feedback. You can find it here: nature.com/articles/s41... Thanks, @dbblumenthal.bsky.social and @ok55991.bsky.social, for helping and supervising me on this journey.