Lingchong You
@lingchongyou.bsky.social
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Lingchong You
Bacterial Genomics
4 months ago
Scaling laws of bacterial and archaeal plasmids
www.nature.com/articles/s41...
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Scaling laws of bacterial and archaeal plasmids - Nature Communications
The capacity of a plasmid to express genes is constrained by parameters such as its length and copy number. Here, Maddamsetti et al. present a computational method that enables rapid and accurate dete...
https://www.nature.com/articles/s41467-025-61205-2
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Lingchong You
Jerónimo Rodríguez-Beltrán
4 months ago
🚨🚨New paper out in
@natcomms.nature.com
!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉
www.nature.com/articles/s41...
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Universal rules govern plasmid copy number - Nature Communications
Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...
https://www.nature.com/articles/s41467-025-61202-5
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1/ What's the worst enemy of a plasmid? Another plasmid! Our new study demonstrates synthetic plasmids engineered as "Trojan horses" to eliminate plasmids encoding antibiotic resistance.
@dukeubme.bsky.social
www.science.org/doi/10.1126/...
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A predatory gene drive for targeted control of self-transmissible plasmids
A biological “denial-of-spread” (DoS) strategy leverages retrotransfer to eliminate target plasmids in microbial communities.
https://www.science.org/doi/10.1126/sciadv.ads4735
7 months ago
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1/n. Excited to share our newest paper just published in
@natchemeng.bsky.social
, exploring how biomolecular condensates can be used to control metabolic pathways in cells.
www.nature.com/articles/s44...
add a skeleton here at some point
8 months ago
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Lingchong You
Marine C. Cambon
8 months ago
Thank you
@evolvedbiofilm.bsky.social
for such a great organisation and everyone for the fantastic discussions. I even managed to visit Amsterdam Microbe Museum before catching my train! Looking forward to hosting you,
@sofiaifgomes.bsky.social
and Xinming in Birmingham !
add a skeleton here at some point
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1/n. Excited to share our latest work published in
@naturecomms.bsky.social
, exploring how antibiotics reshape microbial communities. We reveal two critical factors driving the complex restructuring outcomes observed after antibiotic exposure.
@dukeubme.bsky.social
doi.org/10.1038/s414...
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Antibiotic-mediated microbial community restructuring is dictated by variability in antibiotic-induced lysis rates and population interactions - Nature Communications
Antibiotic treatment usually selects for fast-growing bacterial cells, but that is not always the case. Here, Kim et al. show that antibiotic-induced changes in bacterial communities depend on variabi...
https://doi.org/10.1038/s41467-025-57508-z
8 months ago
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Lingchong You
Michael Brockhurst
10 months ago
Out now:
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
Fun collaboration with
@biotechdixon.bsky.social
and great work by PhD Alejandro! I guess we really do biotech now?!
add a skeleton here at some point
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Lingchong You
Gene Chong
10 months ago
A new paper from Lingchong You's group develops a cool amplification circuit that expands the dynamic range of plasmid transfer
#ChemBio
#synbio
#microsky
www.nature.com/articles/s41...
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Population-level amplification of gene regulation by programmable gene transfer - Nature Chemical Biology
Gene regulation in engineered microbial populations is often tuned at individual cell levels. Now, a population-wide amplification system has been devised that expands the dynamic range of plasmid tra...
https://www.nature.com/articles/s41589-024-01817-9
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1/ Hello BlueSky world -- my first post is about a new study from the lab, just published in
@nchembio.bsky.social
. We demonstrate how population-level gene regulation can be dynamically controlled and amplified using programmable gene transfer. Link to paper:
doi.org/10.1038/s415...
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Population-level amplification of gene regulation by programmable gene transfer - Nature Chemical Biology
Gene regulation in engineered microbial populations is often tuned at individual cell levels. Now, a population-wide amplification system has been devised that expands the dynamic range of plasmid tra...
https://doi.org/10.1038/s41589-024-01817-9
10 months ago
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