🕵️‍♀️ In this cancer Clue game: 🧬 Victim: CSCs 🔪 Weapon: Nifuroxazide 🎯 Mode: DNA crosslinks + STAT3 block 🧬 Scene: PARPi-resistant breast cancer From the Charafe/Ginestier team @CRCM 🔗 pubmed.ncbi.nlm.nih.gov/40038300/ ✍️ by @celiarouault.bsky.social 🔗 communities.springernature.com/posts/unveil...

Sometimes, conducting research feels like a police investigation! Discover the parallel between our article: Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer and police enquiry communities.springernature.com/posts/unveil... @cginestier.bsky.social

Cells control the supply of new histones to chromatin by blocking histone chaperone function - see here how Codanin-1 sequesters 4 ASF1 molecules.

Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇

Glad to have contributed to this beautiful work led by @celiarouault.bsky.social & colleagues at @crcm.bsky.social just out in @naturecomms.bsky.social. Using drug repurposing, they unveiled the STAT3/FanA axis as a targetable vulnerability in breast cancer stem cells www.nature.com/articles/s41...

I am thrilled to share my first paper published in @naturecomms.bsky.social, Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARPi in breast cancer @Christophe Ginestier @emmanuellecharafe.bsky.social I thanks all the collaborators and supporters rdcu.be/ecaao

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

Check out our (@vindignilab.bsky.social) Spotlight article highlighting @durocher1.bsky.social group's discovery of synthetic lethal SMARCAL1-FANCM interaction, revealing a novel genetic buffering mechanism for genome stability at simple repeat regions during replication www.cell.com/trends/genet...