This is interesting, but likely only the tip of the iceberg because normally inhibiting complex1 is NOT a good thing: it causes electron leak and massive oxidative damage. And it also does not normally feedback on glucose levels. www.science.org/doi/10.1126/...

The link between mitochondrial bioenergetics and brain aging reported in Science. A beautiful study by our neighbours, Huan Ma lab demonstrates that restoring excitation-transcription coupling in mitochondria can improve memory function. This has a potential to reverse age-related cognitive decline.

Out today @NatureAging! Life stress can accelerate aging and shorten lifespan, but how remains unclear. We identify that hippocampal/cortical neurons acquire features of p16-dependent #senescence and DNA damage in mice exposed to chronic social stress. Lyons et al. doi.org/10.1038/s435...

Elucidating the spatiotemporal dynamics of glucose metabolism with genetically encoded fluorescent biosensors doi.org/10.1016/j.cr...

Another starter pack of fine fine folks - New PIs! We're all figuring it out together! Please do (self-)nominate go.bsky.app/KJXNgfZ

Our latest preprint out on bioRxiv...we show that glymphatic function influences synuclein propagation in the brain 🧠

Science Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states www.science.org/doi/10.1126/...

Nedergaard lab- impaired increase of infra-slow (30s) norepinepherine-oscillations in APP/PS1 mice after sleep deprivation. Suggests Amyloid-β (or γ-secretase) may impair it's own glymphatic clearance... www.cell.com/cell-reports...

Super useful tool to import list of people you were following on Twitter to 🦋

Woo hoo! 1K new followers, welcome to 💙🦋! For science-minded folks, there are some very cool tricks 🚀… If you use any of these emojis: 👩‍🔬|👩🏻‍🔬|👩🏼‍🔬|👩🏽‍🔬|👩🏾‍🔬|👩🏿‍🔬 your post will index on a Women in STEM feed If you use 🧪 a Science feed If you use 🧠 a Neuroscience feed Go get it 🚀🧪🧠👩‍🔬💙🎊

This is a fantastic analysis from student journalists at Penn who have done a better job covering various interests, and the stakes, on our campus than many major media outlets have done all year…

We often assume textbook depictions can capture all of the diversity seen in living things--spoiler--they don't. Here's a remarkable example: Mitochondria in neuronal axons lack DNA and don't generate ATP!!! 🧪 1/2 www.biorxiv.org/content/10.1...