New paper out now in Science! Check it out! www.science.org/doi/10.1126/...

Our paper showing that acquired resistance to CDK inhibitors can result from simple mutations in the CDK gene is now out - thanks to Chun-Fui Lai, @vcushing.bsky.social @bjgreber.bsky.social with support from @prostatecanceruk.bsky.social @imperialsandc.bsky.social www.embopress.org/doi/full/10....

More than just a bad apple: why we must look closer at the Nathan Gill scandal New evidence connects the Ukrainian politician who paid bribes to Gill - Reform UK’s former leader in Wales - to a campaign to destabilise the US election @carolecadwalla.bsky.social reports

Can specific gene mutations drive CDK7 inhibitor resistance in #ProstateCancer? A brilliant team led by @simak.bsky.social @imperialcollegeldn.bsky.social share exciting new findings in @embojournal.org. Grab a ☕ and read: doi.org/10.1038/s443...

We show a single amino acid change in CDK7 causes acquired resistance to CDK7i in cancer cells. There are implications for patient selection,resistance monitoring and switching treatments. thanks to @vcushing.bsky.social @bjgreber.bsky.social @prostatecanceruk.bsky.social doi.org/10.1038/s443...

This will be a great meeting - and in the sunniest part of the UK!

www.nature.com/articles/s41... A fantastic paper on the dynamics of the estrogen receptor N-terminal domain. A big win for the field and the Yang lab should be commended on their seminal study!

Our publication in Cancer Research (DOI: 10.1158/0008-5472.CAN-24-0013) reveals a route to hormone therapy resistance in #ER-positive breast cancer patients. We show that induction of #VGLL1 drives gene expression programmes that confer resistance to ER degraders.

#science #cancer #breast_cancer #hormone_therapy #transcription

Applications for Endocrine Society's awards programs are open until 1/15, including key early career programs, e.g. Early Career Forum & REGMS research fellowship. These programs are a gateway to grow careers in endocrinology and in ES as a professional home. Apply today! www.endocrine.org/awards

Our publication in Cancer Research (DOI: 10.1158/0008-5472.CAN-24-0013) reveals a route to hormone therapy resistance in #ER-positive breast cancer patients. We show that induction of #VGLL1 drives gene expression programmes that confer resistance to ER degraders.

Super lineup for this conference.

Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.

Yet….. It seems from the data that there is a tendency for better efficacy in CDK4/6i-first. But the p-value is 0.1… what if the n were bigger? The tyranny of the p-value? #oncoSky #oncosky🧪

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

📢 Looking for a #postdoc position in the intersection of #cancer, #chromatin and #epigenetics??? Still a few days left to apply to our lab in wonderful Denmark as part of the new translational cancer hub initiative🇩🇰🧪👇🏻

In other news millions of people in the UK are living in poverty, destitution & using food banks

From these data, we derived the mechanism of CDK7-selectivity of the clinical compound and formulated a hypothesis for a secondary mechanism of selectivity in this compound class. We tested this hypothesis successfully by analysis of the compound CT7030.

Ok first post on Bluesky and it’s a science one… New paper out from the lab! APOBEC genes protect us from viral infection but go rogue in cancer. Here we shed new light on how these important genes are regulated, offering clues as to what goes wrong in cancer. www.embopress.org/doi/full/10....

It’s so important we support @bylinetimes.bsky.social. It’s the newspaper we’ve all been waiting for. Truly independent journalism at its very best subscribe.bylinetimes.com

A number of artists and creators have made their home on Bluesky, and we hear their concerns with other platforms training on their data. We do not use any of your content to train generative AI, and have no intention of doing so.

This was missed due to major live events happening around the same time, but we have released some of our high-resolution (2 Å) and rapid screening #cryoEM maps & models of the human CAK bound to small molecules. Paper still under review - more to follow. www.ebi.ac.uk/emdb/search/...