We’ll have a shorter version of our Spatial Transcriptomics workshop at ABACBS as part of the BiocAisa stream. See you in Nov in Adelaide 😃 blackochrelabs.au/abacbs2025_w...

I find it disrespectful when people, such as Pauline Hanson, wrap themselves in our flag and treat it as a cheap theatrical prop to push their political agenda. Anne Maki, Alphington @theage letters

Habits taught physicists to look for elegant laws in biology. But biology’s only rule is: whatever works. Whatever that works, regardless how inelegant, will be embedded in organisms via evolution. This reminds me of the recent Themis to Workday mayhem at unimelb. Don’t change what already works!

A very successful workshop on spatial transcriptomics! Great fun working with @bhuvad.bsky.social & Melody Jin. The audience were most engaged 🥰 Out materials covers QC, normalisation, cell states annotation, niche identification and differential genes in ST data: bhuvad.github.io/CosMxSpatial...

Very very excited to have mixOmics shortlisted as a finalist! 🥳 A great recognition of our contribution to research software in #Rstats @mig-unimelb.bsky.social

Amazing opportunity to work at the cutting edge of statistics and omics with us at Melbourne Integrative Genomics @mig-unimelb.bsky.social, University of Melbourne. Closes: 29th August. Contact: Prof Kim-Anh Le Cao (director of MIG) Junior to mid career level Apply here: tinyurl.com/yu97nrws

Great to be part of the ambitious project to marry metabolism and lineage tracing in cancer 😃

Come and join national experts and local colleagues learning spatial transcriptomics data analysis 😃 I expect a lot of inspiring conversations and mutual learning.

First time giving talk in a chapel(-like venue)

Great to have talked about PhiSpace at WEHI. I think we have the coolest team member photos.

PhiSpace has 7 case vignettes now, covering bulk RNA-seq, single-cell multiomics and spatial RNA-seq. Particularly surprised by the performance of PhiSpace when applied to quantify T cell state changes caused by genetic perturbations. jiadongm.github.io/PhiSpace/art...

A new test for LLM? 😂 Seems that the newest Claude 4.0 has no clue about violin finguring. It says the openning bar of violin part here is played using 1st position, but it should be 3rd. I tried a few pieces. Seems that Claude has no difficulty understanding other aspects but finguring

It continues….. www.theguardian.com/us-news/2025...

MIG has an official linkedin account now! It's time to follow it (we need just five more followers before start posting exciting content 😂) www.linkedin.com/company/melb...

When Menzies founded the liberal party a big part of their support actually came from women and first home buyers. A Stark contrast.

Program for Cold Spring Harbour Symposia on Quantitative Biology 1947: nucleic acids and nucleoproteins. Two talks a day!

In Fisher’s textbook, experimental design is an integral part of stats. For example, he said correlation is often for observations which we cannot control (eg human height). When there are controlled experiments, correlation is seldom needed: we need regression and hypothesis testing instead

With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive

Australia completely lacks a dedicated training program for clinician scientists. With the vision and support of VMIAL @petermaccc.bsky.social is extremely proud to announce the first clinician-scientist fellowship. If you meet the eligibility criteria PLEASE APPLY! www.nature.com/naturecareer...

Fisher (1936): each generation has found in Mendel’s work what they expected to find, ignored what did not conform to their theory - the first generation (Mendel’s contemporaries) thought it’s just another paper on hybridisation; the second thought it’s incompatible with continuous evolution.

Join the conversation this FRIDAY for Cellular Conversations with @jovmaksimovic.bsky.social , "More biology without (that much) extra effort – using custom probes with 10x Flex to detect cancer fusion transcripts." www.mscience.com.au/event/cellular-conversations-with-dr-jovana-maksimovic/

Seems that geneticists realised very early on (soon after the ‘rediscovery’ of Mendel in 1900) that Mendel’s data collection violated some fundamental principles of statistical experimental design. This led to Fisher’s famous criticism of Mendel’s results as ‘too good to be true’.

Sen. Ossoff: Who out there in the American public is sitting at home demanding that we shut down cancer research and Alzheimer's research?

Exam papers of UniMelb in 1891, not a single question in biology exams was about Darwinism. This reflects a period which Julian Huxley referred to a ‘the eclipse of Darwinism’, ie late 19th early 20th century when Darwinism was seriously challenged and went into oblivion.

First saw Cajal's drawings in Mukherjee's recent book The Song of the Cell, and was immediately amazed by his artistic talent (and patience!) in drawing neurons

in some hospitals tube feed is almost default for head and neck cancer patients experiencing chemo. Another common cause of swallowing difficulty is mucositis, an inflammation and ulceration of the mucous membrane

We built a comprehensive cell atlas of human neutrophils across all maturation stages. Compared to single-neutrophil RNA-seq datasets, our bulk atlas is multiomic and has more refined and reliable cell state labels. PhiSpace was used to query external data. www.researchsquare.com/article/rs-6...

Could this breakthrough research lead to the first treatment for #longCOVID? A world-first milestone made possible through the advanced technologies of the National Drug Discovery Centre. Find out more: www.wehi.edu.au/news/tacklin...

Quite amazing

We identify evidence of off-target probe binding in the 10x Genomics #Xenium v1 Human Breast Gene Expression Panel, compromising the accuracy of resulting #singlecell #spatialtranscriptomics profiles See our preprint for more details: www.biorxiv.org/content/10.1... #AcademicSky 🧵👇 1/n

Discovery of DNA as the material basis of gene is a synthesis of molecular biology and information theory/cybernetics: many biologits couldn't imagine how a 'boring' molecule like DNA can be the basis of heredity. The paradigm shift relies partially on the popularity of 'information' and 'code'.

NNet can discover of fine-grained gene regulatory networks (GRNs) in scRNA-seq data, eg GRNs of a transitional cell state. A natural complement to PhiSpace! We can use PhiSpace for cell state discovery and then use NNet to uncover gene regulation in cell states of interest 🤔😃

📢 MIG Seminar: Models and Truth in Phylogenomics 🗓️ Fri, Apr 11 | ⏰ 12 - 1 pm AEST 📍 Auditorium (G004), Peter Doherty Institute (248) 🎙️ Prof. Rob Lanfear, Australian National University 🧍‍♂️ In-person only #Phylogenomics #EvolutionaryBiology #ScienceTalk #MIGSeminar #ANU #DohertyInstitute

I just signed the Australians for AI Safety open letter calling for responsible AI governance in Australia. Join me in supporting this important cause: www.australiansforaisafety.com.au/letters/fede...

Building website for PhiSpace is fun, because I can write more casually and insert random thoughts about statsitical methods, biology and even history of science 😆 jiadongm.github.io/PhiSpace/ind... Spoiler alert: history of science is in the Stereo-seq case study.

Are you a bioinformatician looking for an exciting opportunity in Melbourne? Is cancer genomics your passion? Apply now! www.nature.com/naturecareer...

We are looking for a talented postdoctoral bioinformatician @thedawsonlab.bsky.social to work with us on single cell multiomics incorporating lineage tracing and spatial technologies- we specifically want someone curious, fearless with a licence to innovate!! Come join us!!

New spatial method, Perturb-FISH, combines imaging-based spatial transcriptomic measurements with CRISPR screening to reveal effects within and between cells. #Science

🚀 Join MIG! We're hiring an Office Coordinator! 📍 12-month fixed-term (full-time or part-time) 🎓 Admin experience preferred 📅 Deadline: Mar. 20 Apply now! 🔗 jobs.unimelb.edu.au/en/job/91954... Know someone great? Tag or share! #Hiring #JobOpportunity #UniversityOfMelbourne #Genomics #AdminJobs

📢 MIG Seminar🚨 Join Assoc. Prof. Xin He (University of Chicago) for a talk on computational methods for human genetic variation & single-cell CRISPR screening! 📅 Friday, Mar. 14 📍 Ian Potter Auditorium, KMB (144) 💻 Zoom available Don't miss it! #MIGSeminar #Genetics #CRISPR #Bioinformatics

🚀 Upcoming MIG Workshop 🧬 Join Xiaochen Zhang @sheldonzhang.bsky.social for an intro to scRNA-seq in R! 🎓📊 📅 Tues 4 Mar, 9:30 AM - 12:30 PM 📍 B Hive (Room 121), Bldg 184 💰 $25 (Refunded upon attendance) Limited spots! 🔗 events.unimelb.edu.au/MIG/event/44146 #scRNAseq #Bioinformatics #RStats

📣 Registrations and Abstract submissions are now open for Cancer Bioinformatics Australia 2025! Abstracts, due 11th April: cancerbioinformatics.au/abstracts Registration: cancerbioinformatics.au/register Further info: cancerbioinformatics.au See flyer for our amazing invited speakers!

🚨 We're hiring! 🚨 The School of Mathematics & Statistics, UniMelb seeks a scientist in Machine Learning in Omics to lead research in statistical methods for omics. 📍 MIG | 📅 By Apr 11 🔗 jobs.unimelb.edu.au/en/job/91945... #MachineLearning #Omics #DataScience #HigherEd #Mathematics #Statistics

My MIG seminar on PhiSpace ST is available on mixOmics website now 😃 As part of the effort towards mixOmics 2.0, PhiSpace and PhiSpace ST focus on dicovering complex cell states in single-cell and spatial omics data. mixomics.org/2025/02/webi...

New 📃! @sankaranlab.bsky.social collaborated with our lab with Saritha Kodikara to expand scDesign3 @jsb-ucla.bsky.social for realistic microbiome data simulation. We tested in 3 workshops for power analysis, benchmarking & omics integration! 🔗 doi.org/10.1093/bib/... #Microbiome

I'll be presenting this work this Friday (14 Feb), all are welcome 😃 See below for event details. Our colleague Ruqian will also present her spatial work on lung fibrosis: events.unimelb.edu.au/MIG/event/44...