Not AI, or maybe it is … - at minimum a new way to explore symptoms 😘

”Plasma measures of p-tau217 can accurately identify individuals in the preclinical stage of Alzheimer disease where interventions are likely to have the most benefit in delaying or stopping disease progression.”

An implant that cures blindness, fantastic news for AMD patients! This could bring bionic sight within reach.

'The Pitt' Has Inspired More Organ Donation and End-of-Life Planning | Michael Schneider for Variety (@Variety) https://variety.com/2025/tv/news/the-pitt-organ-donation-end-of-life-planning-study-1236562186/

A landmark moment for palliative care research! Discover the long journey that led to this breakthrough and why it matters for patients and clinicians. Read the full blog here: https://ow.ly/k31F50XkpUv

Interesting🤔

Robotic surgery outperforms laparoscopic in rectal cancer. Next step: train robots using AI like that in self-driving cars and humanoids. How long before an AI-driven robot beats the surgeon-controlled one?

Excess death in US compared to other high-income countries. This trend can probably only be broken by the Ozempic-pandemic🤔 and maybe some sensible healthcare reforms💡.

Superhuman performance of a large language model on the reasoning tasks of a physician. arxiv.org/abs/2412.10849

Hospitalized patients with dementia are infrequently present in GOC conversations and less likely to have their values and preferences for medical care documented within a GOC note. #geriatrics #palliativecare agsjournals.onlinelibrary.wiley.com/doi/10.1111/...

Human(?) development is about to jump to hyperspace. With small tweaks, this could be applied to everything from scientific research to factory floors and logistics.

“Our study demonstrated associations between obesity, particularly severe obesity, and the incidence of 16 common health outcomes.” 📋 Read the full study results by Z. Yao et al. in NEJM Evidence: eviden.cc/4iIRjGg #MedSky #EndoSky

Heart and Kidney disease are related. Many patients have both, leading to CKM syndrome. http://spr.ly/6048uP0fo As many as 9 in 10 adults with CKD don't know they have it. Kidney disease usually has 0 symptoms, & many people don’t know they have it until it’s very advanced.

Symptom support, unbiased and pure. Taking on the toughest cases: elderly patients. Get diagnoses and suggested investigations. Powered by our own AI (not Big Tech), but we use LLM as a sidekick. Easy, no login, free to use: Oired.com

In the API-CAT trial involving patients with active cancer and venous thromboembolism, extended anticoagulation with reduced-dose apixaban was noninferior to full-dose apixaban for preventing recurrent thromboembolic events. Full trial results and Research Summary: nej.md/41YkRZK #MedSky

In Type 2 Diabetes SLGT2 decreased risk of Alzheimer with 43% and GLP-1 with 33% compared with other DM2 medications. No significant difference between SLGT2 and GLP-1. jamanetwork.com/journals/jam...

Read, learn, think and challenge yourself should be added throughout life.

Zoster vaccine reduced the probability of a new dementia diagnosis by approximately 20% over a seven-year follow-up period.

”On average, each dollar spent on vaccination yields a hefty $54 in returns.” - That is a good investment!

NEJM: Global Effect of Cardiovascular Risk Factors on Lifetime Estimates. With all 5 risk factors (high blood pressure, high cholesterol, diabetes, smoking, and unhealthy body weight) at age 50 lifetime cardiovascular disease risk was 38% in men and 24% in women. www.nejm.org/doi/full/10....

Treating coronary artery disease risk factors early could make it a rare disease. But are we ready to take pills to prevent a disease that might occur 40 years later? Of course, a middle way already exists in clinical practice. However, this Lancet Commission rightly highlights prevention.

About to retire, prepare yourself or risk cognitive decline.

The number of geriatricians is shrinking, just 7,400 in 2022, down from 10,000 in 2000, while the aging population keeps growing. The American Geriatrics Society says we’ll need 30,000 by 2030. The math isn’t adding up!

A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved

#Kindness cannot prevent, slow or cure #Alzheimers. But the presence or absence of kindness fundamentally changes quality of life for people experiencing #dementia and those who are #caregiving. #quote

Gene repair inside the human body is now a reality.

Updated.

This aligns with the clinical picture and not just for dementia: a 75-year-old today is in the same shape as a 65-year-old 30–40 years ago. Possible reasons: Less smoking? Less physical labor? Fewer severe infections (vaccination/antibiotics)? Cholesterol-lowering drugs? Less pollution? …

Digital screen time and myopia risk: Under 1 hour/day relatively safe, but risk increases 21% for each extra hour.. 👓 jamanetwork.com/journals/jam...

A review on Hospital at Home. From my experience: Person-centered care drives satisfaction, familiar surroundings reduce delirium&other risk in seniors AND natural activity at home accelerates rehabilitation - partly by preventing deterioration in the first place.

Innovation & adaptation: Why do we need crises like war to drive significant changes and improvements in healthcare systems? Are we so risk-averse that only extreme pressure compels us to change?

A study in The Lancet Healthy Longevity reports that a personalised home-based interventions - encompassing physical, social and/or dietary activities - reduced emergency hospital admissions by 35% in older adults with mild frailty.

This could probably be used to make any screening much more effective and targeted. By using LLM to select a screening population that are more likely to benefit from the screening.

Nature Medicine: A man with an early-onset Alzheimer’s gene and a brain full of amyloids should have developed dementia by 50, but showed no symptoms at 70! 👀 Interestingly, the typical tau changes were missing, strengthening argument that tau, not amyloid, drives cognitive decline.

An aging population will drive rising healthcare costs. Research should absolutely prioritize this area, not just for health reasons, but also because it makes economic sense.

Oh my Gut! - Bacteria (S. aureofaciens Tü117) in GI tract behind hypertension 👀

Review study: SGLT2 inhibitors & GLP-1 agonists are clearly cardioprotective in DM2. In elderly patients, SGLT2 inhibitors seem most effective - despite a smaller impact on glycemic control.

"Updating STEADI for Primary Care: Recommendations From the American Geriatrics Society Workgroup" (JAGS 2025) - "The proposed additional assessments address the multifactorial nature of falls, ultimately enhancing fall prevention efforts." - agsjournals.onlinelibrary.wiley.com/doi/10.1111/...

Tirzepatide reduced ”worsening of heart failure or cardiovascular death”. But read the result more carefully and you see that death was actually more common in the treatment group than placebo, although the difference is insignificant it would have been good to state more clearly.

Lifetime risk of dementia after age 55 years - 42%.

No clear comorbidities patterns among dementia patients.

What if dementia and frailty are evolutionary features—not flaws? Could they be part of an ancient design, fine-tuned over millennia to help groups, not just individuals, survive? 🧵👇 1/13

Disruptive events such as hip fractures or pneumonia substantially alter the clinical trajectories of people with dementia and are associated with worse outcomes than in people without dementia who experience these events. #geriatrics agsjournals.onlinelibrary.wiley.com/doi/10.1111/...

Our new paper. Why we should be suspicious of claims based on meaningful within-individual change from parallel-group trials of Alzheimer’s treatments. Avoiding causal fraud! alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Advanced care planning (ACP) is one of the most critical aspects of care in geriatrics! Let's explore why ACP matters and how it ensures that older adults receive care aligned with their values. 🧵👇 1/14

Care delivered in corridors and storage rooms is undignified. A modern state can surely do better.

Gene Therapy Prediction: < 5 years - Used in hundreds of diseases where other treatments are often inadequate. You’ll hear “revolutionary” a lot. 5-10 years - Trust is built due to fantastic results and minimal side effects. 10-15 years - Expanded to address common diseases. 2040 - Widespread use.