In the PROMIZING trial, proportional-assist ventilation with load-adjustable gain factors did not differ significantly from pressure-support ventilation with respect to the time to liberation from mechanical ventilation. Full trial results and Research Summary: nej.md/4kC2a67 #MedSky #PulmSky

For participants with overweight or obesity, the efficacy and safety of oral semaglutide at a dose of 25 mg once daily for weight management are unclear. Research findings from the OASIS 4 phase 3 trial are summarized in a new Quick Take video. nej.md/4prULZO #MedSky #EndoSky

A 30-year-old woman presented with a 10-week history of painful skin nodules and a 6-week history of fevers and night sweats. A physical examination was notable for palpable subcutaneous nodules with overlying erythema. Read the full case details: nej.md/3V9xwWA #MedSky #DermSky

In the ACHIEVE-1 phase 3 trial, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes. Full trial results and Research Summary: nej.md/4ngEZ36 #MedSky #EndoSky

In critically ill patients, whether proportional-assist ventilation results in a shorter duration of mechanical ventilation than pressure-support ventilation is unclear. Research findings from the PROMIZING trial are summarized in a new Quick Take video. nej.md/3K4mK1C #MedSky #PulmSky

Since the emergence of clade Ib mpox, spread across Africa has been occurring. In this report, spread into the Republic of the Congo is described. Read the full report: nej.md/469giz4 #MedSky #IDSky #GlobalHealth

In patients with localized colorectal cancer and PIK3CA hotspot mutations in exon 9 or 20, daily low-dose aspirin resulted in a significantly lower recurrence rate than placebo. Full ALASCCA phase 3 trial results and Research Summary: nej.md/4mpKXNp #MedSky #Oncology

Orforglipron is an oral, small-molecule, nonpeptide glucagon-like peptide-1 (GLP-1) receptor agonist being evaluated for the treatment of type 2 diabetes. Research findings from the ACHIEVE-1 phase 3 trial are summarized in a new Quick Take video. nej.md/42tGbHh

Case Record of the MGH: An 11-year-old girl with eczema was evaluated for chest pain and arm pain. Imaging showed multiple bone and liver lesions. The erythrocyte sedimentation rate was higher than 130 mm per hour. A diagnosis was made. Read the full case details: nej.md/466v9Ku #MedSky

Weekend Briefing for September 20, 2025: New Images in Clinical Medicine: Systemic Mastocytosis nej.md/46eCt72 Three New Perspectives: 1️⃣ Structural and Scientific Racism, Science, and Health nej.md/4mn1K3C #MedSky

A 15yo with acne vulgaris presented to the dermatology clinic with a 2-week history of a progressively worsening painful, blistering rash on both hands. One week before the onset of the rash, she had started treatment for her acne. What is the most likely diagnosis? nej.md/IC09182025

𝐒𝐢𝐧𝐠𝐥𝐞-𝐧𝐮𝐜𝐥𝐞𝐨𝐭𝐢𝐝𝐞 𝐩𝐨𝐥𝐲𝐦𝐨𝐫𝐩𝐡𝐢𝐬𝐦 (𝐒𝐍𝐏) is a type of variation affecting a single nucleotide in a DNA sequence, in which the nucleotide (for example, cytosine) is substituted with a different type of nucleotide (for example, thymidine). #ScienceSky #Genetics

Tumor lysis syndrome has evolved and become less predictable with the introduction of new cancer therapies. A new review explores risk factors and causes of the syndrome, as well as strategies for treatment and prevention. Learn more: nej.md/4plR9sh #MedSky #Oncology

What are win ratios? And what do they have to do with ordering a cappuccino? ☕ Find out in a new Stats, STAT! animated video from NEJM Evidence: youtu.be/jKtFTk2ASIA #MedSky

In the OASIS 4 phase 3 trial, once-daily oral semaglutide at a dose of 25 mg resulted in a greater mean reduction in body weight than placebo in participants with overweight or obesity. Full trial results: nej.md/4nFVWmZ #MedSky #EndoSky

New in the September 18, 2025, issue of NEJM: Aspirin for PI3K-Altered Localized Colorectal Cancer (ALASCCA phase 3 trial) nej.md/4mpKXNp Orforglipron in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial) nej.md/4ngEZ36 #MedSky

In patients with localized colorectal cancer and PIK3CA hotspot mutations in exon 9 or 20, daily low-dose aspirin resulted in a significantly lower recurrence rate than placebo. ALASCCA phase 3 trial results: nej.md/4mpKXNp #MedSky #Oncology

RSV remains a severe infection in infants and children. In this report, data on the activity of clesrovimab, a long-lasting RSV monoclonal antibody, are described as compared with palivizumab. Full interim results for the SMART phase 3 trial: nej.md/4poVkDE #MedSky #IDSky #PedSky

Clesrovimab is a long-acting monoclonal antibody against respiratory syncytial virus fusion protein. In the CLEVER phase 3 trial involving 3614 healthy infants, clesrovimab reduced RSV disease and associated hospitalization. Full trial results: nej.md/48jpBO4 #MedSky #IDSky #PedSky

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxic effects. Full study results: nej.md/42u4eWF

A retrospective cohort study involving children born between 1996 and 2016 suggests a significant but small associated increased risk of hematologic cancer among those exposed to radiation from medical imaging. Full study results: nej.md/41YXEHD #MedSky #Oncology

In older adults with impaired physical performance after MI, multidomain rehabilitation reduced cardiovascular death or unplanned hospitalization at 1 year, with no serious adverse effects. Full PIpELINe trial results and Research Summary: nej.md/4fRsuYh #MedSky #CardioSky

A 16-year-old girl presented with a 2-month history of cough. Chest radiography showed a well-circumscribed cystic lesion containing another rounded structure, creating a double-domed appearance, at the base of the left lung. Read the full case details: nej.md/41OoFgS #MedSky #PulmSky

New AI Grand Rounds! Dr. Karandeep Singh explains how early experiments with code led him to biomedical informatics, why gaps between paper performance and clinical reality must be confronted, and how governance committees weigh ethics and safety. Listen to the full episode: nejm.ai/ep34

MAPLE-HCM trial: In patients with symptomatic obstructive hypertrophic cardiomyopathy, whether aficamten monotherapy provides greater clinical benefit than monotherapy with the beta-blocker metoprolol is unknown. Research findings are summarized in a new Quick Take video. nej.md/4mWDx5n

Presented at #EASD2025: In the ATTAIN-1 phase 3 trial, the use of orforglipron, an oral GLP-1 receptor agonist, led to significant mean body-weight reductions in patients with obesity, as compared with placebo. Full trial results: nej.md/4n1nSl2 @easdnews.bsky.social

In a 93-year-old woman with a history of aortic stenosis who was evaluated for dyspnea, transthoracic echocardiography (shown in videos) was used to assess for progression of aortic stenosis. Read the full case details: nej.md/4nnSjSb #MedSky

A 5-year-old boy with IgA vasculitis presented with scrotal swelling and pain and worsening of his leg rash. The physical examination showed purpura on the legs and swelling, erythema, and tenderness of the right scrotum. Read the full case details: nej.md/4m4UJV0 #MedSky

Presented at #ANA2025: In patients with idiopathic normal-pressure hydrocephalus responsive to CSF drainage, shunting improved gait and balance at 3 months, but not cognition or incontinence, and was associated with some procedure-related risks. Full PENS trial results: nej.md/41OfPQ5

In patients with nonobstructive HCM, mavacamten did not significantly improve peak oxygen uptake or decrease symptoms as compared with placebo, and more patients had a reduction in LVEF with mavacamten. Full ODYSSEY-HCM phase 3 trial results and Research Summary: nej.md/4oSZx2m #MedSky

“The insights of Görlich, McKnight, and their colleagues are being harnessed in medical research.” 🧪 Read how low-complexity domains of proteins impact human health in @nejm.org #LaskerAward #Lasker2025 @mpi-nat.bsky.social #phaseseparation #biophysics www.nejm.org/doi/full/10....

“For physician–scientists conducting early clinical trials, the results could best be described as miraculous.” 🧪 2025 #LaskerAward winners M. Welsh, J. González, & P. Negulescu developed life-saving #cysticfibrosis treatments. @nejm.org #Lasker2025

Rohan Khazanchi, MD, MPH, who coauthored a recent Medicine and Society article on race-based PFTs, discusses their financial implications and their adverse consequences. Read the article and watch the full video podcast with host Harleen Marwah, MD: nej.md/4kYkaH6

A 42-year-old man presented with an expanding, asymptomatic rash on his trunk. Examination showed multiple papulosquamous plaques on the torso and a larger patch with central clearing and peripheral scaling on the left side. Read the full case details: nej.md/4m9mawS #MedSky #DermSky

In symptomatic obstructive hypertrophic cardiomyopathy, aficamten improved oxygen uptake and heart function and decreased symptoms more than metoprolol, with a similar incidence of adverse events. Full MAPLE-HCM phase 3 trial results and Research Summary: nej.md/45zDWo3 #MedSky #CardioSky

ODYSSEY-HCM phase 3 trial: Mavacamten is approved to treat patients with symptomatic obstructive hypertrophic cardiomyopathy, but its clinical effects in nonobstructive hypertrophic cardiomyopathy are unclear. Research findings are summarized in a new Quick Take video. nej.md/47TMwQb #MedSky

Case Record of the Massachusetts General Hospital: A 93-year-old woman was evaluated by her primary care physician because of dyspnea. She had a history of aortic stenosis and atrial fibrillation and flutter. A diagnosis was made. Read the full case details: nej.md/4nnSjSb #MedSky

PIpELINe trial: Older patients with myocardial infarction have a higher incidence of recurrence, unplanned hospitalization, and death than younger adults. Research findings on a cardiac rehabilitation intervention are summarized in a Quick Take video. nej.md/4pfqFZB #MedSky #CardioSky

Weekend Briefing for September 13, 2025: 🆕 Images in Clinical Medicine: Subcutaneous Panniculitis-like T-Cell Lymphoma nej.md/3V9xwWA 🚭 New Editorial: Reducing Tobacco Use Worldwide — A New Perspective Series nej.md/4nmoPEn

A 44-year-old man presented with a 4-day history of an itchy rash and a 2-day history of fever and malaise. The rash had first appeared on the scalp and then spread across the body within 24 hours. What is the most likely diagnosis? nej.md/IC09112025 #MedSky #DermSky

𝐈𝐦𝐦𝐮𝐧𝐨𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐢𝐨𝐧 is the inhibition of unwanted immune responses that, in the context of allo-transplantation, would otherwise result in the rejection of a foreign (or histoincompatible) organ or cellular graft. Full definition of this NEJM Illustrated Glossary term: nej.md/469UKAY #ScienceSky

Intramyocardial hemorrhage following primary PCI is a major predictor of adverse cardiovascular outcomes but is difficult to diagnose in real time. In NEJM Evidence, Vora et al. describe the use of post-PCI troponin kinetics to make the diagnosis. Full study results: eviden.cc/47FEcTI #MedSky

Three videos show echocardiography in a woman who presented with acute pain, swelling, and bruising on the upper portion of her left knee after using an electronic massage gun. Read the full case details: nej.md/3HHMwrP #MedSky

New in the September 11, 2025, issue of NEJM: Aficamten or Metoprolol for Hypertrophic Cardiomyopathy (MAPLE-HCM phase 3 trial) nej.md/45zDWo3 Mavacamten in Nonobstructive Hypertrophic Cardiomyopathy (ODYSSEY-HCM phase 3 trial) nej.md/4oSZx2m #MedSky

Drs. Michael Welsh, Jesús González, and Paul Negulescu have won the 2025 Lasker–DeBakey Clinical Medical Research Award for their roles in developing treatments for cystic fibrosis. Learn more: nej.md/41L3UCI #MedSky #PulmSky #Genetics

Drs. Dirk Görlich and Steven McKnight have won the 2025 Albert Lasker Award for Basic Medical Research for showing that low-complexity domains of proteins lack structure on their own and yet can form assembled states essential to cellular functions. nej.md/4nnvn5K @stjuderesearch.bsky.social

Receipt of MOUD in jail was associated with a greater likelihood of postrelease MOUD initiation and lower risks of overdose, death, and reincarceration than no receipt of MOUD in jail. Read the Special Article: nej.md/3KdXhTf #MedSky #Psychiatry #PublicHealth

In 2024, Marburg virus disease was detected in Rwanda. A large-scale public health response was able to control the outbreak. Ultimately, 66 laboratory-confirmed cases were identified, largely in two urban hospitals. Full study from the Rwanda MVD Outbreak Response Team: nej.md/3VIaMNA

💡 New NEJM Group publication co-authored by Robert Blendon explores debates around federal funding for health and medical research for major universities in the U.S. www.nejm.org/doi/full/10....

Videos show echocardiography in a woman who died of an acute febrile illness with severe myocardial dysfunction. A novel thogotovirus, named the Oz virus, was identified in the myocardial tissue. Read the full case details: nej.md/427C7wg #MedSky #CardioSky #IDSky