This book by Kang Wu is all about #tidyplots 🤩 It’s packed with beautiful example plots and their code. Kang really pushes #tidyplots to its limits—and sometimes even beyond 😂 tidyplots-book.pages.dev @wukang.bsky.social #rstats #dataviz #phd

"NK cells can exhibit adaptive features after specific activation, such as clonal expansion and antigen-memory generation, mainly in response to viral infections" onlinelibrary.wiley.com/doi/10.1111/...

“To enrich only for the Mtb-libraries, a myBaits Custom Hybridization Capture Kit (Daicel Arbor Biosciences) was used, including biotinylated RNA probes (baits), with sequences corresponding to the genome of Mycobacterium tuberculosis” www.sciencedirect.com/science/arti...

"CD11clo monocyte-derived cells ... express lower levels of interferon-gamma (IFNγ) signaling proteins, resulting in reduced responses to IFNγ" "heterogeneous IFNγ responsiveness is exploited by Mtb for persistence in vivo" www.nature.com/articles/s41...

"type I IFN-dependent and IFN-independent neutrophil signatures in bronchoalveolar lavage from patients with active TB and TB progressors." www.nature.com/articles/s41...

Received: 2025-07-22 Accepted: 2025-12-11 Retracted: 2026-06-24 "Participants were enrolled at Hunan Cancer Hospital..."

Ross Ihaka and Robert Gentleman became known as `R&R`. "According to the R Project’s website, the R Core Team consists of 19 people". www.auckland.ac.nz/en/news/2026...

Something like: "For me at least, I find trial and error in a state of desperation and frustration to be the best (only?) way to pick up many important new skills." petebankhead.github.io/qupath/scrip...

"As of 2023, more than half of the 50,002 publications that had been retracted around the world involved at least one Chinese research institution — more than five times the number from the United States" www.nature.com/articles/d41...

"R started in the early nineties, when Robert Gentleman and Ross Ihaka created another implementation of S, for which John Chambers would receive the 1998 Software System Award of the Association for Computing Machinery."

"While not all published, we estimate that several thousand cancer patients have been treated with an NK cell-based strategy over the past 2 decades worldwide against a variety of cancers." This should be the legal number. How about the illegal number? www.nature.com/articles/s41...

The Cell one has three antigens. The Nature one has eight/nine antigens. The two have no overlap in antigens.

Two tuberculosis mRNA vaccine candidates. www.nature.com/articles/s41... www.cell.com/cell/fulltex...

"tightening alcohol use guidance in the United States, for both males and females, to no more than 1 drink per day." "a standard drink = 13.6 g of ethanol" So, do not consume any alcoholic beverages if possible.

“exercise-induced signaling factors (‘‘exerkines’’)—including cytokines, metabolites, catecholamines, and microbiota-derived products” www.cell.com/immunity/ful...

"Instead of antibodies that recognize p16INK4a, a tumor-suppressing protein that may also promote aging, these researchers used antibodies that tag the similarly named protein p16-ARC, which helps shape the cell’s molecular skeleton."

"Well-intentioned problem-solving can produce self-reinforcing inefficiencies."

How does the mycobacterial vacuole go from damage that can still be repaired to full rupture? 👀 Our new preprint shows that EsxA and PDIM act sequentially: EsxA initiates repairable lesions, and PDIM helps push them past host repair capacity toward cytosolic escape. doi.org/10.64898/202...

A larger proportion of families invest too much money and time just in (useless) scores. Of course, there are some god-given talented guys (a probability event), even if the education system is bad. Innovation starts in schools — lessons from China www.nature.com/articles/d41...

"MTB Nucleic Acid Test Card (MiniDock MTB, Guangzhou Pluslife Biotech) is a qualitative molecular test designed for detecting M. tuberculosis complex with MiniDock PM001 Ultra, a low-cost, portable, battery-operable isothermal platform." www.nejm.org/doi/full/10....

Every disease/condition should be continuous, not discrete. For a (new) diagnostic approach, the challenge should be to detect as many asymptomatic individuals as possible.😀 www.nature.com/articles/s41...

My thought when I was cycling this morning: since peptideins = peptides + proteins, so 肽白质 = 肽 + 蛋白质 in Chinese？ English dictionary has one more new word (i.e. peptidein)😀

Those linked to slower aging: engaging with arts and culture, exercise, 6-8 hours of sleep each day ... www.nature.com/articles/d41...

"about 25% of a set of 7,264 ncORFs gives rise to detectable peptides in a large-scale analysis of 95,520 proteomics experiments" "‘peptideins’ as microproteins that have indeterminate potential as functional proteins." www.nature.com/articles/s41...

So do the (immuno)therapy or vaccination in the afternoon rather than in the morning? and do have regular/balanced meals, rather than fasting.

“mice over-estimate the importance IFNγ in host resistance to TB due to a species-specific induction of iNOS by IFNγ” www.nature.com/articles/s41...

"While CD8+ T cells primed exclusively by either cDC1 or cDC2 cells showed phenotypic differences, both could mediate anti-tumour responses and memory formation." www.nature.com/articles/s41...

For Chongqing/Sichuan hotpot, you normally need to dip your food in sesame oil (fat) before putting it into your mouth. High-fat diet causes rapid loss of intestinal group 3 innate lymphoid cells through microbiota-driven inflammation and mitochondrial stress: Immunity www.cell.com/immunity/ful...

So perhaps everyone needs to have a regular and balanced diet, even though fasting might be a fashion for someone at some time. Fasting impairs humoral immunological memory by β-hydroxybutyrate-mediated depletion of plasma cells: Immunity www.cell.com/immunity/ful...

18 sites across India 12717 household contacts VPM1002 showed vaccine efficacy of 21.4%, 19.5%, and 50.4% (95% CI: 0.8% to 75.2%) against all TB, PTB, and extrapulmonary TB, respectively. Immuvac showed vaccine efficacy of 33.2% against extrapulmonary TB. www.bmj.com/content/393/...

"AT-108, a replication-deficient adenoviral vector encoding the human PU.1, IRF8, and BATF3 transcription factors (1), enables in vivo cell-fate conversion of cancer cells and other cells in the tumor microenvironment (TME) into induced cDC1-like cells (iDC1s)" www.science.org/doi/10.1126/...

Copy paste into the address bar of your browser for a random generative artwork. No AI involved.

"This (i.e. in vivo CAT T) cut enrollment-to-treatment time to eight hours, compared to several weeks for ex vivo CAR T." www.nature.com/articles/s41...

This is how you can install a specific version of a package 🤓 In these cases 📦 pak.r-lib.org comes in very handy #rstats #dataviz #phd

"Current clinical development pipeline of preventive tuberculosis vaccines" www.thelancet.com/journals/lan...

What we should be doing, but we're not: "Arming the immune system for the next zoonotic coronavirus spillover" A nasal dendritic-cell targeting vaccine that prevents viral transmission vs pan-sarbecovirus clades (i.e. all coronaviruses, irrespective of variants) www.jci.org/articles/vie...

2. Stay in the field long enough and people will find you. You don't need to go viral. You just need to keep showing up and sharing what you know. Consistently. For years.

Pros and cons of NK cells from different sources. link.springer.com/article/10.1...

"HLA-independent T cell (HIT) receptor (26), which substitutes the antigen recognition domain of a T cell receptor (TCR) with that of a CAR, thereby co-opting the downstream signaling afforded by the CD3 complex" www.science.org/doi/10.1126/...

"Organoids, also referred to as ‘mini-organs’, are three-dimensional (3D) in vitro grown structures exhibiting either complete or partial resemblance to in vivo organs in terms of cellular organization, microanatomy and architecture." pmc.ncbi.nlm.nih.gov/articles/PMC...

iCLAP: integrable Co-detection of Low-Abundant Proteins. "enables sensitive and highly multiplexed protein detection within the same FFPE tissue section" www.nature.com/articles/s41...

4i: iterative indirect immunofluorescence imaging. www.science.org/doi/10.1126/...

IMC: imaging mass cytometry. "coupled immunohistochemical and immunocytochemical methods with high-resolution laser ablation to CyTOF mass cytometry." www.nature.com/articles/nme...

t-CyCIF: tissue-based cyclic immunofluorescence. "conventional low-plex fluorescence images are repeatedly collected from the same sample and then assembled into a high-dimensional representation." elifesciences.org/articles/31657

CODEX: CO-Detection by indEXing. Multiplexed DNA-tagged antibody staining. www.cell.com/cell/fulltex...

There are two nonavalent HPV vaccines, one approved by the FDA in the USA (2014), the other one approved by the NMPA of China (2025). www.mdpi.com/2076-393X/14...

"hypoxia correlates with immune cell state and organization within granulomas and might subvert immunity to TB" www.nature.com/articles/s41...

I only knew the transwell assay and the wound healing assay.

"The median age of patients with HAdV infection was 3 years, with infants aged 0-2 years accounting for the majority (41.39 %)." www.sciencedirect.com/science/arti...