Why do schizophrenia GWAS signals look so flat across the genome? In our recent preprint, we explored why psychiatric disorders — and, more broadly, brain-related traits involving the central nervous system — appear to have unusual genetic architectures. 🧵1/n

I am sorry, I would like to see a rematch please. I trust this article more than the narrator. 😭😭😭 #2026MMM

I got full score last battle! Ready for Library Legends arena #2026MMM

Not a favourable start ...

I'm excited to present this new model to detect positive selection on regulatory sequences, which has been 3 years in the making! Thanks to Alexandre Laverré and @Phylogenetrips for their amazing work on this project. 😃 https://doi.org/10.1101/2025.11.26.690685 #bioinformatics #MolecularEvolution

We posted a preprint on Zenodo: “The important role of community engagement in genetic research: Lessons from the study of Bornean contemporary hunter–gatherers” (zenodo.org/records/1875...). We present a practical, field-tested approach to doing genomics with Indigenous communities. 1/

demografr: A toolkit for simulation-based inference in population genetics https://www.biorxiv.org/content/10.64898/2025.12.18.694482v1

Gene expression changes aren’t just about mean shifts — variability shifts matter too, especially for aging. We're thrilled to introduce QRscore, a flexible non-parametric framework for detecting shifts in mean and variance across conditions. doi.org/10.1016/j.cr...

SimHumanity: Using SLiM 5.0 to run whole-genome simulations of human evolution https://www.biorxiv.org/content/10.1101/2025.09.01.673541v1

Invasion preferences suggest a possible role for Plasmodium falciparum parasites in the expansion of Duffy negativity in West and Central Africa https://www.biorxiv.org/content/10.1101/2025.07.09.663497v1

My first PhD paper on the importance of populations in small islands for the survival of megafaunas is out! In sum, the ~100 whole genome sequences of anoa & babirusa, forest cover & climate model of their habitat, all agree that small-island pops are dope. #consgen www.pnas.org/doi/10.1073/...

When should adaptation arise from a polygenic response versus few large effect changes? https://www.biorxiv.org/content/10.1101/2025.05.15.654234v1

A hot take. #ethics #DireWolf #CRISPR but in both cases, "science" won.

Thrilled with the release of this Terra Australis volume about the West New Guinea, exploring the rich human past of this fascinating region. Honored to have contributed chapters to this volume.

Do mutations that drive evolution improve many traits or few? Does this change over the course of evolution? Excited to share our work in PLOS Biology exploring these questions in the first 2 adaptive steps w/ Yuping Li, @gsherloc.bsky.social, @petrovadmitri.bsky.social 🧵 doi.org/10.1371/jour...

Excited to share a new preprint with @jnovembre.bsky.social ! We use a combination of population genetic theory, simulation, and data analysis to ask: how does study design in genetic studies (including biobanks) impact the discovery of rare, deleterious variants?

Just your regular reminder how awesome this review on inbreeding depression is. www.nature.com/articles/nrg...

🚨 This will become a curated list of awesome tools for complex trait genetics, **add yours**! it may become a review in which case those who contribute are invited as co-authors.

It's a common knowledge that EPAS1 is enriched, and pos selected, in Himalayan highlanders. But i keep being astonished by the peaked frequency in the Himalayan highlander population given relatively recent split with the Han. Do we know the selection coefficient of these EPAS1 alleles in the pop?

Oh the landscape block will surely come in handy 👍

Optimist: The cup is half full. Pessimist: The cup is half empty. Population geneticist teaching drift: Sample with replacement the atoms of water in this cup until the next cup is full and assume the total number of atoms stays constant.

Noob here. Migrating from Black to Blue. 1st intro post with 0 follower Hello world! My name is Pai. A Wellcome Int'l Training Fellow at MR Institute Indonesia and an Honorary Research Assoc at McDonald Inst for Archaeological Research, Uni Cambridge. Looking forward to a more peaceful life here.