Just published: a review on the impact of #gender on #antibiotic use. In the era if #personalized medicine, taking into account gender is anothe piece of the #puzzle of antimicrobial management. www.tandfonline.com/doi/full/10....

Predictors of mortality of Enterococcus faecium bloodstream infections: results from a 5-year retrospective study at Padua University Hospital. One the largest cohort in the literature on the topic. - International Journal of Infectious Diseases www.ijidonline.com/article/S120...

Just published new #breakpoints by #EUCAST. #Bad news: values for #TMP_SMX have been significantly #lowered for key #pathogens. Bad news under an #antimicrobial_stewardhisp perspective since the combination is a cornerstone of #Oral_is_the_new_IV. @escmid.bsky.social #IDSky.

Nice brief overview on how to reconsider treatment targeting #PBPs, going beyond the simple fact that beta-lactams inhibit synthesis peptidoglycan. @sidpharm.bsky.social @contagionlive.bsky.social www.contagionlive.com/view/penicil...

Proud of the acceptance of a comment on a relevant paper on the combination between colistin and meropenem for invasive #CRAB infections.

Just published in @cidjournal.bsky.social a letter on the need to definitely move on in the treatment of #CRAB (#acinetobacter) infection, without further investing energies in assessing regimens (colistin plus meropenem) largely suboptimal. academic.oup.com/cid/article/...

Fantastic #decision_support_system to assess patients coming from abroad for #HCID (high consequences #infectious #diseases). Designed for #UnitedStates #physicians but useful even for specialists of other continents as #Europe. #IDXposts www.cambridge.org/core/journal...

#SARSCoV2 has not disappeared. It has become even more insidious for immunosuppressed #patients, especially the ones with impaired humoral response, ensuing in a #chronic #infection. A letter in #NewMicrobesAndNewInfections takes sticks of the evidence. www.sciencedirect.com/science/arti...

Potentially useful alternative to benzathine penicillin G for early #syphilis: oral cefixime (although with the downside of a 14-day course). Small but interesting #RCT. #IDSky academic.oup.com/jac/advance-...

📺 New from FirstCallID: Non-Resolving Skin & Soft Tissue Infections When cellulitis isn’t improving, it’s easy to reach for broader antibiotics. But there’s a better way. Here is a clear, structured approach: 🧩 DDx 🚩 What to rule out 💊 Next steps 🔗 www.firstcallid.ca #FirstCallID #idsky #MedEd

Novel @idsainfo.bsky.social #guidelines on #urinary_tract_infections for the first time clearly address #complicated forms and revolve around 4 domains: 1) #definitions; 2) #empirical choices (crucial the presence of #sepsis); 3) #switch to oral #antibiotics; 4) #shorter therapies. #IDSky

Finally out the #guidelines by @idsainfo.bsky.social on #urinary_tract_infections, introducing new definitions and providing important nuanced indications for #treatment. #IDSky #MedSky

Just published in #Infection (#OpenAccess) likely the largest (retrospective multicenter) cohort so far comparing #Meropenem_Vaborbactam and #Ceftazidime_Avibactam for #KPC infections (#BSI and #pneumonia) in #ICU #patients. link.springer.com/article/10.1... #Italy #IDSky #PropensityScore

Very informative #Pk_Pd study from @Clinicalpharmacokinetics on #acyclovir dosing for #HSV/#VZV #encephalitis. Standard regimens (10 mg/kg TID) may be inadequate . Alternative strategies: increasing dosing (QID) or extending infusion durations. #IDSky link.springer.com/article/10.1...

The primary cause of the resurgence in #measles cases is failure to vaccinate, not failure of the #vaccine". Landmark #review on measles in @nejm.org, facing #pathogenesis, clinical #picture, #management and #prevention in the era of its #resurgence. #MedSky #IDSky www.nejm.org/doi/full/10....

Finally in volume (on Expert Review of Anti-Infective Therapy) the narrative review on the management of methicillin-resistant Staphylococcus aureus bloodstream infections. Below is the eprint link for free download. www.tandfonline.com/eprint/IE3MK...

Very precious indications from Canadian Society of Internal Medicine for "high-value, low-carbon care" against the backdrop of climate change. Emphasis is put on oral antibiotics instead of intravenous whenever possible. link.springer.com/article/10.1...

#Vitamins are just "a small piece of the puzzle that determines infection susceptibility and severity" so general #supplementation is not a way to treat or prevent #infections. An exception is #Vitamin_A useful against #measles, especially in (malnourished) #children. #MedSky #IDSky

Very informative review from @nature.com (Reviews #Microbiology) on how #vaccination in #pregnancy protects newborns, covering immunological aspects and providing practical recommendations. #IDsky #MedSky www.nature.com/articles/s41...

Tecovirimat is available to treat mpox in the United States and Europe, but evidence for its efficacy and safety from randomized, controlled trials has been lacking. Findings from the PALM007 trial are summarized in a new Quick Take video. nej.md/4js3uHE #MedSky #IDSky

Just published a multi-author #review born from a successful multidisciplinary approach (infectious diseases, microbiology, clinical pharmacology, intensive care) on #MRSA #BSI. Focus on #classification, #diagnosis and #therapy. Link to the paper: www.tandfonline.com/eprint/IE3MK... #IDsky #MedSky

#FUTURE_AI: an international consensus guideline for trustworthy and deployable #AI in #healthcare from @bmj.com in its "Research Methods & Reporting" section. A set of 30 best practices to cover the entire lifecycle of healthcare #AI. #MedSky #IDSky www.bmj.com/content/388/...

#IDSky #MedSky #PharmSky @idsainfo.bsky.social @cidjournal.bsky.social @ofidjournal.bsky.social @sidpharm.bsky.social 🚨 In this #BMJ article we update the clinical practice approach to adult fever of unknown origin #FUO! bmj.com/cgi/content/...

Just published commentary in Critical_Care about the pitfalls underlying the "culture-negative" #sepsis definition, especially when dealing with #antibiotic appropriateness. Novel and fast #microbiology techniques are essential. #IDSky #IDsky ccforum.biomedcentral.com/articles/10....

Worrying prediction according to mathematical modeling of the advent of a pandrug-resistant E. coli: #sepsis death in the #UnitedStates could increase 18- to 46-fold within 5 years. www.nature.com/articles/s43... #IDSky; #idsky

Great results combining two landmark #trials (TB-CHAMP and VQUIN) in a #Bayesian framework to test efficacy of #levofloxacin to prevent #MDR_TB in #children. #MedSky #IDSky evidence.nejm.org/doi/full/10....

Notable article: #ELIMINATE phase 2 #RCT testing a cocktail of six bacteriophages in the setting of uncomplicated #urinary tract #infection. #Phage therapy is the future to counter #AMR, at least as complementary strategy to traditional antibiotics. #IDSky #MedSky www.thelancet.com/journals/lan...

#Infections of the #eye are frequent (although of minor severity in most cases), but are often a neglected topic in the training path of an #ID physician. Usually well-written #review from @cidjournal.bsky.social takes stock of the subject. academic.oup.com/cid/article/...

A great international effort to delve into many aspects of #prevention and #management of #infection, issued in the #AMR #Awareness week. Glad to have given a contribution about #Clostridioides_difficile. #IDSky infectionsinsurgery.org/global-digit...