👀 Looking for #mechanisticinsight beyond traditional biochemistry? Our EI-FLEX system reveals in-solution dynamics, kinetics & rare events with intuitive software that delivers publication-ready plots and clear interpretation in minutes. No biophysics expertise needed 💪> buff.ly/FTlfZgO

Want to add fast, solution-based #single-molecule dynamics to your workflow? Our new, practical handbook shows how confocal #smFRET reveals conformational change, heterogeneity & nanoscale distances, with clear, step-by-step guidance from basics to advanced analysis > buff.ly/xHefIrP

📢 Structural biochemists: do you have beautiful, atomic-resolution static structures, but feel like a piece of the puzzle is missing? Add single-molecule dynamics with smFRET to reveal hidden conformational changes 👉 excitinginstruments.com/resource-lib... #structuralbiology #proteindynamics

🇺🇸 Are you in #SanFrancisco this week for #JPM26, or local to the area, and curious to learn more about the power of high-throughput single-molecule characterisation? Drop @timcraggs.bsky.social or @robertbell.bsky.social a DM if you'd like to meet up to learn more!

Special thanks also to the @ei-science.bsky.social team for equipping us with #fcs capabilities in @ybri-uoy.bsky.social & @york.ac.uk thanks to support from EPSRC! @uoyopenres.bsky.social

Biology happens when molecules interact - in solution, in motion, in fleeting moments. Freely diffusing smFRET captures these dynamics with nanometre precision. Our new practical #smFRET handbook distils principles & analysis for confident, in-solution data. 📘 buff.ly/AgGQCLY #singlemolecule

Complementing your single-molecule immobilised assays with in-solution measurements can offer physiological relevance, fewer artefacts, seamless workflows, and richer dynamics. See how Chadda et al. used in-solution methods on the EI-FLEX to resolve conflicting FRET models 👇 buff.ly/LXkkNNy

🇺🇸 We're in beautiful #SanFrancisco next week (Mon-Thurs) to meet with investors and customers. If you're in the area, we’d love to connect to discuss the power of in-solution #single-molecule techniques and our Exciting plans for 2026. Email [email protected] to let us know.

🚀 The future of #biotherapeutic screening is here: same-day, benchtop discovery with single-molecule sensitivity. LLNL’s preprint shows how CFPS + FCS on the EI-FLEX collapses expression → binding into 1 day. Faster than SPR’s 2–7 days. Learn more - buff.ly/70yAkZF #spr #fcs #cfps

🔎 Cryo-EM reveals stunning structures and partners perfectly with dynamic single-molecule methods to link structure to motion, uncover rare states, validate flexible regions, and map conformational changes. Get in touch to learn more - buff.ly/ncBOTrM #biochemistry #structuralbiology

🙌 What - an - Exciting - year! Thank you to everyone who has supported us throughout 2025 - it has enabled us to dream big, turn those dreams into action, bring our mission to life, and ultimately achieve all of the Exciting progress we've made. 🥂🎄🌟 Have a wonderful festive break. Here's to 2026!

Curious how single-molecule tools are transforming our understanding of DNA? Chadda et al. used smFRET and DEER to reveal that RPA partially wraps single-stranded DNA instead of simply stretching it - academic.oup.com/nar/article/... #DNA #smFRET #molecularbiology #proteinDNAinteractions

smFRET tracks one molecule at a time to reveal real low/high-FRET populations, dynamic transitions, and nanoscale changes that traditional FRET masks. Learn more - bit.ly/44TVTwy #smFRET #biophysics #singlemolecule

⏰ What if your experimental workflow went from weeks to minutes? @shenk0128.bsky.social shares how solution-based measurements complement TIRF: ✓ Faster results ✓ Fewer artefacts ✓ No tethering needed ✓ Proteins stay in their native, comfortable state #singlemolecule #TIRF #proteinstructure

In this month's newsletter: a big RNA breakthrough, the power of combining structural data with dynamics, getting super fast answers to your biological questions, and some fantastic PhD opportunities. Register - fwfh6.share-eu1.hsforms.com/2tB-S9AikSdG... #rna #structuralbiology #singlemolecule

👋 Calling all Prague-based structural biologists and single-molecule enthusiasts! You are invited to listen and learn from @timcraggs.bsky.social on 9 Dec at the J. Heyrovský Institute of Physical Chemistry - www.jh-inst.cas.cz/seminar/tim-... #singlemolecule #structuralbiology #smfret #fcs

Curious about new routes for labelling often complicated RNAs for single-molecule FRET studies? You'll want to check out Graham et al.'s recently published work in ChemPhysChem (congratulations 🥳) - buff.ly/SkaruHO #rna #rnaresearch #virology #singlemolecule #smfret #nucleicacids

🔎 How does in-solution smFRET reveal the dynamic structure–function links in complex proteins? Watch Prof. @shenk0128.bsky.social's seminar using the EI-FLEX to probe Rag GTPase conformations. Q&A covers labelling, HMMs & why solution-based smFRET matters. youtu.be/2AfskEVyRCI #smfret #biophysics

Two hours to go! Join @shenk0128.bsky.social and @timcraggs.bsky.social as they dive into Rag GTPase regulation, #proteindynamics, and cutting-edge #singlemolecule science. Can’t make it live? Register to get the recording - us06web.zoom.us/meeting/regi... #biophysics #lifescience #biophysics

🚨 Happening this Thursday! @timcraggs.bsky.social and @shenk0128.bsky.social discussing: → cutting-edge single-molecule science → insights into the mechanism and regulation of the Rag GTPase heterodimer Register here: buff.ly/GcdLpHI #seminar #proteins #singlemolecule #biophysics #biochemistry

Professor Robb says: "Our EI-FLEX platform has been central to understanding the molecular details of viral replication and drug action. It’s quickly become a core instrument across many aspects of our virology research." Read her paper here - doi.org/10.1093/nar/... #smFRET #drugdevelopment

⚡ What do you get when you combine a meaningful mission, innovative solutions, and an epic group of people? Something extremely Exciting 😉 We're looking for brilliant people to fill these roles & more > excitinginstruments.com/careers/ #lifesciencejobs #startupjobs #sheffieldjobs #hiring #scaleup

🤔 Who is familiar with the traditional structure–function paradigm that a protein’s atomic structure determines its function? 🧵 1/4

🇨🇭 Meet Roman at #PSDI2025 (poster PO21) to see how our tools reveal drug-induced conformational changes, bringing static structures to life. Then 🇦🇹 join him & Tim at the 8th Austrian Cryo-EM Symposium. DM us to connect! #cryoem #drugdiscovery #structuralbiology

📢 Our Exciting Seminars are back! Join @timcraggs.bsky.social & @shenk0128.bsky.social on Nov 20 for 'Mapping the global conformation of the Rag GTPase heterodimer with single-molecule FRET' > us06web.zoom.us/meeting/regi... #biophysics #lifescienceevent #molecularmedicine #biochemistry #smfret

✨ Watch Dr Erin Cutts use the EI-FLEX and imagine the discoveries you could make yourself! We’re offering labs and core facilities a 2 month EI-FLEX trial at no cost. Run your own samples and see the data for yourself. Apply by Dec 15 → bit.ly/4ojRDhF #singlemolecule #biophysics #lifescience

What happens when fluorescence detection reaches nanosecond precision? Recent work in time-resolved single-molecule FRET from Howard et al. using the EI-FLEX reveals fast, transient conformations and connects photon-level observables with structural and dynamic models - biorxiv.org/content/10.1...

🚀 Exciting news! Submit a short proposal on how you'd use the EI-FLEX in your lab for a chance at a 2-month, no-obligation trial! Plus: see smFRET in action, upcoming seminars and more 👉 www.linkedin.com/pulse/octobe... #biophysics #lifescience #moleculardynamics #singlemolecule

How can our stable, compact, and easy-to-use single-molecule tools bring your static models to life? Check out the poster our Senior Application Scientist shared at last week’s Advances in Structural Analysis of Biomolecules conference👇 #structuralbiology #singlemolecule #molecularbiology

Cut prep time, skip immobilisation, and get real-time molecular insights with Fluorescence Correlation Spectroscopy (FCS). ✓ In-solution, label–mix–measure ✓ Setup in a day ✓ First results in minutes Spend less time prepping, more time discovering. Find out more > bit.ly/47pRqm1 #fcs #kinetics

Average doesn't really exist... so why measure it? Our compact and easy-to-use instrument has been designed to help researchers access dynamic single-molecule insights from their own lab benchtops. Find out more about the EI-FLEX and book a demo bit.ly/3KZK3Ku #singlemolecule #smfret #fcs

🚀 Join our mission to democratise single-molecule analysis! We’re hiring: Scientific Creative Writer Product Manager – Assay Kits Field Application Scientists Apply now 👉 excitinginstruments.com/careers?utm_... #sheffieldjobs #startupjobs #lifescience #hiring

Great chatting dynamic single-molecule data with brilliant scientists at the Crick yesterday! 🇩🇪 Next stop: Advances in Structural Analysis of Biomolecules at Charité Berlin, Oct 23–24. Don’t miss our Senior Application Scientist Mahmoud’s poster - P017! #structuralbiology #chembiochem #chemphyschem

Join Tim Craggs, Paul Wheeler & the single-molecule community at The Francis Crick Institute, London - this Monday! ⚡ Dive into the latest single-molecule research, techniques & discoveries. Free to attend - reserve your spot: www.eventbrite.co.uk/e/single-mol... #biophysics #molecularbiology

Can smFRET deliver reproducible, absolute distance measurements? Yes! Check out Hellenkamp et al.'s (2018) paper to learn more > www.nature.com/articles/s41... #singlemolecule #smfret #biophyics #biochemistry

🚀 Since spinning out in 2021, our journey has been an Exciting one! Thrilled to see our CEO & founder @timcraggs.bsky.social named Entrepreneur of the Month by Insider Magazine. Read Tim’s comment below and the article here 👉 flickread.com/edition/html... #entrepreneur #singlemolecule #sheffield

🚀 Our 'professor in a box', a quick-watch smFRET explainer video, a very exciting Chair appointment and more... see what we've been up to in September in the latest edition of our newsletter - buff.ly/EDA6U5s #structuralbiology #moleculardynamics #singlemolecule #smfret #fcs #deeptech #startups

“Absolutely gorgeous!" That's how Edwin Antony describes the data from our EI-FLEX in his Exciting Seminar, where he discusses how DNA context regulates the myriad roles of RPA. Watch the seminar in full to learn more: youtu.be/r0yowVKdXUI #DNA #singlemolecule #molecularbiology #structuralbiology

🚀 Here comes the next big step in our Exciting journey! Thrilled to announce the appointment of Jonathan Rigby as the Chairman of our Board. Find out more about what it means for Exciting Instruments in the press release below. #innovation #startups #biophysics #Sheffield #pressrelease

🤔 How did Groves et al. use the FLEX to reveal insights about SARS-CoV-2’s RNA polymerase? Find out here > doi.org/10.1093/nar/... Want to know more about the FLEX? Learn more, request a tech spec or book a demo on our website: excitinginstruments.com/ei-flex/?utm... #smfret #RNA #nucleicacids

👋 At the Midlands Biophysics Network meeting today? So are we! Visit our stand to chat about how we're bringing solution-based single-molecule techniques right to your benchtop - no extensive training required. #midlandsbiophysicsnetworkmeeting #biophysics #singlemolecule #smfret #fcs

Thrilled to see long-time #FRET experts moving into single-molecule work with our technology at McMaster University! Plus, our instrument now also supports University at Albany's core facility with #smFRET & #FCS! A very Exciting week! 🙌 #biophysics #singlemolecule #structuralbiology

Tim and Paul are ready and waiting at the Biology and Physics of Prokaryotic Chromosomes conference to show you how in-solution, single-molecule fluorescence spectroscopy can help visualise structural dynamics of prokaryotic protein/DNA interactions. Visit our stand for a chat! #prokaryoticproteins

Missing biomolecular dynamics at picomolar levels? The EI-FLEX makes single-molecule research quick and easy with precision and stability. Watch Dr. Quinn below and book a demo: excitinginstruments.com/contact-us/?... #singlemolecule #structuralbiology #moleculardynamics #smFRET #FCS

Heading to the Austrian Cryo-EM Symposium in November? Let's catch up! We'll be on hand to share how freely diffusing smFRET can complement this already exquisitely detailed technique #cryoEM #smfret #singlemolecule

Discover how single-molecule fluorescence reveals transient DNA–protein interactions, kinetics and conformational changes, and more. Meet @timcraggs.bsky.social & Paul Wheeler at next week’s events - email [email protected] to schedule! #biophysics #smfret #fcs

What is single-molecule FRET? Watch @timcraggs.bsky.social explain how this technique measures nanometer-scale distances and captures single-molecule conformations - youtu.be/BpCsTVJkQyE #structuralbiology #moleculardynamics #discovery #smFRET

X-ray crystallography gives static molecular snapshots with atomic precision. Freely diffusing smFRET adds dynamics, revealing alternative states, transition rates, and validating models. See how Craggs et al. (2019) used it to reveal hidden structures: bit.ly/45Vznoh #smfret #structuralbiology

💡 Measure fleeting protein encounters with ease - no dark rooms, bulky equipment, or extensive training. Our compact instrument delivers fast, publication-ready results from the bench in ambient light. 👉 bit.ly/4683zLQ #smFRET #FCS #biophysics #science

🚀 Hear ALEX and smFRET pioneer Shimon Weiss talk on origins, breakthroughs, and the future 👀 Watch the Exciting Seminar in full > youtu.be/MBI82_QKAnk #smFRET #ALEX #biophysics #structuralbiology #moleculardynamics