New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵

Proud of Louisa Iselin. Not the easiest PhD, covid, two supervisors (shabazlab.bsky.social) moving labs, but she pushed through and delivered a really solid piece of work on how interferon reshapes RNA-protein interactions post-translationally www.cell.com/cell-reports...

Excited to share that this work is now published in its final form! link.springer.com/article/10.1...

🚨🚨 News from the @castello-lab.bsky.social and @shabazlab.bsky.social. Our work, led by Louisa Iselin, reveals pervasive changes in the RNA-bound proteome induced by interferon. #RNA, #immunity, #interferon, #host-virus www.biorxiv.org/content/10.1...

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

Amazing work of our dear friends @ilandavis.bsky.social and @jeffylee.bsky.social characterising the interlinked roles of two key RBPs in drosophila brain development, congratulations 🍾🥂🎉🎉🎉 www.science.org/doi/10.1126/...

Jeff Lee et al paper from my lab is out now www.science.org/doi/10.1126/... I am very grateful to Jeff, Nile's and Tamsin for all the hard work on this tour de force paper. Jeff deserves more credit than me for masterminding it and the outstanding data analysis: 2 RBPs over 3 developmental times.

Following our recent publication, here’s a striking collage of developing fly brain! 🧠✨ Highlighting the dynamic expression of RNA-binding proteins Imp (green) and Syp (magenta) www.science.org/doi/10.1126/...

🧠🔬How do RNA-binding proteins shape brain development? Our latest study reveals how Imp & Syp form combinatorial networks to regulate Drosophila neurogenesis. Excited to share this work in #ScienceAdvances! 📜 Read more: www.science.org/doi/10.1126/... #ilandavislab #RNA #neurogenesis