Temurkhan Ayupov
@timayupov.bsky.social
📤 24
📥 29
📝 7
Group Leader at IOB
https://www.linkedin.com/in/temurkhan-ayupov
reposted by
Temurkhan Ayupov
IOB - Institute of Molecular and Clinical Ophthalmology Basel
11 days ago
🚀 Warm congratulations to
@timayupov.bsky.social
, appointed Group Leader at IOB. The new Mitochondrial Biology and Therapy Group studies mitochondrial dysfunction in neurodegeneration and develops targeted mitochondrial therapies using MitoCatch.
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reposted by
Temurkhan Ayupov
Nature Reviews Molecular Cell Biology
28 days ago
New Online! Programmable delivery of mitochondria to specific cell types
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Programmable delivery of mitochondria to specific cell types
Nature Reviews Molecular Cell Biology, Published online: 09 June 2026; doi:10.1038/s41580-026-00986-wIn this Tools of the Trade article, Ayupov (Roska lab) describes the development of MitoCatch, a method to display protein binders on the mitochondrial surface to facilitate cell-type-specific targeting during mitochondrial transplantation.
http://dlvr.it/TSy0vS
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reposted by
Temurkhan Ayupov
Catalina Vasilescu, PhD
3 months ago
Last 2 weeks of research on
#Mitochondria
in
#Health
and
#Disease
! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
Among highlights 👇
www.nature.com/articles/s41...
@biomednews.bsky.social
@gavinmcstay.bsky.social
@mitoscientist.bsky.social
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Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature
MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.
https://www.nature.com/articles/s41586-026-10391-0
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reposted by
Temurkhan Ayupov
Nature
3 months ago
A system of protein binders directs energy-generating organelles to targeted cells, potentially improving ways to treat mitochondrial dysfunction
go.nature.com/42bk2wX
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Therapeutic mitochondria transplants made more efficient with targeting tool
A system of protein binders directs energy-generating organelles to targeted cells, potentially improving ways to treat mitochondrial dysfunction.
https://go.nature.com/42bk2wX
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reposted by
Temurkhan Ayupov
Nature
3 months ago
Nature research paper: Cell-type-targeted mitochondrial transplantation rescues cell degeneration
go.nature.com/4thFlZM
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Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature
MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.
https://go.nature.com/4thFlZM
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reposted by
Temurkhan Ayupov
Nature Biotechnology
3 months ago
The mitochondrion-targeting tool MitoCatch brings mitochondria into specific cell types through cell-surface-targeted binders
#NBThighlight
www.nature.com/articles/s41...
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Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature
MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.
https://www.nature.com/articles/s41586-026-10391-0
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Excited to share that our technology for cell-type-targeted mitochondrial delivery is published in @Nature
www.nature.com/articles/s41...
In this work, we introduce MitoCatch, a platform that enables programmable, targeted delivery of donor mitochondria to specific cell types. (1/7)
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Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature
MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.
https://www.nature.com/articles/s41586-026-10391-0
3 months ago
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reposted by
Temurkhan Ayupov
Georg Kosche
10 months ago
Gene editing of single, targeted neurons in vivo is now feasible. We are proud to present our preprint for highly efficient single-cell electroporation using RNA. With
@alex-fratzl.bsky.social
,
@munzlab.bsky.social
, Botond Roska
@iobswiss.bsky.social
#neuroskyence
www.biorxiv.org/content/10.1...
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In vivo single-cell gene editing using RNA electroporation reveals sequential adaptation of cortical neurons to excitatory-inhibitory imbalance
The balance between excitatory and inhibitory neurotransmission is fundamental for normal brain function, yet the adaptation of individual neurons to disrupted excitatory-inhibitory balance is not wel...
https://www.biorxiv.org/content/10.1101/2025.09.13.672380v1
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reposted by
Temurkhan Ayupov
Georg Kosche
10 months ago
Single-cell electroporation is performed via patch pipette and under 2-photon visual guidance in vivo. A short voltage pulse train is applied through the pipette to deliver RNA molecules into a targeted cell. The video below shows this process in cortical neurons expressing GCaMP6s.
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reposted by
Temurkhan Ayupov
IOB - Institute of Molecular and Clinical Ophthalmology Basel
about 1 year ago
🧬👁️Discover how research and patient care come together in the latest Novartis Live magazine — with stories from the labs and clinics shaping the future of vision. 🔗
bit.ly/4km6XZ0
#IOB
#VisionScience
#TranslationalResearch
#Basel
#Ophthalmology
#AcademicSky
#Novartis
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reposted by
Temurkhan Ayupov
Tamas Dalmay
over 1 year ago
How do different sensory signals combine in the computation of cognitive maps? I’m thrilled to share our new preprint, in which we investigate this question in the context of the head-direction system:
www.biorxiv.org/content/10.1...
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Joint visual-vestibular computation of head direction and reflexive eye movement
Several cognitive maps have been identified, but what sensory signals drive them and how these are combined are not well understood. One such map, the head-direction representation, is believed to be ...
https://www.biorxiv.org/content/10.1101/2025.02.11.637650v1
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reposted by
Temurkhan Ayupov
IOB - Institute of Molecular and Clinical Ophthalmology Basel
over 1 year ago
✨Thrilled about our new publication in Nature Medicine! We are excited to offer a potential new avenue for treating Stargardt disease! Read the paper here:
nature.com/articles/s41...
Watch the video:
iob.ch/fileadmin/ge...
Press release here:
iob.ch/news-view-al...
© 2025 IOB
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reposted by
Temurkhan Ayupov
IOB - Institute of Molecular and Clinical Ophthalmology Basel
over 1 year ago
We are pleased to share that RhyGaze, IOB's first spin-off, has secured Series A funding with an USD 86 million investment to advance vision restoration therapy. Read more:
iob.ch/news-view-al...
#Biotech
#Basel
#Innovation
#LifeSciences
#GeneTherapy
#Ophthalmology
#RhyGaze
#BioTechHub
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